A5100336564- Cancer-related molecular mechanisms research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Spectroscopy and Chemometric Analyses
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Mass Spectrometry Techniques and Applications
- Escherichia coli research studies
- Extracellular vesicles in disease
- GABA and Rice Research
- Glycosylation and Glycoproteins Research
- Infant Nutrition and Health
- Congenital gastrointestinal and neural anomalies
- RNA modifications and cancer
- Intestinal Malrotation and Obstruction Disorders
- Advanced Proteomics Techniques and Applications
- DNA and Nucleic Acid Chemistry
- Bacteriophages and microbial interactions
- Ferroptosis and cancer prognosis
- Essential Oils and Antimicrobial Activity
- RNA regulation and disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
BGI Group (China)
2017-2025
Chinese Academy of Sciences
2025
Shenzhen Third People’s Hospital
2025
Southern University of Science and Technology
2025
Panyu District Central Hospital
2025
Guangzhou Medical University
2025
Second Affiliated Hospital of Zhejiang University
2025
Hubei Provincial Hospital of Traditional Chinese Medicine
2021-2024
Guangxi Medical University
2023-2024
Rationale: Ureteral obstruction-induced hydronephrosis is associated with renal fibrosis and progressive chronic kidney disease (CKD). Exosome-mediated cell-cell communication has been suggested to be involved in various diseases, including fibrosis. However, little known regarding how exosomes regulate obstructed kidneys. Methods: We first examined the secretion of UUO (unilateral ureteral obstruction) mouse kidneys TGF-β1-stimulated tubular epithelial cells (NRK-52E). Exosomes from NRK-52E...
Abstract Immune checkpoint blockade (ICB) is emerging as an efficient strategy for cancer immunotherapy, which highly relies on the controlled loading and release of immune checkpoints inhibitors. Herein, a responsive DNA hydrogel containing polyvalent aptamers dual‐target inhibitors reported to achieve ICB localized immunotherapy. This constructed by two ultralong chains generated via rolling circle amplification (RCA), contained (PD‐1 CTLA‐4 aptamers), loaded with inflammatory‐responsive...
In this paper, we investigated the feasibility of using surface enhanced Raman spectroscopy (SERS) blood serum to discriminate liver cancer and cirrhosis patients from normal people. Serum taken 44 healthy people, 45 patients, 42 post-treatment was measured. SERS peaks these groups were compared assignments biomedical meanings analyzed explained. addition, support vector machine (SVM), partial least square-discriminant analysis (PLS-DA) artificial neural networks (ANN) used on obtained...
In this study, surface enhanced Raman spectroscopy (SERS) was used to investigate the spectral characteristics of blood serum for purpose diagnosing stomach diseases. SERS data collected from patients with atrophic gastritis, both pre‐operation and post‐operation gastric cancer, healthy individuals. Visual differences in spectra were observed between four groups which indicate corresponding biomolecule concentration changes blood. To further diagnostic ability human serum, analyzed three...
Ornithine decarboxylase (ODC) plays an important role in various biological processes; however, its plant secondary metabolism, especially the biosynthesis of tropane alkaloids (TAs) such as pharmaceutical hyoscyamine, anisodamine, and scopolamine, remains largely unknown. In this study, we characterized physiological metabolic functions ODC gene Atropa belladonna (AbODC) determined TA production using engineering approaches. Feeding assays with enzyme inhibitors indicated that ODC, rather...
Thyroid cancer is one of the most common malignant tumors, and mortality rate associated with thyroid has been increasing annually. Curcumin reported to exert an antitumor effect on papillary (PTC), identification additional mechanisms underlying anticancer curcumin PTC requires further investigation. The present study aimed explore effects viability, migration invasion cells. TPC‑1 cells were incubated different concentrations curcumin, then, cell invasion, wound healing examined by CCK‑8,...
Ritlecitinib at 50 mg QD showed promising efficacy and acceptable safety in Chinese patients with moderate-to-severe AA, regardless of previous JAKi therapy.
This study investigates the reproductive protective effect and potential mechanism of Cistanches Herba extract(CHE) on a rat model kidney-Yang deficiency induced by adenine. Rats were randomly divided into five groups: normal, model, low-dose CHE(0.6 g·kg~(-1)·d~(-1)), high-dose CHE(1.2 L-carnitine(100 mg·kg~(-1)·d~(-1)). The rats administered adenine(200 mg·kg~(-1)·d~(-1)) gavage for first 14 days to induce deficiency, while simultaneously receiving drug treatment. After days, modeling was...
Human Proteome Project (HPP) aims at mapping entire human proteins with a systematic effort upon all the emerging techniques, which would enhance understanding of biology and lay foundation for development medical applications. Until now, 2563 missing (MPs, PE2-4) are still undetected even using most sensitive approach protein detection. Herein, we propose that enrichment low-abundance benefits MPs finding. ProteoMiner is an equalizing technique by reducing high-abundance enriching in...
HOMER family scaffolding proteins (HOMER1-3) play critical roles in the development and progression of human disease by regulating assembly signal transduction complexes response to extrinsic stimuli. However, role protein breast cancer remains unclear.
A Gram-stain-negative, aerobic, motile and rod-shaped bacterium, strain ZMN-3T, was isolated from desert soil sample collected Ongniod Qi, Inner Mongolia, China. Phylogenetic analysis based on 16S rRNA gene sequences showed that ZMN-3T affiliated with the genus Massilia highest similarity to humi THG S6-8T (98.9 %) buxea A9T (98.2 %). In partial gyrB lepA sequences, of M. were 95.9 96.8 %, respectively. The DNA-DNA hybridization value between its closely related type strains all below 70 %....