Abstract Long noncoding RNAs (lncRNAs) participate in cancer immunity. We characterized the clinical significance of an immune-related lncRNA model and evaluated its association with immune infiltrations chemosensitivity bladder cancer. Transcriptome data specimens were employed from The Cancer Genome Atlas. Dysregulated lncRNAs screened via Pearson correlation differential expression analyses, followed by recognition pairs. Then, a LASSO regression was constructed, receiver operator...

Bladder cancer (BLCA) is one of the most common urinary tract malignant tumors. It associated with poor outcomes, and its etiology pathogenesis are not fully understood. There great hope for immunotherapy in treating many tumors; therefore, it worthwhile to explore use BLCA.Gene expression profiles clinical information were obtained from The Cancer Genome Atlas (TCGA), immune-related genes (IRGs) downloaded Immunology Database Analysis Portal. Differentially-expressed survival-associated...

Objective: In order to predict the prognosis in patients with clear cell renal carcinoma (ccRCC) so as understand cancer lipid metabolism and sensitivity immune-targeting drugs, model algorithms were used establish a risk coefficient of long non-coding RNAs (lncRNAs) associated metabolism. Methods: The transcriptome data retrieved from TCGA, lncRNAs obtained through Pearson correlation differential expression analyses. Differentially expressed metabolism-related lncRNA pairs using R language...

5-fluorouracil (5-Fu) metabolism associated enzyme, methylenetetrahydrofolate reductase (MTHFR)'s polymorphism C677T can affect enzyme activity and a series of studies have been performed to examine the association this MTHFR with clinical outcomes gastric cancer (GC) patients treated 5-Fu based chemotherapies. However, results are inconsistent inconclusive. Therefore, more comprehensive summary like meta-analysis on topic is needed. We systematic literature search PubMed Embase up May 20,...

Bladder cancer (BCa) is a remarkably malignant and heterogeneous neoplastic disease, its prognosis prediction still challenging. Even with the mounting researches on mechanisms of tumor immunotherapy, prognostic value T-cell proliferation regulators in bladder remains elusive.Herein, we collected mRNA expression profiles relevant clinical information sufferers from publicly available data base. Then, LASSO Cox regression model was utilized to establish multi-gene signature for TCGA cohort...

Objective: Using model algorithms, we constructed an immune-related long non-coding RNAs (lncRNAs) risk coefficient to predict outcomes for patients with clear cell renal carcinoma (ccRCC) understand the infiltration of tumor immune cells and sensitivity immune-targeted drugs. Methods: Open genes data were downloaded from The Cancer Genome Atlas Immunology Database Analysis Portal, lncRNAs obtained through Pearson correlation analysis. R language software was used obtain differentially...

Abstract The main route of metastasis bladder urothelial carcinoma is through lymph nodes; however, its exact mechanism remains unclear. In this study, we found an association nucleolar and spindle associated protein 1 (NUSAP1) expression with BUC tissues along node the survival prognosis. A total 178 pathological specimens following radical cancer resection were obtained. NUSAP1 was analyzed by immunohistochemistry. We evaluated correlation between clinicopathological characteristics...

Many studies have drawn their attention to the immunotherapy of bladder urothelial carcinoma in terms immunologic mechanisms human body. These include immunogenicity tumor cells and involvement long non-coding RNA (lncRNA). We constructed a necroptosis-related noncoding (nrlncRNA) risk factor model predict BLCA outcomes calculate correlations with chemosensitivity immune infiltration.Transcriptomic data from specimens were accessed The Cancer Genome Atlas, nrlncRNAs identified by performing...

Background: The incidence of clear cell renal carcinoma (ccRCC) is high and has increased gradually in recent years. At present, due to the lack effective prognostic indicators, prognosis ccRCC patients greatly affected.Necroptosis a type death, along with necrosis considered new cancer treatment strategy. aim this study was construct marker for predicting based on long non-coding RNA (nrlncRNAs) associated necroptosis. Methods: sequence data clinical information from Cancer Genome Atlas...

Abstract Background Numerous studies indicate that the gut microbiome is closely associated with prostate cancer (PCa), however, owing to various confounding factors, causal relationship between microbiota and PCa remains unclear. Methods A two-sample Mendelian randomization (MR) analysis utilized genome-wide association study (GWAS) data on of 18,340 participants GWAS summary statistics involving 46,3010 participants. Inverse variance weighted (IVW) served as primary method, complemented by...

Abstract Background: Bladder cancer (BLCA) is one of the most common urinary tract malignant tumors. It associated with poor outcomes, and its etiology pathogenesis are not fully understood. There great hope for immunotherapy in treating many tumors; therefore, it worthwhile to explore use BLCA. Methods: Gene expression profiles clinical information were obtained from The Cancer Genome Atlas (TCGA), immune-related genes (IRGs) downloaded Immunology Database Analysis Portal....

Due to a lack of knowledge the disease process, papillary renal cell carcinoma (PRCC) has dismal outlook. This research was aimed at uncovering possible biomarkers and underlying principles in PRCC using bioinformatics method. We searched Gene Expression Omnibus (GEO) datasets obtain GSE11151 GSE15641 gene expression profiles PRCC. used R package limma identify differentially expressed genes (DEGs). The online tool DAVID ClusterProfiler software were analyze Ontology Kyoto Encyclopedia Genes...

Objective To analyze the epidemic characteristics of malaria, evaluate effects control measures, and to provide a scientific basis for monitoring malaria in local areas. Methods All epidemiological data situation from 1953 2013 were collected analyzed, calculated incidence rates, analyzed distribution season, region, age, gender, occupation; summarize process. Results Totally 13 675 cases with reported this district 1961, average annual was 43.16 per 100 000. Two peaks had...

Abstract Background Papillary renal cell carcinoma (pRCC) is the second most common subtype of carcinoma, only to clear (ccRCC). Compared with ccRCC, metastatic pRCC has worse outcomes. Copper an essential micronutrient; its accumulation related cancer proliferation, growth, angiogenesis, and metastasis. The abnormal expression long non-coding RNA (lncRNA) plays role in developing pRCC. Our study aimed predict outcomes patients using a prognostic risk coefficient model for...

Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system with high mortality and morbidity. Although E2F2, classical transcription factor implicated in cycle, has been shown to foster tumorigenesis several human cancers, it could not draw satisfy answer referring precise downstream signaling axis RCC development yet. Based on publicly available data from TCGA database, expression patterns SPTLC1 miR-16–5p were identified, either ability predict prognosis patients RCC,...