A5100693400- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Data-Driven Disease Surveillance
- Genomic variations and chromosomal abnormalities
- Spectroscopy and Chemometric Analyses
- RNA modifications and cancer
- Protein Interaction Studies and Fluorescence Analysis
- Chronic Kidney Disease and Diabetes
- Animal Disease Management and Epidemiology
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Viral Infections and Immunology Research
- Transgenic Plants and Applications
- Plant tissue culture and regeneration
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Molecular Biology Techniques and Applications
- Zoonotic diseases and public health
- Congenital Anomalies and Fetal Surgery
- Renal Diseases and Glomerulopathies
Tianjin Medical University General Hospital
2012-2025
Shenyang Pharmaceutical University
2025
Beijing Shijitan Hospital
2025
Capital Medical University
2025
Central South University
2014-2024
Second Xiangya Hospital of Central South University
2019-2024
Weifang Medical University
2024
Chongqing Medical University
2022
State Council of the People's Republic of China
2022
Changsha Medical University
2022
The Hand-Foot-Mouth Disease (HFMD) is the most common infectious disease in China, its total incidence being around 500,000 ~1,000,000 cases per year. composite space-time variation result of underlining attribute mechanisms that could provide clues about physiologic and demographic determinants transmission also guide appropriate allocation medical resources to control disease. HFMD were aggregated into 1456 counties during a period 11 months. Suspected climate attributes recorded monthly...
Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN). However, the role and regulation proximal tubular DsbA-L for tubulointerstitial fibrosis (TIF) remains unclear. In current study, we found a tubules-specific knockout mouse (PT-DsbA-L-KO) attenuated UUO-induced TIF, cell apoptosis inflammation. Mechanistically, interacted with Hsp90 mitochondria BUMPT cells which activated...
Abstract Objectives To reveal the role of circular RNA (circRNA) DOCK1 (circDOCK1) as a potential biomarker and therapeutic target its competing endogenous mechanism in bladder carcinoma (BC). Methods The next‐generation sequencing (NGS) technology was introduced to screen circRNA expression profiles BC using microarray. qPCR Western blots assay were employed measure gene different groups. Cell counting kit‐8, EdU transwell assays applied detect cell viability, proliferation migration...
The molecular mechanism underlying the transition of acute kidney injury (AKI) to chronic disease (CKD) induced by vancomycin (VAN) remains largely unknown.
In this paper, we discuss the use of a procedure based on polymerase chain reaction (PCR) and surface enhanced Raman spectroscopy (SERS) (PCR-SERS) to detect DNA mutations.Methods: This method was implemented by first amplifying DNA-containing target mutations, then annealing probes, finally applying SERS detection.The obtained spectra were from mixture fluorescence tags labeled complementary sequences mutant DNA.Then, multiple decomposed component tag linear regression (MLR).Results: The...
The prediction of mortality for septic acute kidney injury (AKI) has been assessed by a number potential biomarkers, including long noncoding RNAs (lncRNAs). However, the validation lncRNAs as particularly early stages AKI, is still warranted. Our results indicate that lncRNA TCONS_00016233 upregulated in plasma sepsis-associated non-AKI and AKI patients, but higher cutoff threshold (9.5 × 105, copy number) provided sensitivity 71.9% specificity 89.6% detection AKI. was highly correlated...
The pathogenesis of acute kidney injury (AKI) is still not fully understood, and effective interventions are lacking. Here, we explored whether methyltransferase 3 (METTL3) was involved in the progression AKI via regulation cell death. We reported that PT(proximal tubule)-METTL3-knockout (KO) noticeably suppressed ischemic-induced inhibition renal apoptosis. Furthermore, also found expression mmu-long non-coding RNA (lncRNA) 121686 upregulated antimycin-treated Boston University mouse...
Journal Article Upper Bounds on L-Functions at the Edge of Critical Strip Get access Xiannan Li Department Mathematics, Stanford University, Stanford, CA 94305, USA Correspondence to be sent to: xli@math.stanford.edu Search for other works by this author on: Oxford Academic Google Scholar International Mathematics Research Notices, Volume 2010, Issue 4, Pages 727–755, https://doi.org/10.1093/imrn/rnp148 Published: 03 October 2009 history Received: 02 February Revision received: 19 July...
In this paper, we investigated the feasibility of using surface enhanced Raman spectroscopy (SERS) blood serum to discriminate liver cancer and cirrhosis patients from normal people. Serum taken 44 healthy people, 45 patients, 42 post-treatment was measured. SERS peaks these groups were compared assignments biomedical meanings analyzed explained. addition, support vector machine (SVM), partial least square-discriminant analysis (PLS-DA) artificial neural networks (ANN) used on obtained...
Cisplatin (CDDP)-based chemotherapy is a standard strategy for the clinical treatment of patients with bladder cancer (BC). However, anti-tumor efficacy cisplatin affected by multiple chemoresistance complex molecular mechanisms. Recent evidence highlights crucial regulatory roles metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in progression cancers and development drug resistance. underlying mechanisms MALAT1 resistance BC cells remain largely unclear. In this study, we...
Lymph node metastasis in patients with urinary bladder cancer (UBC) is always associated poor prognosis and the determinant for tumor staging development of treatment regimens; however, its underlying mechanisms remain to be studied. Immunohistochemical staining sections from 62 UBC was performed using CCR7, D2-40 CD34 antibodies. We showed that increased CCR7 expression significantly positive lymph status (P=0.008), pT3-T4 stage (P=0.015), grade (P=0.010) worse overall survival (OS,...
DNA methylation plays a pivotal role in the progression of renal fibrosis. Methyl-CpG-binding domain protein 2 (MBD2), reader methylation, is involved development acute kidney injury (AKI) caused by vancomycin. However, and mechanism action MBD2 remain unclear. In this study, mediated extracellular matrix (ECM) production induced TGF-β1 Boston University mouse proximal tubule (BUMPT) cells，and upregulated expression EGR1 to promote ECM murine embryonic NIH 3T3 fibroblasts. ChIP analysis...
Recent studies have shown that autophagy exhibits a renoprotective role in various models of acute kidney injury (AKI). However, its vancomycin (Van)-induced AKI remains largely unclarified. This study was the first to indicate rapidly activated both human kidney-2 cells and renal tissues, mammalian target rapamycin (mTOR) inactivated via suppression ERK1/2 mTOR during Van treatment. Interestingly, for vitro vivo experiments, chloroquine PT-Atg7-KO significantly ameliorated Van-induced...
The Madeira mealybug, Phenacoccus madeirensis Green, is a serious invasive pest that does significant damage to more than 120 genera of host plants from 51 families in 81 countries. However, the potential distribution range this unclear, which could hamper control and eradication efforts. In current study, MaxEnt models were developed forecast future mealybug around world. Moreover, species was projected for 2050s 2070s under three different climate change scenarios (HADGEM2-AO, GFDL-CM3,...
Our previous study demonstrated that the methyl-CpG-binding domain protein 2 (MBD2) mediates vancomycin (VAN)-induced acute kidney injury (AKI). However, role and regulation of MBD2 in septic AKI are unknown. Herein, was induced by lipopolysaccharide (LPS) Boston University mouse proximal tubules (BUMPTs) mice. For both vitro vivo experiments, we showed inhibition small interfering RNA (siRNA) MBD2-knockout (KO) substantially improved survival rate attenuated LPS cecal ligation puncture...
Abstract Recent studies reported that Methyl-CpG–binding domain protein 2 (MBD2) promoted M2 macrophages accumulation to increase bleomycin-induced pulmonary fibrosis. However, the role and mechanism of action MBD2 in differentiation renal fibrosis remain largely unknown. In current study, not only resting M0 polarized macrophages, but also induced them M1 transition macrophages. ChIP analysis demonstrated physically interacted with promoter region CpG islands G0S2 genes, then activated...
The pathogenesis of Diabetic kidney disease(DKD) involves pathological changes in both tubulo-interstitium and the glomerulus. Surprisingly, tubulo-interstitial fibrosis (TIF), does not develop significantly until late stage DKD. Here, it is demonstrated that PR domain-containing 16 (PRDM16) a key to low level TIF In experiments, PRDM16 upregulated high glucose-treated renal tubular cells, DKD mouse kidneys, biopsy human patients via activation NF-κB signal pathway. High glucose-induced...
Background Population health attributes (such as disease incidence and prevalence) are often estimated using sentinel hospital records, which subject to multiple sources of uncertainty. When applied these attributes, commonly used biased estimation techniques can lead false conclusions ineffective intervention control. Although some estimators account for measurement error (in the form white noise, usually after de-trending), most mainstream statistics cannot generate unbiased minimum...
In this study, we investigated the role of circular RNA_30032 (circRNA_30032) in renal fibrosis and underlying mechanisms. The study was carried out using TGF-β1-induced BUMPT cells unilateral ureteral obstruction (UUO)-induced mice, respectively, as vitro vivo models. CircRNA_30032 expression significantly increased by 9.15- 16.6-fold on days 3 7, tissues UUO model mice. TGF-β1-treated cells, circRNA_30032 induced activation p38 mitogen-activated protein kinase signaling pathway....
Abstract Although previous studies have revealed that long noncoding RNAs (lncRNAs) regulate the progression of ischemic acute kidney injury (AKI), exact role and mechanism lncRNA ENSMUST_147219 in AKI are not clear. In present study, was induced by vitro vivo. Functionally, mediated apoptosis mouse proximal tubule‐derived cell line (BUMPT). Mechanistically, sponged microRNA (miR)-221-5p to upregulate expression interferon regulatory factor 6 (IRF6) drive apoptosis. Finally, knockdown...