Zhong Chen

ORCID: 0000-0002-0490-1098
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About
Contact & Profiles
Research Areas
  • Aortic aneurysm repair treatments
  • Venous Thromboembolism Diagnosis and Management
  • Peripheral Artery Disease Management
  • Cerebrovascular and Carotid Artery Diseases
  • Aortic Disease and Treatment Approaches
  • Diagnosis and Treatment of Venous Diseases
  • Infectious Aortic and Vascular Conditions
  • Coronary Interventions and Diagnostics
  • Knee injuries and reconstruction techniques
  • Tendon Structure and Treatment
  • Atherosclerosis and Cardiovascular Diseases
  • Gastric Cancer Management and Outcomes
  • Advanced X-ray and CT Imaging
  • Lung Cancer Treatments and Mutations
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Esophageal Cancer Research and Treatment
  • Trauma and Emergency Care Studies
  • Pelvic and Acetabular Injuries
  • Orthopedic Surgery and Rehabilitation
  • Vasculitis and related conditions
  • Vascular Procedures and Complications
  • Acute Ischemic Stroke Management
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Renal and Vascular Pathologies
  • Cardiac, Anesthesia and Surgical Outcomes

Beijing Anzhen Hospital
2016-2025

Capital Medical University
2016-2025

Sun Yat-sen University
2013-2022

Sun Yat-sen Memorial Hospital
2013-2022

Shanghai Sixth People's Hospital
2022

Shanghai Jiao Tong University
2022

St Peter's Hospital
2021

Beijing Institute of Water
2016-2021

Kunming Medical University
2020

Peking University Shenzhen Hospital
2019

Two receptor pathways are thought to mediate the hepatic clearance of chylomicron remnants, (i) low density lipoprotein (LDLR) pathway and (ii) non-LDLR pathway. The current study was undertaken quantitatively assess contribution each catabolism by using mice that deficient in apolipoprotein E (apoE) (<i>apoE(-/-)</i>), LDLR (<i>LDLR(-/-)</i>), both (<i>apoE(-/-);LDLR(-/-)</i>). Vitamin A fat tolerance tests showed area under curves plasma excursions retinyl ester <i>LDLR(-/-),...

10.1074/jbc.271.37.22422 article EN cc-by Journal of Biological Chemistry 1996-09-01

Bioresorbable scaffolds have emerged as a new generation of vascular implants for the treatment atherosclerosis, and designed to provide temporary scaffold that is subsequently absorbed by blood vessels over time. Presently, there insufficient data on biological mechanical responses accompanied bioresorbable (BRS) degradation. Therefore, it necessary investigate inflexion point degradation, response vessels, pathophysiological process vascular, results such studies will be great value design...

10.1016/j.bioactmat.2021.08.020 article EN cc-by-nc-nd Bioactive Materials 2021-08-24

Background: Although many strategies have been developed to modify the biological and biomechanical environment of meniscal suture repair improve chances healing, failure rates remain high. Thus, new methods promote regeneration are needed. Hypothesis: Administration magnesium (via a using stitches) might enhance recruitment adherence endogenous stem cells site lesion, thereby promoting in situ chondroprotective functions. Study Design: Controlled laboratory study. Methods: Synovial...

10.1177/0363546518820076 article EN The American Journal of Sports Medicine 2019-02-20

Peripheral Artery Disease (PAD) is a common cardiovascular condition marked by peripheral artery stenosis or occlusion. Despite treatment advancements, patients will still face vascular complications, highlighting the need for innovative therapies. Human proteins play crucial roles in biology and drug research. Mendelian randomization (MR) analysis, gene-based method, increasingly used target identification. This study aims to identify PAD-associated plasma through MR analysis potential We...

10.1186/s12959-025-00738-4 article EN cc-by-nc-nd Thrombosis Journal 2025-05-20

The worldwide EINSTEIN DVT and PE studies randomized 8282 patients with acute symptomatic deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) and, for the first time in trials this setting, included China. This analysis evaluates results of these subgroup patients.A total 439 Chinese who had (n=211), or without (n=228), were to receive rivaroxaban (15 mg twice daily 21 days, followed by 20 once daily) standard therapy enoxaparin overlapping an adjusted-dose vitamin K antagonist, 3, 6,...

10.1186/1477-9560-11-25 article EN cc-by Thrombosis Journal 2013-12-01

Abdominal aortic aneurysm (AAA) is an inflammatory vascular disorder with high mortality. Accumulating evidence shows that toll-like receptor 2 (TLR2) plays a critical role in the regulation of wound-repairing process after tissue injury. We wondered if TLR2 signaling contributed to pathogenesis AAA and targeting would attenuate development progression. In this study, enhanced expression its ligands were observed human tissue. Neutralization protected against caused established regress mouse...

10.1016/j.apsb.2015.03.007 article EN cc-by-nc-nd Acta Pharmaceutica Sinica B 2015-04-10

VEIN STEP was conducted to collect international data on the management of chronic venous disease (CVD) and assess effectiveness conservative treatments for relief CVD signs symptoms. This international, observational, prospective, longitudinal, cohort study recruited adult outpatients consulting symptomatic CVD. The primary objective symptoms, quality life in a real-life setting assessed using range patient-reported outcome measures: 10-cm Visual Analog Patient Global Impression Change...

10.1007/s12325-023-02643-6 article EN cc-by-nc Advances in Therapy 2023-09-20

The Sars-Cov-2 infection is a multisystem illness that can affect the cardiovascular system. Tachyarrhythmias have been reported but prevalence of bradyarrhythmia unclear. Cases described transient high-degree atrioventricular (AV) block in COVID-19 were managed conservatively.A database all patients requiring temporary or permanent pacing two linked cardiac centers was used to compare number procedures required during first year pandemic compared corresponding period earlier....

10.1111/pace.14313 article EN Pacing and Clinical Electrophysiology 2021-07-09

To compare the efficacy and feasibility of neoadjuvant chemoradiotherapy with docetaxel plus cisplatin or fluorouracil in treatment local advanced esophageal squamous cell carcinoma.A total 154 cases stage cT3N0-1M0 were randomly assigned to two arms. The arm A received 2 cycles doctaxel 75 mg/m(2) 25 d1-3 40 Gy radiation therapy, B 600 d1 ∼ 5 therapy. surgery was performed 3 - 4 weeks later.Grade 3/4 toxicities occurred 53.2% patients 36.4% (P = 0.035). Neutropenia 20.7% 5.6% 0.004). Nine...

10.3760/cma.j.issn.0253-3766.2012.11.017 article EN PubMed 2012-11-01

This study aimed to explore whether the defect of visual function is a risk factor knee anterior cruciate ligament (ACL) sports injury and provide theoretical basis for primary prevention ACL injury. cross-sectional included 392 participants divided into two groups: group (287 with knee) control (105 healthy volunteers). Participants in were further ACL-Intact (133) ACL-Deficient (154). received questionnaire about conditions their (including action, site condition, weather, contact)...

10.3390/jcm11195602 article EN Journal of Clinical Medicine 2022-09-23

Tetramethylpyrazine, a drug originally isolated from the rhizome of Ligusticum walliichi, is an inhibitor phosphodiesterase and inhibits platelet aggregation smooth muscle cell proliferation. The effect tetramethylpyrazine-eluting stent (TES) on preventing in-stent restenosis was investigated in comparison with control bare metal stents porcine coronary model.The TES prepared by spray-coating 2.5 to 3.0 mm x 15 20 Tetramethylpyrazine monomer, methyl methacrylate copolymer, polyglycolic acid....

10.1097/fjc.0b013e318070c648 article EN Journal of Cardiovascular Pharmacology 2007-08-01
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