A5101781243- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- RNA and protein synthesis mechanisms
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- Value Engineering and Management
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Single-cell and spatial transcriptomics
- Redox biology and oxidative stress
Zhongshan Hospital
2018-2024
Fudan University
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
Shanghai Jiao Tong University
2015
Bayer (China)
2009
Emerging evidence has demonstrated that alternative splicing a vital role in regulating protein function, but how factors can be regulated remains unclear. We showed the PPM1G, phosphatase, phosphorylation of SRSF3 hepatocellular carcinoma (HCC) and contributed to proliferation, invasion, metastasis HCC. PPM1G was highly expressed HCC tissues compared adjacent normal tissues, higher levels were observed adverse staged HCCs. The correlated with poor prognosis, which further validated TCGA...
Importance BRAF variants are associated with tumor progression; however, the prevalence of variant subtypes and their association disease characteristics, prognosis, targeted therapy response in patients intrahepatic cholangiocarcinoma (ICC) largely unknown. Objective To explore ICC. Design, Setting, Participants In this cohort study, 1175 who underwent curative resection for ICC from January 1, 2009, through December 31, 2017, were evaluated at a single hospital China. Whole-exome...
Lenvatinib, a multi-targeted tyrosine kinase inhibitor (TKI), has proven efficacy as the first-line treatment for patients with advanced hepatocellular carcinoma (HCC). However, there is no standard effective second-line option following progression on lenvatinib therapy. Because of comprehensive coverage therapeutic targets lenvatinib, remission rate other TKI treatments in HCC resistant to quite low.In this study, effectiveness and safety anti-programmed cell death protein-1 (PD-1)...
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma, with poor prognosis and limited treatment options. The genomic features of ICC in Chinese patients remain largely unknown. In this study, we perform deep whole-exome sequencing 204 ICCs characterize alterations clonal evolution, reveal their associations patient outcomes. We identify six mutational signatures, including Signatures A F, which are highly similar to...
The role of marrow microenvironment in the pathogenesis myelodysplastic syndrome (MDS) remains controversial. Therefore, we studied influence bone marrow-derived mesenchymal stromal cells (BMSCs) from patients with different risk types MDS on survival cell lines SKM-1 and MUTZ-1. We first demonstrated that expression Sonic hedgehog (Shh), smoothened (Smo), glioma-associated oncogene homolog 1 (Gli1) was increased patients<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract The thioredoxin domain containing proteins are a group of involved in redox regulation and have been recently reported to be associated with tumor progression. However, the role hepatocellular carcinoma (HCC) remains largely unknown. Here our study, we demonstrated that protein 9 (TXNDC9) was over-expressed HCC promoted We found TXNDC9 expression amplified tissues an advanced grade HCC. And, overexpression correlated poor prognosis Furthermore, by using CRISPR-Cas9 mediated knockout...
Spontaneous rupture is one of the complications hepatocellular carcinoma (HCC) associated with a high mortality rate. Transcatheter arterial chemoembolization (TACE) has been widely used in patients ruptured liver tumors. The aim present study was to evaluate benefits and safety conventional TACE disease prognosis following surgery regard progression spontaneously HCC. clinical data 70 diagnosed spontaneous HCC were retrospectively reviewed. majority adverse reactions that occurred treatment...
Accumulating evidence indicates that tumor heterogeneity is characterized by distinct immunosubtypes. However, prior studies have mainly focused on the functions of T cells. The role tumor-infiltrating B cells in microenvironment hepatocellular carcinoma (HCC) requires further investigation.We conducted an integrative analysis single cell RNA sequencing (scRNA-seq) datasets HCC samples from Gene Expression Omnibus database. We analyzed features normal liver tissue and HCC. Additionally, we a...
The complex mechanistic array underlying the pathogenesis of myelodysplastic syndrome (MDS) is still unclear. Although dysregulations different signaling pathways involved in MDS have been described, identification specific biomarkers and therapy targets remains an important task order to establish novel therapeutic approaches. Here, we demonstrated that Shh pathway active correlated it with disease progression. Additionally, knockdown Gli1 significantly inhibited cell proliferation vitro...
Although transarterial chemoembolization (TACE) has been widely used for treating the spontaneous rupture of hepatocellular carcinoma (HCC), no existing model exists predicting survival. The aim this study was thus to develop and validate a nomogram estimating prognosis in patients with ruptured HCC upon undergoing TACE treatment.This included 55 spontaneously who underwent treatment between January 2015 April 2019. diagnosis based on disruption peritumoral liver capsule surrounding fluid...
Hintergrund: Aufgrund der geographisch stark variierenden Ätiologie des HCC haben wir die Ergebnisse SHARP- und AP-Studie miteinander verglichen, um Wirksamkeit von Sorafenib bei Patienten mit fortgeschrittenem weltweit zu beurteilen. An SHARP-Studie nahmen aus Europa, Nord- Südamerika Australien, an dem asiatisch-pazifischen Raum teil.
Hintergrund: Die wegweisende Phase-III-Studie SHARP (Llovet et al., N Engl J Med, 2008) zeigte die Wirksamkeit und Sicherheit von Sorafenib bei der Behandlung des fortgeschrittenen HCC. Dieses Ergebnis wurde in Asia-Pacific (AP)-Studie Phase III mit einer asiatischen Studienpopulation (Cheng Lancet Oncology, 2009) bestätigt. Wir haben den Erfolg Patienten, an SHARP- AP-Studie teilnahmen prognostisch ungünstige Prädiktoren aufwiesen, miteinander verglichen.
Abstract Background: Although transarterial chemoembolization（TACE）has been widely used for spontaneously ruptured hepatocellular carcinoma (HCC), no existing models can be survival prediction. Thus, the aim of present study was to develop and validate a nomogram risk prediction HCC rupture after TACE treatment. Methods: The medical records patients who underwent chemoembolization therapy from January 2015 April 2019 at our Hospital were retrospectively screened. diagnosed by either imaging...