A5100389579- Pancreatic function and diabetes
- Glaucoma and retinal disorders
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Retinal Diseases and Treatments
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Orthopaedic implants and arthroplasty
- Oral microbiology and periodontitis research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hip and Femur Fractures
- Lung Cancer Research Studies
- Lipid metabolism and disorders
- Retinal Imaging and Analysis
- Vitamin D Research Studies
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Corneal surgery and disorders
- Bone fractures and treatments
- Pregnancy and preeclampsia studies
- Bone health and osteoporosis research
Seoul Veterans Hospital
2018-2025
Chung-Ang University
2022-2024
Brown University
2021-2023
Soonchunhyang University Hospital
2022
Weatherford College
2022
The University of Texas Southwestern Medical Center
2000-2021
VA North Texas Health Care System
2018-2021
National Taiwan University
2021
Seoul National University
2016-2019
Boramae Medical Center
2019
In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined low-dose insulin reverses the catabolic state through suppression of hyperglucagonemia. Additionally, it mimics anabolic actions monotherapy and normalizes hemoglobin A1c far less glucose variability. We show that therapy, like insulin, levels a wide array hepatic intermediary metabolites in multiple chemical classes, including acylcarnitines, organic acids (tricarboxylic acid cycle intermediates),...
OBJECTIVE To determine the role of glucagon action in metabolic phenotype untreated insulin deficiency. RESEARCH DESIGN AND METHODS We compared pertinent clinical and parameters receptor-null (Gcgr−/−) mice wild-type (Gcgr+/+) controls after equivalent destruction β-cells. used a double dose streptozotocin to maximize β-cell destruction. RESULTS Gcgr+/+ became hyperglycemic (>500 mg/dL), hyperketonemic, polyuric, cachectic had be killed 6 weeks. Despite comparable Gcgr−/− mice, none...
To test the hypothesis that physiologic liporegulatory role of hyperleptinemia is to prevent steatosis during caloric excess, we induced obesity by feeding normal Harlan Sprague-Dawley rats a 60% fat diet. Hyperleptinemia began within 24 h and increased progressively 26 ng/ml after 10 weeks, correlating with an ∼150-fold increase in body (r = 0.91, p < 0.0001). During this time, triacylglycerol (TG) content nonadipose tissues rose only 1–2.7-fold implying antisteatotic activity. In rodents...
The thiazolidinedione compound troglitazone, which is used to treat non-insulin-dependent diabetes mellitus (NIDDM) in man, also effective the adipogenic NIDDM of Zucker diabetic fatty (ZDF) rats. To test "lipotoxicity hypothesis," attributes beta cell dysfunction an excessive accumulation fat pancreatic islets, we sought determine if troglitazone-mediated amelioration function islets ZDF rats might be associated with a reduction their elevated triglyceride (TG) content. Troglitazone (10 μm)...
To determine unambiguously if suppression of glucagon action will eliminate manifestations diabetes, we expressed receptors in livers receptor-null (GcgR(-/-)) mice before and after β-cell destruction by high-dose streptozotocin. Wild type (WT) developed fatal diabetic ketoacidosis streptozotocin, whereas GcgR(-/-) with similar remained clinically normal without hyperglycemia, impaired glucose tolerance, or hepatic glycogen depletion. Restoration receptor expression using adenovirus...
Insulin monotherapy can neither maintain normoglycemia in type 1 diabetes (T1D) nor prevent the long-term damage indicated by elevated glycation products blood, such as glycated hemoglobin (HbA1c). Here we find that hyperglycemia, when unaccompanied an acute increase insulin, enhances itself paradoxically stimulating hyperglucagonemia. Raising glucose from 5 to 25 mM without insulin enhanced glucagon secretion ∼two- fivefold InR1-G9 α cells and ∼18-fold perfused pancreata insulin-deficient...
The onset of NIDDM in obese Zucker diabetic fatty (fa/fa) rats is preceded by a striking increase the plasma levels free acids (FFAs) and sixfold rise triglyceride content pancreatic islets. latter finding provides clear evidence elevated tissue long-chain acyl CoA, which can impair β-cell cell function. To determine if accumulation entirely passive consequence high FFA or prediabetic islets have an increased lipogenic capacity that might predispose to NIDDM, metabolism was compared...
Expression of peroxisome proliferator-activated receptor α (PPARα) and enzymes fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets obese, prediabetic Zucker diabetic ( fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARα/retinoid x ligands, FA all up-regulate PPARα stimulate [ 3 H]-palmitate normal but not from fa/fa rats. Overexpression OB-R corrects foregoing abnormalities reverses phenotype. a OB-R-dependent factor required for fat homeostasis...
Significance Diet-induced type 2 diabetes (T2D) is becoming a worldwide epidemic. Patients with T2D fail to respond insulin normally and have elevated blood glucose insulin. In autoimmune diabetes, due uncontrolled glucagon, hormone suppressed opposed by To study the role of glucagon in T2D, rodent models disease were created lacking action. These animals failed develop hyperglycemia unless action was restored or given high concentrations typical T2D. This indicates that unopposed necessary...
The Health and Prevention Enhancement (H-PEACE) study was designed to investigate the association of diagnostic imaging results, biomarkers predisease stage non-communicable diseases (NCDs), such as malignancies metabolic diseases, in an average-risk population Korea.This enrolled a large-scale retrospective cohort at Healthcare System Gangnam Center, Seoul National University Hospital, from October 2003 December 2014.The baseline follow-up information collected NCDs allows for evaluation...
Abstract Background Adequate physical activity (PA) is essential for preventing sarcopenia in older adults. However, there are insufficient epidemiological data on the intensity of PA needed to prevent age-related sarcopenia. The purpose this study was investigate association with skeletal muscle mass and strength. Methods This a population-based cross-sectional design that conducted using from 2008 − 2011 2014 2018 Korea National Health Nutrition Examination Surveys, which included total...
Abstract Genome-wide association studies have identified several genetic variants associated with nonalcoholic fatty liver disease. To emphasize metabolic abnormalities in liver, (dysfunction)-associated disease (MAFLD) has been introduced; thus, we aimed to investigate single-nucleotide polymorphisms related MAFLD and its subtypes. A genome-wide study was performed identify factors MAFLD. We used a Korean population-based sample of 2282 subjects control group 4669. replicated the results...
The development of nonalcoholic fatty liver disease (NAFLD) is associated with multiple genetic and environmental factors.We performed a genome-wide association study to identify the factors related NAFLD in Korean population-based sample 1,593 subjects 2,816 controls. We replicated data another that included 744 patients 1,137 investigated single-nucleotide polymorphisms (SNPs) were NAFLD.After adjusting for age, sex body mass index, rs738409, rs12483959 rs2281135, located PNPLA3 gene,...
The antidiabetic potential of glucagon receptor antagonism presents an opportunity for use in insulin-centric clinical environment. To investigate the metabolic effects type 2 diabetes, we treated Leprdb/db and Lepob/ob mice with REMD 2.59, a human monoclonal antibody competitive antagonist receptor. As expected, 2.59 suppresses hepatic glucose production improves glycemia. Surprisingly, it also enhances insulin action both liver skeletal muscle, coinciding increase AMP-activated protein...
Significance Both type 1 and 2 diabetes are associated with reduced β-cell mass or function, resulting from decreased proliferation increased apoptosis. Understanding the signals governing survival regeneration is critical for developing strategies to maintain healthy populations of these cells in individuals. forms hyperglucagonemia an plasma glucagon:insulin ratio. Glucagon excess contributes metabolic dysregulation diabetic state glucagon receptor antagonism a potential target area...
Abstract Sarcopenia is an age-related disorder characterised by a progressive decrease in skeletal muscle mass. As the genetic biomarkers for sarcopenia are not yet well characterised, this study aimed to investigate variations related relatively aged cohort, using genome-wide association (GWAS) meta-analyses of lean body mass (LBM) 6961 subjects. Two Korean cohorts were analysed, and subgroup GWAS was conducted appendicular (ASM) index. The effects significant single nucleotide...
Researchers have proposed a possible correlation between age-related macular degeneration (AMD) and inflammation or C-reactive protein (CRP) levels. We investigated the potential causal relationship CRP levels AMD. Single-nucleotide polymorphisms (SNPs) associated with exposure were selected as instrumental variables (IVs) significance (p < 5 × 10−8) from genome-wide association study (GWAS) meta-analysis data of Biobank Japan UK Biobank. GWAS for AMD obtained 11 International Genomics...
Chronic kidney disease (CKD) is an important social health problem characterized by a decrease in the glomerular filtration rate (GFR). In this study, we analyzed genome-wide association studies for disease-related traits using data from Korean adult screening cohort comprising 7,064 participants. Kidney include blood urea nitrogen (BUN), serum creatinine, estimated GFR, and uric acid levels. We detected two genetic loci (SLC14A2 intergenic region) 8 single nucleotide polymorphisms (SNPs)...
This study investigated whether filtering blebs can be evaluated using optical coherence tomography angiography (OCT-A) and compared vascularity parameters with conventional bleb grading systems.A total of 92 patients glaucoma, who underwent mitomycin C-augmented trabeculectomy, were enrolled in this study, eyes assessed total. The participants OCT-A external mode anterior segment photography for evaluation. For evaluation vascularity, a blinded observer carefully drew the area on original...
Abstract Objectives This study investigated fracture rates and risk indicators for fractures in internal connection dental implants. Material Methods We performed a retrospective analysis of 19,006 implants used fixed restoration 5,124 patients (4,570 males, 554 females) at the Dental Hospital Veterans Health Service Medical Center between 2006 2015. Patients were followed through June 2018 (0.03–12.39 years post‐installation). Clinical factors (age, sex, implant diameter, length, placement...
Abstract Background Sarcopenia is characterized by a progressive decrease in skeletal muscle mass and function with age. Given that sarcopenia associated various metabolic disorders, effective biomarkers for its early detection are required. We aimed to investigate the related elderly men perform experimental studies using metabolomics. Methods Plasma metabolites from 142 men, comprising group an age‐matched control group, were measured global metabolome profiling. Muscle plasma samples...
Researchers have suggested a potential relationship between gamma-glutamyl transferase (GGT) level and stroke. We investigated causal GGT as exposures stroke subtypes (cardioembolic, small vessel, large artery) in European population. performed two-sample Mendelian randomization (MR) study using the genome-wide association (GWAS) data from UK Biobank exposure set. For outcome set, we used GWAS GIGASTROKE Consortium. considered alcohol consumption, atrial fibrillation, body mass index...
Background/Objectives: Individuals with metabolic syndrome (MetS) present reduced 25(OH)D levels. We performed a two-sample Mendelian randomization (MR) study to investigate whether causal relationships exist between levels and MetS/MetS risk traits, including waist circumference, body mass index (BMI), hypertension (systolic/diastolic blood pressure), triglyceride, high-density lipoprotein cholesterol, glucose Methods: employed genetic variants related from the SUNLIGHT Consortium European...