A5100396658- Colorectal Cancer Surgical Treatments
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Obesity, Physical Activity, Diet
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Nutritional Studies and Diet
- Urologic and reproductive health conditions
- Gastric Cancer Management and Outcomes
- Child Nutrition and Water Access
- Autoimmune and Inflammatory Disorders Research
- Birth, Development, and Health
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Kidney Stones and Urolithiasis Treatments
- NF-κB Signaling Pathways
- Gout, Hyperuricemia, Uric Acid
- Traditional Chinese Medicine Analysis
- Influenza Virus Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Prostate Cancer Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
First Hospital of Jiaxing
2008-2025
Peking University Cancer Hospital
2019-2025
Peking University
2019-2025
Peking University Third Hospital
2024
Poultry Research Institute
2024
Jiaxing University
2020-2023
Bengbu Medical College
2023
Chinese Center For Disease Control and Prevention
2006-2018
Harbin Medical University
2014-2018
Fourth Affiliated Hospital of Harbin Medical University
2018
Debate ensues regarding the stronger indicator of obesity, body mass index (BMI), or waist circumference (WC), in association with hypertension. Furthermore, little research has been done to compare BMI and WC their associations prehypertension. A cross-sectional survey was undertaken 33 communities randomly selected from 3 cities Northeastern China during 2009–2010, using a total 25,196 adults aged 18–74 years an overall response rate 87.4%. Diagnoses prehypertension hypertension were based...
This study focused on the potential therapeutic effect of baicalin collagen-induced arthritis (CIA) in rats and underlying mechanisms. The CIA were injected with (50, 100, or 200 mg/kg) once daily for 30 days. monitored clinical severity arthritis, joint tissues used radiographic assessment histologic examination. We quantified tumor necrosis factor–<i>α</i> (TNF-<i>α</i>) interleukin-1<i>β</i> (IL-1<i>β</i>) experimental animals Western blots to assess levels protein abundance,...
To estimate the energy gap (i.e. degree of positive balance) that is causing weight gain in population China order to provide a quantitative goal for how much behaviour change required prevent excess population. This based on data collected Health and Nutrition Survey. 2288 adults (20-45 years) who took part both 1989 2000 surveys were selected.from 2000, average this increased from 55.4 kg 59.1 kg. The medium increasing rate was 0.33 year(-1). During time, prevalence overweight dramatically...
Background Local advanced rectal cancer (LARC) patients who achieved pathological complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) generally have a favorable prognosis. This retrospective study aimed to evaluate the prognostic value of magnetic resonance imaging (MRI) parameters and neutrophil-to-lymphocyte ratio (NLR) in LARC with pCR. Methods Between 2015 2019, 180 pCR NCRT surgery were included. MRI NLR evaluated as potential predictors for 5-year overall survival (OS)...
Importance Treatment options are needed for patients with rheumatoid arthritis (RA) who experience inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). The efficacy and safety profiles of subcutaneous tocilizumab monotherapy, combined methotrexate, methotrexate alone have not yet been evaluated in the same large-scale study. Objective To evaluate tocilizumab-methotrexate, RA. Design, Setting, Participants This double-blind, phase 3 randomized...
Predicting tumour response would be useful for selecting patients with locally advanced rectal cancer (LARC) organ preservation strategies. We aimed to develop and validate a prediction model T downstaging (ypT0-2) in LARC after neoadjuvant chemoradiotherapy identify those who may benefit from consolidation chemotherapy.cT3-4 at three tertiary medical centers January 2012 2019 were retrospectively included, while prospective cohort was recruited June 2021 March 2022. Eight filter (principal...
The aim of this study was to evaluate disease-activity-guided stepwise tapering or discontinuation rhTNFR:Fc, an etanercept biosimilar, in patients with ankylosing spondylitis (AS) a prospective, randomized, open-label, multicentric study.Active AS disease activity score (ASDAS) ⩾2.1 recruited from 10 hospitals were treated rhTNFR:Fc 50 mg weekly for 12 weeks, and further randomized into different groups according ASDAS at week 12. Patients who achieved clinical remission (ASDAS < 1.3)...
Objective To clarify the role of glucocerebrosidase (GBA) and Ceramide (Cer) in rheumatoid arthritis (RA).Methods GBA-expressing lentivirus were constructed injected into collagen-induced (CIA) mice, compared with CIA mice empty vector. The severity inflammatory mediators evaluated. Fibroblast-like synoviocytes (FLS) from RA patients transfected lentivirus, or pretreated C6-Cer. migration invasion FLS, production cytokines, relevant signaling pathways assessed.Results In GBA markedly...
Objective Previous studies have underlined the genetic susceptibility in pathogenesis of palindromic rheumatism (PR), but known PR loci only partially explain disease's background. We aimed to genetically identify by whole‐exome sequencing (WES). Methods This multicenter prospective study was conducted 10 Chinese specialized rheumatology centers between September 2015 and January 2020. WES performed 185 patients with 272 healthy controls. were divided into subgroups who negative for...
Objectives SLE is a chronic autoimmune disease, which can affect the level of bone metabolism and increase risk osteoporosis fracture. The purpose this research to study effect on turnover markers without influence glucocorticoids. Methods A total 865 female subjects were recruited from Zhejiang Provincial People’s Hospital First Jiaxing, including 391 patients glucocorticoids 474 non-SLE people. We detected Bone amino-terminal propeptide type 1 procollagen (P1NP), C-terminal β - I collagen...