A5100683704- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Oral health in cancer treatment
- Atherosclerosis and Cardiovascular Diseases
- Effects of Radiation Exposure
- Cholesterol and Lipid Metabolism
- Saffron Plant Research Studies
- Medical Imaging Techniques and Applications
- Colorectal Cancer Screening and Detection
- Adipokines, Inflammation, and Metabolic Diseases
- Medicinal Plant Pharmacodynamics Research
- Cancer Cells and Metastasis
- Oxidative Organic Chemistry Reactions
- Kawasaki Disease and Coronary Complications
- Plant chemical constituents analysis
- Cardiovascular Health and Risk Factors
- Facial Rejuvenation and Surgery Techniques
- Helicobacter pylori-related gastroenterology studies
- Hydrogen's biological and therapeutic effects
- Analytical Chemistry and Chromatography
- Fibroblast Growth Factor Research
- Colorectal Cancer Treatments and Studies
- Optimism, Hope, and Well-being
- Phytochemical Studies and Bioactivities
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Second Xiangya Hospital of Central South University
2023-2024
Central South University
2023-2024
Institute of Hematology & Blood Diseases Hospital
2022-2023
Sichuan University
2017-2023
Capital University of Physical Education and Sports
2023
Nantong University
2022
Taizhou People's Hospital
2022
University of Ottawa
2022
Jilin Medical University
2021
Hematopoietic and intestinal systems side effects are frequently found in patients who suffered from accidental or medical radiation exposure. In this case, we investigated the of gut microbiota produced-valeric acid (VA) on radiation-induced injuries.Mice were exposed to total body irradiation (TBI) abdominal (TAI) mimic clinical scenarios. High-performance liquid chromatography (HPLC) was performed assess short-chain fatty acids (SCFAs) fecal pellets. Oral gavage with VA used mitigate...
Although radiation therapy is a cornerstone of modern management malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality survivors even shortens their lifespan. Hydrogen has been shown protect against tissue injuries caused by oxidative stress excessive inflammation, but its effect on radiation-induced intestinal injury was previously unknown. In present study, we...
Radiotherapy is inevitably intertwined with various side effects impairing the quality of life cancer patients. Here, we report possibility that alterations oral microbiota influence therapeutic efficacy and prognosis radiotherapy for primary rectal colorectal (CRC) liver metastases pathologically disrupt gastrointestinal integrity function. 16S rRNA sequencing shows change gut bacterial composition within tumors but not in adjacent peritumor tissues CRC mouse models. Specifically, buccal...
Zhibai dihuang pill is a famous traditional Chinese medicine formula containing the herbal Phellodendri amurensis cortex. In this work, an integrative pattern recognition approach including principal component analysis and orthogonal partial least squared discriminant based on ultra-performance liquid chromatography coupled to MS was successfully applied for rapid discovery of natural compounds from medicines. 24 min analysis, 93 were identified or tentatively characterized their...
Oral mucositis is a common radiotherapy-induced complication among nasal, oral and laryngeal cancer (NOALC) patients. This leads to decreased quality of life has few treatments. Here, fractionated radiation was performed mimic radiotherapy for NOALCs in mouse models. microbiota transplantation (OMT) mitigated mucositis, as judged by reconstructed epithelium tongue papillae, fewer infiltrated leukocytes more proliferative cells the epithelium. The gut impacted progression, OMT restructured...
Recent studies have suggested that miR-590 may play critical roles in cardiovascular disease. This study was designed to determine the effects of on lipoprotein lipase (LPL) expression and development atherosclerosis apolipoprotein E knockout (apoE−/−) mice explore potential mechanisms. En face analysis whole aorta revealed significantly decreased aortic atherosclerotic plaque size lipid content apoE−/− mice. Double immunofluorescence staining cross-sections proximal showed agomir reduced...
Abstract Aim This research aimed to explore the level of hope and symptom burden breast cancer women undergoing chemotherapy, predictive factors were also investigated. Background Chemotherapy brings physical psychological stress patients. As an effective coping strategy, gives them courage overcome difficulties improve prognosis survival. Therefore, efforts are needed raise hope. Design/Methods A total 450 who chemotherapy participated in this cross‐sectional study. Sociodemographic data,...
EYA4, one of the four members EYA gene family, is associated with several human cancers. However, its biological functions and molecular mechanisms in progression cancer, particularly esophageal squamous cell carcinoma (ESCC), remain unknown. In present study, we found that EYA4 was underexpressed hypermethylated most ESCC lines tested (85.7%, 6/7). Treatment 5‐aza‐dC and/or trichostatin A (TSA) restored expression lines, which indicates epigenetically regulated. Similarly, aberrantly...
This study investigates the reproductive protective effect and potential mechanism of Cistanches Herba extract(CHE) on a rat model kidney-Yang deficiency induced by adenine. Rats were randomly divided into five groups: normal, model, low-dose CHE(0.6 g·kg~(-1)·d~(-1)), high-dose CHE(1.2 L-carnitine(100 mg·kg~(-1)·d~(-1)). The rats administered adenine(200 mg·kg~(-1)·d~(-1)) gavage for first 14 days to induce deficiency, while simultaneously receiving drug treatment. After days, modeling was...
Type 2 diabetes mellitus (T2DM) and anemia are related to some cardiovascular diseases can predict poor outcomes. Both of them damage the heart in their own ways, but combined effects have not been well explored. This study aimed explore T2DM interaction between left atrial (LA) ventricular (LV) function by cardiac magnetic resonance (CMR).
Full scan mode of liquid chromatography-mass spectrometry equipped with an electrospray ionization source offers a chance on global detection complicated components; however, the carries significant challenges in rapidly capturing information analysts. Sodiation-based in-source collision was proposed here, as technique for rapid detecting untargeted analytes full analysis, which based stability sodium adducts and nonselectivity collision. Then applied to profile angular-type pyranocoumarins...