Background Tumor-associated neutrophils (TANs) and macrophages (TAMs) can each influence cancer growth metastasis, but their combined effects in intrahepatic cholangiocarcinoma (ICC) remain unclear. Methods We explored the distributions of TANs TAMs patient-derived ICC samples by multiplex immunofluorescent staining tested separate on vitro vivo. then investigated mechanistic basis using PCR array, western blot analysis ELISA experiments. Finally, we validated our results a tissue microarray...

Importance BRAF variants are associated with tumor progression; however, the prevalence of variant subtypes and their association disease characteristics, prognosis, targeted therapy response in patients intrahepatic cholangiocarcinoma (ICC) largely unknown. Objective To explore ICC. Design, Setting, Participants In this cohort study, 1175 who underwent curative resection for ICC from January 1, 2009, through December 31, 2017, were evaluated at a single hospital China. Whole-exome...

Abstract Increasing numbers of evidences have demonstrated that microRNAs (miRNAs) are implicated in metastasis and progression hepatocellular carcinoma (HCC). However, their detailed expression levels actual functions HCCs not been fully clarified yet. Results from our recent study revealed some miRNAs were particularly related to HCCs. As one these newly found miRNAs, miR-501-3p showed highly involve into metastatic process Here we reported the was decreased both HCC cell lines tissue...

Gesture air-writing is an advanced nontouching interaction method that replaces traditional typewriter keyboards, touch screens and other input devices. Due to its low power consumption, noncontact detection independence from light conditions, millimeter wave radar has become a valuable gesture solution. In this paper, we proposed prototype of tracking system based on the 24-GHz frequency-modulated continuous-wave (FMCW) system-on-chip (SoC). The transmitted chirp signal chip covers up 4-GHz...

<h3>Importance</h3> <i>KRAS</i>variants are associated with tumor progression; however, the prevalence of<i>KRAS</i>variant subtypes and their association survival recurrence in patients intrahepatic cholangiocarcinoma (ICC) after curative resection largely unknown. <h3>Objective</h3> To explore prognostic ICC. <h3>Design, Setting, Participants</h3> In this cohort study, who underwent for ICC from January 2009 through December 2016 at a single hospital China were recruited, whole-exome...

// Zhi-Qiang Hu 1, * , Shao-Lai Zhou Zheng-Jun 1 Chu-Bin Luo Er-Bao Chen Hao Zhan Peng-Cheng Wang Zhi Dai Jian Jia Fan Xiao-Wu Huang Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Invasion, Ministry Education, Shanghai 200032, China These authors have contributed equally to this work Correspondence to: Huang, email: huang.xiaowu@zs-hospital.sh.cn Keywords: hepatocellular carcinoma, semaphorin 3A, tumor-associated macrophages, prognosis...

In this paper, an Uncertainty-based Multi-disciplinary Design Optimization (UMDO) method combining with fuzzy theory and Multi-Discipline Feasible (MDF) is developed for the conceptual design of a Hybrid Rocket Motor (HRM) powered Launch Vehicle (LV). proposed, membership functions are used to represent uncertain factors, statistical experiment introduced analyze propagation uncertainties, means, standard deviations credibility measures delineate responses. A geometric programming problem...

As artificial intelligence technology advances, the application of object detection in field SAR (synthetic aperture radar) imagery is becoming increasingly widespread. However, it also faces challenges such as resource limitations spaceborne environments and significant uncertainty intensity interference scenarios. These factors make performance evaluation key to ensuring smooth execution tasks. In face complex harsh scenarios, methods that rely on single-dimensional assess models have had...

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma, with poor prognosis and limited treatment options. The genomic features of ICC in Chinese patients remain largely unknown. In this study, we perform deep whole-exome sequencing 204 ICCs characterize alterations clonal evolution, reveal their associations patient outcomes. We identify six mutational signatures, including Signatures A F, which are highly similar to...

The linear velocity of an arbitrary moving object comprises two orthogonal components with reference to the observing radar, which are radial and transversal velocity. Simultaneous measurement both velocities can provide a complete 2-D movement information for further target detection, tracking, classification. interferometric radar is capable measuring simultaneously, regardless trajectory. However, coupled in due nonlinear processing when there multiple objects field view (FoV), thus...

This paper proposed a multi-objective, multi-disciplinary design optimization and multi-attribute evaluation method for the manned lunar lander descent stage. A system model is established considering multiple disciplines such as propulsion, structure, trajectory cost. With goal of minimizing mass, cost maximizing velocity increment, overall scheme hybrid rocket motors was optimized by altering various grain shapes feed systems, acting an alternative propulsion lander. Under same conditions,...

This paper investigates the problem of UAV detection and tracking using an interferometric radar. Different from various existing work in literature, UAVs are detected tracked by extracting information range 2-D velocities radar measurements. The radial velocity can be estimated performing respective fast-time slow-time FFT to collected data. However, it is insufficient track with only as do not usually fly straight along direction line sight (LoS). Fortunately, we estimate angular...

Improving traffic efficiency and safety is the goal of all countries due to increasingly congested road environment worldwide. The progress intelligence has promoted development transportation industry. As first step intelligence, perception technology an important part realize intelligent transportation. Accurate efficient management systems, such as automatic control lights at urban intersections or highway emergency disposal, need support advanced environmental sensing technology. In...

Underwater autonomous gliders (UAG) such as Slocum electric provide an effective platform and tool for marine coastal scientists to conduct prolonged missions over weeks or months. However, localization of these underneath ocean surface is challenging due the lack inexpensive, underwater positioning sensors. In this paper, we present a dynamic model-based scheme improve estimation UAG. The new approach built on experimentally validated model fused with onboard depth yaw angle sensor...

The linear velocity of an arbitrary moving object comprises two orthogonal components with reference to the observing radar, those are radial and transversal velocity. interferometric radar is capable providing complete 2-D information regardless trajectory. However, velocities coupled in measurement when there multiple objects field view, thus conventional fails measure velocities. In this paper, we propose a new method based on dual-frequency which can transmit high-frequency waveforms for...

The MAGE family member H1 (MAGEH1) belongs to melanoma-associated antigen (MAGE) superfamily. role of MAGEH1 in hepatocellular carcinoma (HCC) is largely undefined.We used quantitative reverse transcription PCR and immunohistochemistry detect expression HCC tissues. CCK-8 assay, wound healing migration assay Transwell Matrigel invasion were measure cell proliferation, ability. was downregulated tumor tissues compared with adjacent normal liver samples from patients recurrence. reduced Low...

Analytical target cascading (ATC) is a method for coordinating hierarchical system design optimization with decomposition-based framework. Since launch vehicle (LV) usually powered by two or more stages of rocket motors, the overall LV clearly has structure, including level (conducted general department) and subsystem motor stage department). In particular, contains stage-divided elements rather than discipline-divided elements. Therefore, ATC inherently suitable LV. This paper presents an...

This paper presents an approach for simultaneous tracking of multiple targets using the interferometric frequency modulated continuous wave (FMCW) radar. A dual-channel receiver FMCW radar is utilized measurement. The trajectory each target estimated separately based on two-dimensional position and velocity, which can be extracted by applying stretch processing time-frequency analysis to echo signals simultaneously. positions velocities are input a Kalman filter improve performance....

In this paper, we studied the hand gesture recognition algorithm based on features extraction under single-frequency continuous wave and two-receiving antenna structure in mm radar. Through radar parameters design signal processing, time-frequency spectrum can be generated by single frequency phase distribution structure. 12 artificial are extracted from after OS-CFAR de-noising method. The support vector machine (SVM) is used to recognize seven defined gestures features, rate reach 93.84%.

The linear velocity of an arbitrary moving target comprises two orthogonal components with reference to the observing radar, namely radial and transversal velocities. can be measured by interferometric radar directly. When measuring multiple targets, there exist cross-terms that have no physical meanings interfere extraction useful frequency. In this paper, we propose a new method utilizing uniform receiving array three antennas based on spatial averaging suppress measure targets...

In this paper, a dual-frequency broadband patch antenna with matched load and capacitive is proposed for GSM/DCS application. It based on common antenna. order to achieve the 900/1800MHz dual-band performance directional radiation, are added into modified As simulated by HFSS13.0 software obtained. The impedance bandwidth 90MHz 200MHz respectively. calculated results were confirmed measurements prototype.