A5006218516- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Bat Biology and Ecology Studies
- Iron Metabolism and Disorders
- Trace Elements in Health
- CRISPR and Genetic Engineering
- Evolution and Genetic Dynamics
- Protist diversity and phylogeny
- Animal Vocal Communication and Behavior
- RNA and protein synthesis mechanisms
- Aquaculture Nutrition and Growth
- Chromosomal and Genetic Variations
- Enzyme Structure and Function
- Methane Hydrates and Related Phenomena
- Marine animal studies overview
- Insect symbiosis and bacterial influences
- Legume Nitrogen Fixing Symbiosis
- Hearing, Cochlea, Tinnitus, Genetics
- Fish Biology and Ecology Studies
- Lysosomal Storage Disorders Research
- Virus-based gene therapy research
- Probiotics and Fermented Foods
University of Tübingen
2021
Uppsala University
2018-2020
Science for Life Laboratory
2019-2020
Max Planck Institute of Molecular Cell Biology and Genetics
2017-2018
Max Planck Institute for the Physics of Complex Systems
2018
Center for Systems Biology Dresden
2018
University of Aberdeen
2014
National University of Malaysia
2011-2014
Abstract The recently discovered DPANN archaea are a potentially deep-branching, monophyletic radiation of organisms with small cells and genomes. However, the monophyly early emergence various clades their role in life’s evolution debated. Here, we reconstructed analysed genomes an uncharacterized archaeal phylum ( Candidatus Undinarchaeota), revealing that its members have and, while being able to conserve energy through fermentation, likely depend on partner for acquisition certain...
A genomic screen uncovers a link between molecular parallelism and the convergent evolution of superfast sound-producing muscles.
Ferritin is a highly-conserved iron-storage protein that has also been identified as an acute phase within the innate immune system. The function mediated through complementary roles played by heavy (H)-chain subunit well light (L) in mammals or middle (M)-chain teleosts, respectively. In this study, we report identification of five ferritin subunits (H1, H2, M1, M2, M3) Atlantic salmon were supported presence iron-regulatory regions, gene structure, conserved domains and phylogenetic...
Metachromatic leukodystrophy (MLD) is a rare genetic disorder caused by mutations in the Arylsulfatase-A (ARSA) gene. The enzyme plays key role sulfatide metabolism brain cells, and its deficiency leads to neurodegeneration. clinical manifestations of MLD include stagnation decline motor cognitive function, leading premature death with limited standard treatment options. Here, we describe mutation-agnostic hematopoietic stem progenitor cell (HSPC) gene therapy using CRISPR-Cas9 AAV6 repair...
Ferritins are ubiquitous, highly-conserved proteins that constitute one of the most important components cellular machinery devoted to management iron levels. Various ferritins have been described in vertebrates, though their exact functions and phylogenetic relationships remain be established. Our attempts properly annotate two ferritin subunits isolated from Asian sea bass Lates calcarifer, prompted us investigate evolutionary among vertebrate with non-vertebrate homologs. We carried out a...
Abstract Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well novel cases (Strc, Tecta, Cabp2) of parallelism echolocating bats toothed whales in proteins that could contribute high frequency hearing adaptations. Interestingly, our screen also showed mammals exhibit an unusually number substitutions fast-twitch muscle fiber...
Introductory paragraph The evolution and diversification of Archaea is central to the history life on Earth. Cultivation-independent approaches have revealed existence at least ten archaeal lineages whose members small cell genome sizes limited metabolic capabilities together comprise tentative DPANN archaea. However, phylogenetic diversity placement various this group in tree remain debated. Here, we reconstructed additional metagenome assembled genomes (MAGs) a thus far uncharacterized...