A5034951202- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Folate and B Vitamins Research
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Lipid metabolism and disorders
- Cardiovascular Function and Risk Factors
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Pancreatitis Pathology and Treatment
- Physical Activity and Health
- Gallbladder and Bile Duct Disorders
- Obesity, Physical Activity, Diet
- Colorectal Cancer Surgical Treatments
- Statistical Methods and Bayesian Inference
- Helicobacter pylori-related gastroenterology studies
Seoul National University Hospital
2016-2025
Seoul National University
2009-2021
Soongsil University
2021
Catholic University of Korea
2021
General Electric (Spain)
2013
National University College
2013
New Generation University College
2013
Samsung Medical Center
2004-2012
Sungkyunkwan University
2012
Background and Aims: A new term, metabolic dysfunction–associated steatotic liver disease (MASLD), has been proposed by a multi-society expert panel. However, it remains unclear whether hepatic steatosis per se in MASLD contributes to an increased risk of mortality individuals with any cardio-metabolic factor (CMRF), which is also significant for mortality. This study aimed compare all-cause cause-specific between the “MASLD/MetALD” “no (SLD)” groups CMRF. Approach Results: population-based...
Abstract Background and Objectives Artificial intelligence is increasingly being employed in healthcare, raising concerns about the exacerbation of disparities. This study evaluates ChatGPT GPT-4’s ability to comprehend respond cirrhosis-related questions English, Korean, Mandarin, Spanish, addressing language barriers that may impact patient care. Methods A set 36 were translated into Spanish prompted both GPT-4 models. Non-English responses graded by native-speaking hepatologists on...
AIM:To investigate the relationship between gallstone disease and nonalcoholic fatty liver (NAFLD) in a large Asian population. METHODS:A cross-sectional study including 17612 subjects recruited from general health check-ups at Seoul National University Hospital, Healthcare System Gangnam Center January 2010 December was conducted.NAFLD were diagnosed based on typical ultrasonographic findings.Subjects who positive for hepatitis B or C, had history of heavy alcohol consumption (> 30 g/d men...
The Health and Prevention Enhancement (H-PEACE) study was designed to investigate the association of diagnostic imaging results, biomarkers predisease stage non-communicable diseases (NCDs), such as malignancies metabolic diseases, in an average-risk population Korea.This enrolled a large-scale retrospective cohort at Healthcare System Gangnam Center, Seoul National University Hospital, from October 2003 December 2014.The baseline follow-up information collected NCDs allows for evaluation...
The development of nonalcoholic fatty liver disease (NAFLD) is associated with multiple genetic and environmental factors.We performed a genome-wide association study to identify the factors related NAFLD in Korean population-based sample 1,593 subjects 2,816 controls. We replicated data another that included 744 patients 1,137 investigated single-nucleotide polymorphisms (SNPs) were NAFLD.After adjusting for age, sex body mass index, rs738409, rs12483959 rs2281135, located PNPLA3 gene,...
Background/Aims: A low vitamin D level has been associated with metabolic syndrome and diabetes. However, an association between a nonalcoholic fatty liver disease (NAFLD) not yet definitively established. This study aimed to characterize the relationship NAFLD in Korea. Methods: cross-sectional involving 6,055 health check-up subjects was conducted. diagnosed on basis of typical ultrasonographic findings history alcohol consumption. Results: The were aged 51.7±10.3 years (mean±SD) 54.7%...
Nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery calcification (CAC) in cross-sectional studies. However, whether NAFLD itself affects CAC development or progression remains unknown.This study investigated the longitudinal association between and score.This a cohort performed healthcare center.Among 1732 subjects who underwent serial evaluation, we evaluated 846 886 without NAFLD, as diagnosed via ultrasonography.CAC score was compared at baseline follow-up. In...
Limited evidence supports a role for physical activity (PA) in nonalcoholic fatty liver disease (NAFLD) independent of visceral obesity or/and insulin resistance. We investigated the association between PA and NAFLD while considering adipose tissue (VAT) resistance large general population.Nonalcoholic was diagnosed based on typical ultrasonographic findings. A detailed questionnaire included type, frequency, duration length time that subject engaged PA. determined by metabolic equivalent....
Nonalcoholic fatty liver disease (NAFLD) is increasing worldwide, highlighting the importance of early and accurate detection appropriate management NAFLD. However, ultrasonography (US) not included in many mass screening programs, people have limited access to it. The aim this study validate index (FLI) investigate optimal cutoff value for predicting NAFLD an asymptomatic population. We conducted a retrospective cohort Korea. All subjects who underwent health checkup exams, including...
Metabolic (dysfunction)-associated fatty liver disease (MAFLD) emphasizes the metabolic dysfunction in nonalcoholic (NAFLD). Although relationship between low muscle mass and NAFLD has been suggested, effect of MAFLD on is yet to be investigated. In this study, we examined an asymptomatic Korean population.Examinees who underwent FibroScan® bioelectrical impedance analyses same day during period June 2017 December 2019 were included. Hepatic steatosis was diagnosed using controlled...
Background/Aims . Women after menopause have increased insulin resistance and visceral fat, which may increase the prevalence of nonalcoholic fatty liver disease (NAFLD). However, pathogenesis NAFLD in women has not been clearly defined. In this study, we aimed to determine risk factors for women. Methods A retrospective cohort study was conducted. who underwent abdominal ultrasonography blood sampling routine health check-ups were recruited. Results Among 1,423 subjects, 695 (48.9%) a...
Physical activity (PA) is inversely associated with nonalcoholic fatty liver disease (NAFLD) prevalence. However, few studies evaluated the effect of PA on NAFLD incidence in regard to visceral adipose tissue (VAT) and insulin resistance (IR). We investigated whether at baseline change during follow-up have any incident NAFLD.We enrolled subjects who underwent health screenings between 2007 2008 participated voluntary 2011 2013 (median 4.42 years). Incident was defined as absence presence by...
Chronic systemic inflammation is an important causative factor in the pathogenesis of atherosclerosis. However, effect chronic Helicobacter pylori (Hp) infection on arterial stiffness, a predictor cardiovascular events, remains unclear. We evaluated association between Hp and stiffness asymptomatic healthy individuals.Arterial was using cardio-ankle vascular index (CAVI). included subjects who underwent CAVI anti-Hp IgG antibody evaluations, simultaneously, March 2013 July 2017. Demographic...
The incidence of cancer and its associated mortality have increased over the past several decades [...]
Nonalcoholic fatty liver disease (NAFLD) is associated with risk factors for cardiovascular disease. The cardioankle vascular index (CAVI), a new measure of arterial stiffness, was recently developed and independent blood pressure. We investigated whether NAFLD stiffness as measured using the CAVI in an apparently healthy population. A total 2954 subjects without any known diseases were enrolled. diagnosed via typical ultrasonography. clinical characteristics examined included age, sex, body...