A5039388027- Sinusitis and nasal conditions
- Obstructive Sleep Apnea Research
- Head and Neck Surgical Oncology
- Hearing, Cochlea, Tinnitus, Genetics
- Allergic Rhinitis and Sensitization
- Viral-associated cancers and disorders
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Vestibular and auditory disorders
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Voice and Speech Disorders
- Connexins and lens biology
- Otitis Media and Relapsing Polychondritis
- Otolaryngology and Infectious Diseases
- Hearing Loss and Rehabilitation
- Dysphagia Assessment and Management
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Ear Surgery and Otitis Media
- SARS-CoV-2 and COVID-19 Research
- Congenital Ear and Nasal Anomalies
National Taiwan University Hospital
2016-2025
National Taiwan University
2012-2025
National Yang Ming Chiao Tung University
2018-2024
National Cheng Kung University
2023
Taipei Hospital
2002
Hôpital Lariboisière
1992-1998
Université Paris Cité
1992-1997
Abstract Purpose. This study reviews our experience with deep neck infections and tries to identify the predisposing factors of life‐threatening complications. Methods. A retrospective review was conducted patients who were diagnosed as having in Department Otolaryngology at National Taiwan University Hospital from 1997 2002. Their demographics etiology, associated systemic diseases, bacteriology, radiology, treatment, duration hospitalization, complications, outcomes reviewed. The...
Abstract The coronavirus SARS-CoV-2 is the causative agent of ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism one key to understanding pathogenesis SARS-CoV-2. We investigate expression subcellular localization receptor, angiotensin-converting enzyme 2 (ACE2), within upper (nasal) lower (pulmonary) tracts human donors using a diverse panel banked tissues. Here, we report our discovery that ACE2 receptor protein robustly localizes motile cilia airway...
Conclusions. Broad-spectrum antibiotics are advocated for treating deep neck infection. Anaerobic coverage is necessary, especially in odontogenic cases. The presence of diabetes, infection the parotid space and an obvious source can aid determining causative organisms. Objectives: This study aimed to analyze bacteriology infections identify factors that influenced pathogens.Materials methods. records 212 patients who were diagnosed as having at National Taiwan University Hospital between...
In patients with malignant external otitis (MEO), mortality was not related to age, sex, degree of glucose tolerance, duration diabetes mellitus (DM), microorganism, comorbid disease, or involvement a single cranial nerve. Severe complications such as skull base osteomyelitis, intracranial extension, and multiple nerves were correlated mortality.To analyze the factors that affect survival MEO in today's era advanced antibiotics.Patients diagnosis from 1993 2005 collected.A total 26 mean age...
The purpose of the study is to elucidate mutation spectrum SLC26A4 among patients with enlarged vestibular aqueduct and/or Mondini dysplasia in Taiwan and explore origin most common mutation, IVS7-2A>G. correlation between genotypes phenotypes also investigated, special emphasis placed on comparison hearing levels.A 3-year prospective clinical genetic at a tertiary care university hospital.Mutations were screened 38 families that fulfilled criteria enrollment, single nucleotide polymorphisms...
Recessive mutations in the SLC26A4 gene are a common cause of hereditary hearing impairment worldwide. Previous studies have demonstrated that different may pathogenetic mechanisms. In present study, we established knock-in mouse model (i.e., Slc26a4(tm1Dontuh/tm1Dontuh) mice) homozygous for c.919-2A>G mutation, which is mutation East Asians. Mice were then subjected to audiologic assessment, battery vestibular evaluations, and inner ear morphological studies. All mice revealed profound...
We investigated the expression and subcellular localization of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within upper (nasal) lower (pulmonary) respiratory tracts healthy human donors. detected ACE2 protein cilia organelle ciliated airway epithelial cells, which likely represents initial or early site viral entry during transmission. further determined whether in cells was influenced by patient demographics, clinical characteristics, co-morbidities, medication use, found...
This study examined 11,333 rigid endoscopy procedures performed in the Department of Otolaryngology, National Taiwan University Hospital, during a 27‐year period from 1970 to 1996. Among these cases, 3217 were remove foreign bodies airway (459 14.3%) and esophagus (2758 85.7%). Retrospective analysis data revealed that peanuts (217 cases) animal bones (1184 most frequent encountered esophagus, respectively. The successful rate removal was 99.9% (3213/3217). complication only 0.2% (8/3217),...
The endoscopic endonasal prelacrimal recess approach to the maxillary sinus provides wide access walls and recesses of sinus, its use has been reported in many skull base diseases. objective this study was determine indication feasibility surgery using unilateral diseases.We reviewed 192 cases diseases; over 2 years, 15 underwent via approach. Data regarding preoperative computed tomography scans, operative findings, postoperative pathological diagnoses, complications, disease recurrences...
Understanding viral tropism is an essential step toward reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, decreasing mortality from disease 2019 (COVID-19) and limiting opportunities for mutant strains to arise. Currently, little known about the extent which distinct tissue sites in human head neck region proximal tract selectively permit SARS-CoV-2 infection replication. In this translational study, we discover key variabilities expression of...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition of the and paranasal tissues, characterized by presence bilateral polyps. An expert panel specialists from Asian-Pacific region Russia was convened to develop regional guidance on management CRSwNP through consensus approach. The present article presents chief observations recommendations this provide for clinicians in these areas. Etiology pathogenetic mechanisms are heterogeneous complex. In many...
Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high recurrence rate following endoscopic sinus surgery (ESS). The role of adjunctive biologic therapy remains to be fully elucidated. This study aims assess the efficacy dupilumab in conjunction ESS for patients CRSwNP. We conducted retrospective cohort type 2 CRSwNP who underwent ESS. compared those received postoperative standard care. Changes Lund-Kennedy score (LKES) and polyp (NPS) were recorded, linear mixed models (LMMs)...
ABSTRACT Our previous findings demonstrated that naïve B cells elicit suppressive CD4 + regulatory T (Treg) cells, named as Treg‐of‐B cells. However, the capability of antigen‐specific in process remains unclear. Using ovalbumin (OVA) a model antigen, present study showed from OVA‐immunised mice decreased ability. Instead, OVA‐activated OVA‐specific (OB1) induced effector‐like T‐of‐OB1 without function. Phenotypically, reduced production interferon (IFN)‐γ, interleukin (IL)‐17 and IL‐2...