A5013941605- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Antibiotic Use and Resistance
- Advanced Memory and Neural Computing
- Clostridium difficile and Clostridium perfringens research
- Burkholderia infections and melioidosis
- Plant Disease Resistance and Genetics
- Vibrio bacteria research studies
- Colorectal Cancer Treatments and Studies
- Enterobacteriaceae and Cronobacter Research
- Fatigue and fracture mechanics
- Silicon Carbide Semiconductor Technologies
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- Parallel Computing and Optimization Techniques
- Advanced Welding Techniques Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Nanoplatforms for cancer theranostics
Yangzhou University
2025
Shantou University
2020-2024
Shantou University Medical College
2020-2024
Chungnam National University
2020
Hebei University
2019
The emergence of pathogens is conferring resistance to last-resort therapies such as tigecycline, colistin, and carbapenems, limiting the therapeutic options, raising concerns about new "superbugs." This study reports first incident a blaNDM-5 tet(X4) co-harboring Escherichia coli with carbapenem tigecycline recovered causative agent urinary tract infection in 94-year-old patient. E. strain ECCL209 carries multiple genes [i.e., blaTEM-1B , blaNDM-5, blaCMY-2, aadA22, florR, erm(B), mph(A),...
Before the emergence of plasmid-mediated colistin resistance, was once considered last drug choice for infections caused by carbapenem-resistant bacteria. Currently, researchers are relentlessly exploring possible alternative therapies that could efficiently curb spread resistance. In this study, we aim to investigate synergistic antibacterial activity tetrandrine in combination with against mcr-1-harboring Escherichia coli. We examined vivo and vitro bacterial cells fluorescence, scanning,...
To investigate the occurrence and molecular features of ESBL-producing colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan.A total 153 E. were 250 faecal samples collected livestock poultry. The antibiotic susceptibility, resistant determinants mobile genetic elements determined for all isolates. clonal relatedness was analysed by MLST. Plasmids harbouring, localization transferability mcr-1 gene carried out Southern hybridization, S1-PFGE...
Object Hospital sewage have been associated with incorporation of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) into microbes, which is considered as a key indicator for the spread antimicrobial (AMR). The compositions dental waste water (DWW) contain heavy metals, evolution AMR its effects on environment in context metal not seriously investigated. Thus, our major aims were to elucidate DWW. Methods DWW samples collected from department. presence microbial...
A smart theranostic prodrug IMC-FDU-TZBC-NO2, releasing active drug on-demand based on hypoxia-activated and indomethacin-mediated, for solid tumor imaging efficient therapy was designed. This constructed by conjugating chemotherapy 5-fluoro-2-deoxyuridine (FDU), targeting moiety indomethacin (IMC), the hypoxic trigger 4-nitrobenzyl group to a fluorescent dye precursor, which mediated IMC activated NTR under conditions. The IMC-TZBCM generated FDU released at same time in cells. rates...
Due to the growing availability of genomic datasets, machine learning models have shown impressive diagnostic potential in identifying emerging and reemerging pathogens. This study aims use techniques develop compare a model for predicting bacterial resistance panel 12 classes antibiotics using whole genome sequence (WGS) data Pseudomonas aeruginosa.A technique called Random Forest (RF) BioWeka was used classification accuracy assessment logistic regression (LR) statistical analysis.Our...
Sheath blight (ShB), caused by the necrotrophic fungus Rhizoctonia solani, is one of most serious rice diseases worldwide. In this study, we successfully grafted salicylic acid (SA) onto mesoporous silica nanoparticles through an amide-bond coupling method, forming functionalized MSN-SA nanoparticles. Physicochemical characterization showed that were spherical, with average particle size approximately 30 nm and SA loading rate around 7.21%. The assessment ShB resistance revealed both MSN-OH...
OBJECTIVE: Intestinal microbiota plays a vital role in the pathogenesis of colorectal cancer (CRC), which is crucial for assessing risk and prognosis CRC. Most studies regarding human gut mainly based on feces, but exact composition vary significantly due to fecal easily affected by many factors. We aim evaluate whether intestinal lavage fluid (IVF) better substitution mirroring microbiota. METHODS: performed 16S rRNA gene analysis IVF samples from 30 CRC patients 25 healthy individuals,...
Aim: The gut microbiome plays a crucial role in colorectal cancer (CRC) tumorigenesis, but compositions of microorganisms have been inconsistent previous studies due to the different types specimens. We investigated microbiomes and resistomes CRC patients with colonic biopsy tissue intestinal lavage fluid (IVF). Methods: Paired samples (biopsy IVF) were collected from 20 CRC, their measured by shotgun metagenomics. Clinical laboratory data recorded. Bioinformatics (KneadData, Kraken2, FMAP)...
Leukemia poses significant challenges to its treatment, and understanding complex pathogenesis is crucial. This study used metagenomic sequencing investigate the interplay between chemotherapy, gut microbiota, antibiotic resistance in patients with acute leukemia (AL). Pre- post-chemotherapy stool samples from revealed alterations microbial richness, taxa, genes (ARGs). The analysis a decreased alpha diversity, increased dispersion samples, changes abundance of specific bacteria. Key...
Background Burkholderia pseudomallei ( B. ) is a highly infectious agent and causes melioidosis, in both humans animals, which endemic Southeast Asia Northern Australia. Objectives This study aims to determine the molecular epidemiology, resistant determinants, genomic diversity of clinical isolates further elucidate phylogenetic evolutionary relationship strains with those other regions. Methods In this study, we obtained eight from Guangdong province 2018 2019. All were sequenced using...
This study aimed to investigate the high-resolution phenotypic and genotypic characterization of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli strains isolated from hospitalized patients explore resistance genes mobile genetic elements (MGEs) involved in horizontal dissemination.Between May September 2021, a total 216 ESBL-producing E. isolates were recovered multiple departments. The identification was performed using MALDI-TOF mass spectrometry PCR, while antibiotic...
Abstract Aim : Clinical antimicrobial resistance (AMR) is a significant threat to public health, which often unclear due representative data from human populations that are challenging obtain. Study the associations between consumption of antibiotics and bacteria or genes (ARB ARGs) will benefit elucidating AMR. Methods The details usage were calculated based on actual in target hospital, ARB was detected by culture method, ARGs evaluated metagenomics. Results: Our study revealed...
Aim: Exosomes are frequently used for characterization of diseases, e.g., viral infections, but have not been reported COVID-19. The aims our study were to determine exosomes' novel applications SARS-CoV-2 RNA infection and prognosis COVID-19 disease.Methods: From 15 patients five healthy controls, 32 serum samples collected by clinicians in Wuhan, China. purified, their RNAs (exoRNAs) isolated analyzed using RT-PCR the presence N and/or ORF1ab genes, human RNaseP gene as reference.Results:...
Compute-in-memory (CIM) presents an attractive approach for energy-efficient computing in data-intensive applications. However, the development of suitable memory designs to achieve high-performance CIM remains a challenging task. Here, we propose cryogenic quasi-static embedded DRAM address logic-memory mismatch CIM. Guided by re-calibrated device model, designed four-transistor bit-cell achieves full-swing data storage, low power consumption, and extended retention time at temperatures....
This paper outlines the establishment of a generic cryogenic CMOS database in which key electrical parameters and transfer characteristics MOSFETs are quantified as functions device size, temperature/frequency responses. Meanwhile, comprehensive statistical study is conducted to evaluate influence variation mismatch effects at low temperatures. Furthermore, by incorporating Cryo-CMOS compact model into process design kit (PDK), 4 Kb SRAM, 5-bit flash ADC 8-bit current steering DAC designed,...