Abstract Motivation Deep learning-based molecule generation becomes a new paradigm of de novo design since it enables fast and directional exploration in the vast chemical space. However, is still an open issue to generate molecules, which bind specific proteins with high-binding affinities while owning desired drug-like physicochemical properties. Results To address these issues, we elaborate novel framework for controllable protein-oriented generation, named CProMG, contains 3D protein...

Abstract It is a vital step to recognize cyanobacteria promoters on genome-wide scale. Computational methods are promising assist in difficult biological identification. When building recognition models, these rely non-promoter generation cope with the lack of real non-promoters. Nevertheless, factitious significant difference between and non-promoters causes over-optimistic prediction. Moreover, designed for E. coli or B. subtilis, existing cannot uncover novel, distinct motifs among...

Abstract The well-known Falkner–Skan equation is one of the most important equations in laminar boundary layer theory and used to describe steady two-dimensional flow a slightly viscous incompressible fluid past wedge shaped bodies angles related λπ/2, where λ ∈ ℝ parameter involved equation. It known that there exists λ* < 0 such with suitable conditions has at least positive solution for each ≥ no solutions λ*. numerical result shows = –0.1988. In this paper, [–0.4,–0.12] proved...

We prove a new existence result of positive solutions for the Sturm–Liouville problems. Different from existing research, we do not assume that nonlinearity term f has numerical and functional lower bounds or satisfies some usual limit conditions.

We investigate existence of reversed flow solutions the Falkner-Skan equations by considering a system oftwo singular Hammerstein integral equations.We provethat exist for each parameter in $(-1/6,0)$. This is an extension results on nonexistence ofreversed obtained recently authors.As applications our new results, we obtain similarity solutionsof boundary layer governing fluids over surfaces often arising fromengineering problems.

Ureteral stents are widely used. If ureteral remain in place for extended periods, the probability of migration and stone formation increases substantially. However, a 29-year-old stent that was placed did not develop calculus is rare. We reported 45-year-old man admitted with pain left side his waist abdomen more than 10 years. He underwent ureterotomy 29 years prior to admission calculi, postoperatively prevent strictures. The removed hospital due poor compliance on part patient. This...

Abstract Background: Bladder cancer (BLCA) is one of the most common urinary tract malignant tumors. It associated with poor outcomes, and its etiology pathogenesis are not fully understood. There great hope for immunotherapy in treating many tumors; therefore, it worthwhile to explore use BLCA. Methods: Gene expression profiles clinical information were obtained from The Cancer Genome Atlas (TCGA), immune-related genes (IRGs) downloaded Immunology Database Analysis Portal....

This paper studies approximate solutions for a class of nonlinear diffusion population models. Our methods are to use the fundamental solution heat equations construct integral forms models and well-known Banach compression map theorem prove existence positive equations. Non-steady-state local suitable harvest functions obtained by utilizing approximation multivariate continuous functions.