A5114080173- Protein Structure and Dynamics
- Alzheimer's disease research and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- interferon and immune responses
- Computational Drug Discovery Methods
- Sphingolipid Metabolism and Signaling
- Prion Diseases and Protein Misfolding
- Enzyme Structure and Function
- Skin and Cellular Biology Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Advanced Photocatalysis Techniques
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- TiO2 Photocatalysis and Solar Cells
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related molecular mechanisms research
- Tea Polyphenols and Effects
- Catalytic Processes in Materials Science
- RNA and protein synthesis mechanisms
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Lipid Membrane Structure and Behavior
First Hospital of Jiaxing
2018-2024
Jiaxing University
2018-2024
First Hospital of China Medical University
2024
China Medical University
2024
Vanguard (United States)
2022
University of California, Los Angeles
2008-2012
UCLA Health
2010
Clark University
2004-2008
National High Magnetic Field Laboratory
2006
Florida State University
2006
The pathogenesis of rheumatoid arthritis (RA) is heavily impacted by the inflammation and activation fibroblast-like synoviocytes (FLS). objective this investigation to clarify involvement exosomes derived from FLS stimulated tumour necrosis factor α (TNF-α) in angiogenesis underlying mechanisms. cells were obtained synovial fluid RA patients cell supernatant with TNF-α stimulation ultracentrifugation. Exosomes subsequently analysed using transmission electron microscopy, nanoparticle...
Transthyretin (TTR) is one of the known human amyloidogenic proteins. Its native state a homotetramer with each monomer having beta-sandwich structure. Strong experimental evidence suggests that TTR dissociates into monomeric intermediates and monomers subsequently self-assemble to form amyloid deposits insoluble fibrils. However, details on early steps along pathway formation are unclear, although various approaches resolutions at molecular or residue level have provided some clues. It...
Human transthyretin (TTR) is an amyloidogenic protein whose aggregation associated with several types of amyloid diseases. The following mechanism TTR formation has been proposed. tetramer at first dissociates into native monomers, which the rate-limiting step in fibril formation. monomeric species then partially unfold to form intermediates that subsequently undergo a downhill self-assembly process. deposit can be facilitated by disease-associated point mutations. However, only subtle...
Alzheimer's disease (AD) is linked to the aberrant assembly of amyloid β-protein (Aβ). The 21AEDVGSNKGA30 segment, Aβ(21–30), forms a turn that acts as monomer folding nucleus. Amino acid substitutions within this nucleus cause familial AD. To determine biophysical characteristics nucleus, we studied biologically relevant acetyl-Aβ(21–30)-amide peptide using experimental techniques (limited proteolysis, thermal denaturation, urea denaturation followed by pulse and electron microscopy)...
Rheumatoid arthritis (RA) is the predominant manifestation of inflammatory arthritis, distinguished by an increasing burden morbidity and mortality. The intricate interplay genes signalling pathways involved in synovial inflammation patients with RA remains inadequately comprehended. This study aimed to ascertain role necroptosis RA, as along their associations immune cell infiltration. Differential expression analysis weighted gene co-expression network (WGCNA) were employed identify...
Objective To clarify the role of glucocerebrosidase (GBA) and Ceramide (Cer) in rheumatoid arthritis (RA).Methods GBA-expressing lentivirus were constructed injected into collagen-induced (CIA) mice, compared with CIA mice empty vector. The severity inflammatory mediators evaluated. Fibroblast-like synoviocytes (FLS) from RA patients transfected lentivirus, or pretreated C6-Cer. migration invasion FLS, production cytokines, relevant signaling pathways assessed.Results In GBA markedly...
Objective: This retrospective analysis was to assess the role of Janus kinases (JAK) inhibitors compared with conventional disease modifying anti-rheumatic drugs (DMRADs) in treatment polymyalgia rheumatica (PMR) glucocorticoids (GCs) reduction. Methods: Clinical information collected from PMR patients JAK inhibitor group and DMARDs January 2020 August 2021 at Jiaxing first Hospital. Serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin (Hb), albumin dose GCs...
Objective To investigate the clinical manifestations, laboratory tests, and image modalities on rheumatoid arthritis (RA) accompanied with atlanto-axial joint involvement. Methods Sixty-four cases of RA cervical vertebra involvement were divided into 2 groups by lesion location. Twenty-two involvement, while 42 other than involvement. The age, course, manifestations lab results compared between two t test, Chi-square test Fisher's exact probability. X-ray, CT magnetic resonance...