A5010249333- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- TGF-β signaling in diseases
- Health, psychology, and well-being
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Acupuncture Treatment Research Studies
- Catalytic Processes in Materials Science
- Genomics and Phylogenetic Studies
- Genetic factors in colorectal cancer
- Genetic diversity and population structure
- Complementary and Alternative Medicine Studies
- Neurological Disease Mechanisms and Treatments
- Hippo pathway signaling and YAP/TAZ
- Aldose Reductase and Taurine
- Bone health and treatments
- Viral Infectious Diseases and Gene Expression in Insects
Binzhou Medical University
2023-2025
Binzhou University
2023-2025
University of Chicago
2025
Central South University
2018-2025
Second Xiangya Hospital of Central South University
2025
Chenzhou First People's Hospital
2019-2024
University of South China
2014-2024
University of British Columbia
2024
Ministry of Agriculture and Rural Affairs
2023-2024
Jimei University
2023-2024
SmMYB44 directly binds to the promoter of a spermidine synthase (SPDS) gene and activates its expression, governing biosynthesis resistance bacterial wilt in eggplant.
Graphene is a two-dimensional crystal that stripped from pristine graphite and made of single layer carbon atoms. Containing numerous functional groups, graphene derivatives (GDs) could be easily modified have aroused great attention for potential applications in biomedicine. However, oxide (GO) arouse cell animal toxicity. To screen GDs with high biocompatibility applied biomedicine, general comparison was performed about the toxicities six diverse types surface modification, size, redox...
Abstract Background Fatty acid (FA) metabolism is considered the emerging cause of tumor development and metastasis, driving poor prognosis. Long non-coding RNAs (lncRNAs) are closely related to cancer progression play important roles in FA metabolism. Thus, discovery metabolism-related lncRNA signatures predict outcome immunotherapy response critical improving survival patients with hepatocellular carcinoma (HCC). Methods scores a signature were constructed using single-sample gene set...
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors. Cell division cycle associated 8 (CDCA8) an important multifactorial regulator in cancers. However, its up and downstream targets effects HCC are still unclear.A comprehensive bioinformatics analysis was performed using The Cancer Genome Atlas dataset (TCGA) to explore novel core oncogenes. We quantified CDCA8 levels tumors qRT-PCR. cell's proliferative, migratory, invasive abilities were detected a Counting Kit-8...
Constitutive activation of the nuclear factor-kappaB (NF-kappaB) transcription factor plays a key role in chronic colonic inflammation and colon tumorigenesis. However, mechanisms by which tightly regulated NF-kappaB pathway becomes constitutively activated during pathogenesis remain obscure. Here, we report that PDLIM2, an essential terminator activation, is repressed various human colorectal cancer cell lines, suggesting one important mechanism for constitutive NF-kappaB. Indeed,...
Resveratrol (Rev) can ameliorate cytotoxic chemotherapy-induced toxicity and oxidative stress. Arsenic trioxide (As2O3) is a known environmental toxicant potent chemotherapeutic agent. However, the mechanisms by which resveratrol protects liver against effects of As2O3 are not known. Therefore, in present study we investigated involved action using cat model hepatotoxicity was induced means treatment. We found that pretreatment with resveratrol, administered clinically comparable dose...
Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found vegetal dietary sources that has antioxidant and chemopreventive properties, trioxide (As2O3)-induced Male Wistar rats.Adult rats received 3 mg/kg As2O3 (intravenous injection, iv.) on alternate days for 4 days. Resveratrol (8 mg/kg) administered (iv.) 1 h before treatment. The plasma homogenization enzymes...
Abstract Despite recent technological advancements in cell tumor DNA (ctDNA) mutation detection, challenges persist identifying low-frequency mutations due to inadequate sensitivity and coverage of current procedures. Herein, we introduce a super-sensitivity specificity technique for detecting ctDNA mutations, named HiCASE. The method utilizes PCR-based CRISPR, coupled with the restriction enzyme. In this work, HiCASE focuses on testing series EGFR provide enhanced detection technology...
Superparamagnetic iron oxide nanoparticles (SPIONs) have been developed as excellent magnetic resonance imaging (MRI) contrast agents for stem cell labeling and tracking due to their biocompatibility. In this study, we designed a self-assembled peptide amphiphile (PA) with potential use in tissue engineering drug delivery applications. This PA was conjugated the surfaces of SPIONs label rat mesenchymal cells (MSCs), which enhanced efficiencies. Studies on labeled showed that peptide-SPIONs...
<title>Abstract</title> IMPORTANCE The COVID-19 pandemic has brought about widespread health and even mortality anxiety, exacerbating negative emotions such as depression, insomnia. OBJECTIVE To determine whether online emotional assessment supported by musicians, psychological experts, psychiatrists, well music therapy applications, can reduce during the pandemic. DESIGN, SETTING, AND PARTICIPANTS This retrospective study collected user data from “Y-muse” WeChat mini-program across 34...
With the development of multifunctional imaging, gadolinium (Gd)-bearing inorganic nanoparticles (NPs), which were doped with trivalent lanthanide (Ln3+), have been applied in magnetic resonance imaging (MRI) and optical owing to their high payload Gd3+ ions specific characteristics. In this study, we chose GdVO4 codoped Eu3+ Bi3+ as host material generate a highly efficient contrast agent (CA) for MRI long-term luminescence imaging. The new CA emits strong stable because its characteristic...
The present study examined SMAD4 expression in fine-needle aspiration cell blocks from patients with breast ductal carcinoma, order to assess its viability as a prognostic marker. Using immunohistochemistry, the protein status of 86 carcinoma biopsies, who underwent tumor resection at Beihua University Affiliated Hospital (Jilin, China) between 2002 and 2008, was characterized. association clinicopathological parameters, well prognosis assessed using Mantel-Haenszel method Cox proportional...
Circular RNAs (circRNAs) are playing emerging role in the pathogenesis of cancers, but mechanisms still unknown. In recent issue Nature Communications, Chen and colleagues have demonstrated that YTHDC1 facilitates N6-methyladenosine modified circNSUN2 cytoplasmic export circNSUN2/IGF2BP2/HMGA2 complex stabilizes HMGA2 to promote colorectal liver metastasis. These discoveries not only expand our understanding circRNAs biology tumor, also demonstrate m6A modification plays a key for RNA...