A5088266408- Heat shock proteins research
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Coenzyme Q10 studies and effects
- Endoplasmic Reticulum Stress and Disease
- Microplastics and Plastic Pollution
- RNA Research and Splicing
- Biochemical effects in animals
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Physiological and biochemical adaptations
- Bacteriophages and microbial interactions
- Mercury impact and mitigation studies
- RNA modifications and cancer
- Thermoregulation and physiological responses
- Advanced biosensing and bioanalysis techniques
- Methane Hydrates and Related Phenomena
- Exercise and Physiological Responses
- ATP Synthase and ATPases Research
- Pharmaceutical and Antibiotic Environmental Impacts
- thermodynamics and calorimetric analyses
- Melamine detection and toxicity
- Developmental Biology and Gene Regulation
- Stellar, planetary, and galactic studies
- Nuclear Structure and Function
Henan Normal University
2025
The University of Queensland
2020-2025
Sichuan University
2024
China Pharmaceutical University
2024
State Key Laboratory of Natural Medicine
2024
West China Hospital of Sichuan University
2024
Pennsylvania State University
2023
Zhangzhou Normal University
2021-2023
Westlake University
2023
Dalian Institute of Chemical Physics
2023
Abstract The recently discovered DPANN archaea are a potentially deep-branching, monophyletic radiation of organisms with small cells and genomes. However, the monophyly early emergence various clades their role in life’s evolution debated. Here, we reconstructed analysed genomes an uncharacterized archaeal phylum ( Candidatus Undinarchaeota), revealing that its members have and, while being able to conserve energy through fermentation, likely depend on partner for acquisition certain...
Plastics are inexpensive and widely used organic polymers, but their high durability hinders biodegradation. Polystyrene, including extruded polystyrene (also known as styrofoam), is among the most commonly produced plastics worldwide recalcitrant to microbial degradation. In this study, we assessed changes in gut microbiome of superworms (Zophobas morio) reared on bran, or under starvation conditions over a 3 weeks period. Superworms all diets were able complete life cycle pupae imago,...
Abstract Asgardarchaeota have been proposed as the closest living relatives to eukaryotes, and a total of 72 metagenome-assembled genomes (MAGs) representing six primary lineages in this archaeal phylum thus far described. These organisms are predicted be fermentative heterotrophs contributing carbon cycling sediment ecosystems. Here, we double genomic catalogue by obtaining 71 MAGs from range habitats around globe, including deep subsurface, brackish shallow lakes, geothermal spring...
Heat stress is exacerbated by global warming and affects human animal health, leading to heart damage caused imbalances in reactive oxygen species (ROS) the antioxidant system, acid-base chemistry, electrolytes respiratory alkalosis. Vitamin C scavenges excess ROS, sodium bicarbonate maintains electrolyte balance, alleviates Herein, we explored ability of vitamin alone combination with equimolar (Vitamin C-Na) stimulate endogenous antioxidants heat shock proteins (HSPs) relieve H9C2 cells....
Marine sediments are vast, underexplored habitats and represent one of the largest carbon deposits on our planet. Microbial communities drive nutrient cycling in these sediments, but full extent their taxonomic metabolic diversity remains to be explored. Here, we analysed shallow coastal deep subseafloor sediment cores from 0.01 nearly 600 metres below seafloor, Western Pacific Region. Applying metagenomics, identified several clusters across all samples, which mainly aligned with depth...
CRYAB is a small heat shock protein (sHSP) that has previously been shown to protect the heart against various cellular stresses; however, its precise function in myocardial cell injury caused by stress remains unclear. This study aimed investigate molecular mechanism which protects cardiomyocytes stress. We constructed two H9C2 lines stably express differing degrees: CRYAB-5 and CRYAB-7. Both CRYAB-7 showed significantly reduced granular degeneration vacuolar following compared control...
Heat stress can particularly affect the kidney because of its high rate adenosine triphosphate consumption. Competition between apoptosis and autophagy-mediated survival always exists in damaged tissue. And Hsp90 enhance cellular protection to resist heat stress. However, relationship above competition underlying mechanism are unclear. The present study found that induced obvious histopathological oxidative injury, which was connected with autophagy associated levels expression or function....
Heat stress (HS) often causes sudden death of humans and animals due to heart failure, mainly resulting from the contraction cardiac microvasculature followed by myocardial ischemia. Cardiac microvascular endothelial cells (CMVECs) play an important role in maintaining vasodilatation. Aspirin (ASA) is well known for its protective abilities febrile animals. However, there little knowledge about molecular resistance mechanisms CMVECs which ASA may this context. Therefore, we used a heat model...
Although the toxicity of melamine to kidneys and testes is well known, few studies have investigated effects on female reproductive organs. Therefore, this study explores oral administration or cyanuric acid for 28 days ovaries rats. Rats that were exposed mixture exhibited reduced ovarian uterine weights, a shorter estrous cycle, serum estrogen progesterone levels compared rats control Furthermore, morphological analysis revealed pathological changes in mixture, such as more atretic...
Abstract Heat stress is a major stressor that can lead to male reproductive dysfunction. Sertoli cells play crucial role in spermatogenesis by providing germ with structural and nutritional support, contributing blood–testis barrier formation. Vitamin C (Vc) an antioxidant capable of neutralizing reactive oxygen species preventing lipid peroxidation widely used because it inexpensive highly accessible. In the present study, we investigated protective effect Vc on TM4 following heat stress....
In this report, we investigated the protective function of co-enzyme Q10 on chicken hearts during in vivo heat stress (HS) and relationship with Hsp70 expression. The concentration (Q10) serum indicated that exogenously added prior HS was fully absorbed by chickens is maintained at high levels HS. level heart oxidative damage-associated enzymes revealed treatment decreased activity CK-MB, CK, LDH compared group; moreover, injury also alleviated according to SOD, MDA, T-AOC group stress. A...
The present study aimed to analyze the expression levels and localizations of heat shock protein (HSP) 60 HSP10 in heart tissue rats subjected stress (42°C) for 0, 20, 80 100 min. Histopathological injuries increased serum activities lactate dehydrogenase creatine kinase isoenzyme MB were detected heated rat myocardial cells. These results suggested that stress-induced acute degeneration may be sufficient cause sudden death animals by disrupting function permeability cell membrane. In...
Heat shock protein 90 (Hsp90) is associated with resisting heat‑stress injury to the heart, particularly in myocardial mitochondria. However, mechanism underlying this effect remains unclear. The present study was based on high expression of Hsp90 during heat stress (HS) and involved inducing higher using aspirin mouse hearts. Higher levels inhibited HS‑induced damage apoptosis, mitochondrial dysfunction, by stimulating Akt (protein kinase B) activation PKM2 (pyruvate M2) signaling,...
With the decrease in high-grade chalcopyrite resources, copper extraction from low-grade has attracted more and attention. However, kinetic rates of leaching with traditional oxidants are usually very slow due to formation passivation layer. In this study, a novel reagent chlorinated oxidant, trichloroisocyanuric acid (TCCA), was used leach for first time. The experimental results showed that when initial oxidant concentration TCCA 0.054 mol·L−1, temperature kept at 55 °C, pH pulp controlled...
Abstract RNA-binding proteins (RBPs) containing intrinsically disordered domains undergo liquid-liquid phase separation to form nuclear bodies under stress conditions. This process is also connected the misfolding and aggregation of RBPs, which are associated with a series neurodegenerative diseases. However, it remains elusive how folding states RBPs changes upon formation maturation bodies. Here, we describe SNAP-tag based imaging methods visualize in live cells via time-resolved...
Abstract Embryonic axis formation is essential for patterning and morphogenesis in vertebrates tightly regulated by the dorsal organizer. Previously, we demonstrated that maternally derived Huluwa (Hwa) acts as a determinant, dictating activating β-catenin signaling zebrafish Xenopus . However, mechanism of activation fine regulation Hwa protein remains unclear. Through candidate screening identified mutation at Ser168 PPNSP motif dramatically abolishes its axis-inducing activity....
In this study, we investigated the function of co-enzyme Q10 (Q10) in autophagy primary chicken myocardial cells during heat stress. Cells were treated with (1 μΜ, 10 and 20 μM) before exposure to Pretreatment suppressed decline cell viability stress increase apoptosis Treatment μM upregulated autophagy-associated genes The expression LC3-II was highest Q10. decreased reactive oxygen species (ROS) levels number autophagosomes significantly increased by treatment, as demonstrated electron...