A5078140437- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Testicular diseases and treatments
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Lipid metabolism and disorders
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Alcohol Consumption and Health Effects
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
Peking University Shenzhen Hospital
2022-2025
Beijing Technology and Business University
2024
Southern University of Science and Technology
2022
Zhongshan Hospital
2015-2020
Fudan University
2015-2020
Sun Yat-sen University
2018-2020
The First Affiliated Hospital, Sun Yat-sen University
2018-2020
Fuzhou University
2019
Neutrophils can either promote or inhibit tumor progression, depending on the microenvironment, via release of cytokines. Neither factors produced by tumor-associated neutrophils (TANs) nor their effects progression have been characterized. We investigated roles TANs in hepatocellular carcinoma (HCC) using cell lines and immune cells isolated from patients.We performed studies with HepG2, PLC/PRF/5, MHCC97H, HCCLM3 human Hepa1-6 H22 mouse HCC lines; expression chemokines cytokines were...
Gastric cancer (GC) is a common disease globally with high mortality rate. It therefore necessary to develop novel therapies targeting specific events in the pathogenesis of GC. Some hnRNP family members are involved multiple biological behaviors. However, potential function and mechanism hnRNPR, new molecule GC remains unknown. We found that expression hnRNPR was significantly overexpressed cancers compared normal tissues. Functionally, promoted cell proliferation, migration, invasion....
Natural killer (NK) cell can inhibit tumor initiation and regulates metastatic dissemination, acting as key mediators of the innate immune response. Intrinsic factors modulating NK cells infiltration its anticancer activity remain poorly characterized. We investigated roles dysregulation micro(mi)RNAs in progression hepatocellular carcinoma (HCC). Methods: Small RNA sequencing were used to detect miRNA profiles tissues from HCC patients with (n=14) or without (n=13) pulmonary metastasis...
A high preoperative peripheral blood neutrophil-to-lymphocyte ratio (NLR) has been reported to be a predictor of poor survival in patients with various cancers. The aim this study was evaluate the predictive significance NLR undergoing hepatectomy for intrahepatic cholangiocarcinoma (ICC). From 2005 2011, 322 who underwent ICC were enrolled retrospective study. Clinicopathological parameters, including NLR, evaluated identify predictors overall and recurrence-free after hepatectomy. best...
Background & AimsCancer stemness and immune evasion are closely associated play critical roles in tumor development resistance to immunotherapy. However, little is known about the underlying molecular mechanisms that coordinate this association.MethodsThe expressions of heterogeneous nuclear ribonucleoprotein M (HNRNPM) 240 hepatocellular carcinoma (HCC) samples, public databases, liver databases were analyzed. Chromatin immunoprecipitation assays performed explore associations between...
Abstract Background Fatty acid (FA) metabolism is considered the emerging cause of tumor development and metastasis, driving poor prognosis. Long non-coding RNAs (lncRNAs) are closely related to cancer progression play important roles in FA metabolism. Thus, discovery metabolism-related lncRNA signatures predict outcome immunotherapy response critical improving survival patients with hepatocellular carcinoma (HCC). Methods scores a signature were constructed using single-sample gene set...
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors. Cell division cycle associated 8 (CDCA8) an important multifactorial regulator in cancers. However, its up and downstream targets effects HCC are still unclear.A comprehensive bioinformatics analysis was performed using The Cancer Genome Atlas dataset (TCGA) to explore novel core oncogenes. We quantified CDCA8 levels tumors qRT-PCR. cell's proliferative, migratory, invasive abilities were detected a Counting Kit-8...
Significant advancements have been made in hepatocellular carcinoma (HCC) therapeutics, such as immunotherapy for treating patients with HCC. However, there is a lack of reliable biomarkers predicting the response to therapy, which continues be challenging. Cancer stem cells (CSCs) are involved oncogenesis, drug resistance, and invasion, well metastasis HCC cells. Therefore, this study, we aimed create an mRNA expression-based stemness index (mRNAsi) model predict immunotherapy.
// Zhi-Qiang Hu 1, * , Shao-Lai Zhou Zheng-Jun 1 Chu-Bin Luo Er-Bao Chen Hao Zhan Peng-Cheng Wang Zhi Dai Jian Jia Fan Xiao-Wu Huang Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Invasion, Ministry Education, Shanghai 200032, China These authors have contributed equally to this work Correspondence to: Huang, email: huang.xiaowu@zs-hospital.sh.cn Keywords: hepatocellular carcinoma, semaphorin 3A, tumor-associated macrophages, prognosis...
Our previous study demonstrated that heterogeneous nuclear ribonucleoprotein AB (HNRNPAB) is a key gene facilitates metastasis of hepatocellular carcinoma (HCC). However, the molecular mechanisms behind this relationship are not fully understood. In our study, we utilized long-noncoding RNA (lncRNA) microarrays to identify HNRNPAB-regulated lncRNA named lnc-ELF209. findings from chromatin immunoprecipitation assays indicate HNRNPAB represses lnc-ELF209 transcription by directly binding its...
The aim of this study was to assess the diagnostic performance radiological imaging in differentiating xanthogranulomatous cholecystitis (XGC) from gallbladder cancer (GBC).A retrospective analysis performed patients who had pathologically confirmed XGC or GBC between December 2004 April 2016 performed. sensitivity, specificity, positive predictive value (PPV), and negative (NPV) each modality, combined modalities were calculated.A total 218 (XGC =109, =109) identified; 19 received all...
The expression of sphingomyelin phosphodiesterase 4 (SMPD4), a neutral enzyme, is intricately associated with tumorigenesis and progression. However, its role in hepatocellular carcinoma (HCC) remains unclear. This study mainly reports the expression, prognostic value tumor biological function SMPD4 HCC. Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) International Consortium (ICGC) databases were utilized to investigate patterns SMPD4. Survival Analyses using Kaplan-Meier method...
Jiuzao, the residue from Baijiu production, has shown radical scavenging properties in prior investigations, suggesting its potential as a hepatoprotective agent against acute liver damage. This study reveals that Jiuzao polysaccharides ameliorated morphological damage zebrafish larvae afflicted with alcoholic fatty disease (AFLD), evidenced by Oil red O, H&E, and Nile staining. These notably modulated antioxidant enzyme levels lipid peroxidation components. The real-time quantitative...
Background/Aims: Breast cancer is a common cause of mortality throughout the world. The cross-talk between cells and interstitial exerts significant effects on neoplasia tumor development modulated in part by chemokines. CXC one four chemokine families involved mediating survival, angiogenesis, immunosensitization chemoattracting leukocytes, it incentivizes cell growth, invasion metastasis microenvironment. However, differential expression profiles prognostic values these chemokines remains...
Alpha-fetoprotein-producing gastric cancer (AFPGC) and hepatoid adenocarcinoma of stomach (HAS) are rare types cancer, with specific clinical manifestations poor prognosis. The standardized treatment process such cancers remains elusive. We aim to investigate the efficacy immunotherapy combined chemotherapy on patients AFPGC or HAS.AFPGC HAS who underwent and/or as first-line at our institute from June 2016 December 2018 were enrolled in this observational study. Their clinicopathological...
Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is still a challenge determine patients' prognosis. We aim identify new prognostic markers for resected HCC patients. 274 patients were retrospectively identified samples collected from Zhongshan hospital, Fudan University. analyzed gene expression patterns tumors compared with patient survival times. "9-gene signature" associated by using coefficient regression formula multivariate Cox model. This signature...
Both hepatoid adenocarcinoma of stomach (HAS) and alpha-fetoprotein-positive gastric cancer (AFPGC) are rare but aggressive subtypes cancer, few studies focus on the clinicopathologic differences prognostic factors between them because their rarity histologic overlap. And significance AFP level in HAS prognosis was not well studied.41 patients with AFPGC 52 were included this study. The features compared by Chi-square analysis. Prognostic for overall survival (OS) disease-free (DFS) analyzed...
BACKGROUND Heterotopic pancreas (HP) refers to pancreatic tissue located in areas with no vascular or anatomical connection the pancreas. HP occurs mostly stomach, duodenum, and colon, rarely gallbladder. CASE SUMMARY A 57-year-old woman was referred our hospital complaining of right upper quadrant discomfort for 3 years. An abdominal computed tomography scan revealed adenomyomatosis a thickened fundus The patient underwent laparoscopic cholecystectomy, pathological examination unexpectedly...
Abstract High‐throughput messenger RNA (mRNA) analysis has become a powerful tool for exploring tumor recurrence or metastasis mechanisms. Here, we constructed signature to predict the risk of Stages II and III gastric cancer (GC) patients. A least absolute shrinkage selection operator method Cox regression model was utilized construct signature. Using this method, 16‐mRNA identified be associated with relapse‐free survival GCs in training dataset GSE62254 ( n = 194). Then validated an...