Background Infertility has been confirmed as a significant medical and social problem. Heavy metal exposure refers to risk factor for infertility, which is capable of damaging the reproductive system males females. However, heavy female infertility have rarely investigated. The aim this study was analyze association between infertility. Methods A cross-sectional using data from three cycles National Health Nutrition Examination Survey (NHANES, 2013–2018) performed. Female evaluated by...

Metabolism dysfunction can affect the biological behavior of tumor cells and result in carcinogenesis development various cancers. However, few thoughtful studies focus on predictive value efficacy immunotherapy metabolism-related gene signatures endometrial cancer (EC). This research aims to construct a signature EC with prognostic therapeutic implications.We downloaded RNA profile clinical data 503 patients screened out different expressions genes prognosis influence from The Cancer Genome...

A multicomponent DNA vaccine, encoding Toxoplasma gondii GRA1 and SAG1, was constructed tested for its ability to confer protection. BALB/c mice were challenged with tachyzoites of the virulent T. RH strain at 4 weeks following last immunization, immune responses survival times observed. The results show that vaccination by vaccine prolonged (from average 4.50 ± 0.22 7.60 0.74 days); induced high levels IgG antibody 0.252 0.080 0.790 0.083), IFN-gamma 598.74 67.50 853.77 66.74 pg/ml), IL-2...

Abstract Aims To present a case series of 11 rare uterine tumors resembling ovarian sex cord (UTROSCTs), and review the literature on this topic to offer up-to-date treatment management for UTROSCTs. Method Eight cases from Fujian Cancer Hospital between January 2017 May 2023 three patients Union October 2012 2020 were retrospectively reviewed. All pathologically confirmed as UTROSCTs by two senior experienced pathologists. Clinical behaviors, medical data, histopathological features,...

Abstract Backgrounds Platelet‐to‐albumin ratio (PAR) is a new systemic inflammatory prognostic indicator associated with many diseases. However, its role in radiation cystitis (RC) obscure. This study aimed to explore whether PAR could be used as an effective parameter for predicting the RC risk local advanced cervical cancer (CC) treated radiotherapy. Methods A total of 319 CC patients who received radical radiotherapy at Fujian Cancer Hospital were enrolled between December 2018 and...

This retrospective study aimed to stress the advantages of autologous hematopoietic stem cell transplantation (auto-HSCT) in treating primary MM. Ninety-four MM patients who underwent initial parallel sequential auto-HSCT were selected. Data on efficacy (efficacy evaluation, renal function and hemoglobin recovery), immune reconstitution (B-cell subsets, immunoglobulin levels, T-cell NK cells, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR)) times collected analyzed....

Pancreatic ductal adenocarcinoma (PDAC) has a heterogeneous make-up of myeloid cells that influences the therapeutic response and prognosis. However, understanding cell at both genetic cellular level remains significant challenge. Single-cell RNA sequencing (scRNA-seq) data were downloaded from t Tumor Immune Hub gene expression retrieved The Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO) database. set variation analysis (GSVA) was used to estimate relative proportions...

Neuroendocrine carcinoma of the cervix (NECC) is a rare and highly aggressive subtype cervical carcinomas with poor prognosis. NECC tends to occur in young age which could severely impair mental physical health patients. Therefore, this study aims develop an individualized prognostic nomogram for 360 (≤45 years old) patients were retrospectively selected from Surveillance, Epidemiology End Results (SEER) database randomly located training cohort internal validation ratio 7:3. Data Fujian...

Purpose: Elastic dental implant crown material may be able to reduce the impact force that is transmitted and surrounding alveolar bone during occlusal process. This study aims compare displacement values of implant-supported single crowns with different materials abutment designs. The hypothesis (T0) this was designs have no effect on restorations. Methods: Crowns were fabricated from three materials: Aidite zirconia, Vita Enamic resin-matrix ceramics, breCAM PEEK. These paired custom...

Ileum adenocarcinoma (IA), a type of small bowel adenocarcinoma, is rather uncommon factor associated with obstruction in bowel. Owing to its location and indefinite clinical symptoms, the diagnosis IA difficult, survival usually poor. With respect rarity this disease, very few studies have reported such cases provide reference for treatment. In manuscript, case 48-year-old man presented chronic right lower abdominal pain distention, queasiness emesis. A computed tomography scan revealed...

Introduction Recently, immunotherapy has significantly transformed the treatment landscape of endometrial cancer (EC). Results from KEYNOTE-158, RUBY and AtTEnd showed programmed cell death 1 (PD-1) or death-ligand inhibitors with promising efficacy in primary advanced recurrent EC. However, few studies focused on role dual immune checkpoints Cadonilimab is an checkpoint inhibitor targeting PD-1 T-lymphocyte antigen-4, which expected to show substantial clinical Combining cadonilimab...

Abstract Background The purposes of this simulation study were to evaluate the stresses in roots endodontically treated molars with extensive coronal tissue loss which restored by endocrowns (all-in-one core and crown) traditional crowns post-cores, during masticatory using finite element analysis. Methods A mesio-distal cross-section a lower right first molar was digitized used create 2-dimensional models teeth supporting tissue; different crown designs, viz ., endocrown 2 mm occlusal...

Platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has been proposed as an alternative treatment approach for cervical cancer (CC) in stage Ib2-IIb, who had a strong desire to be treated with surgery. Our study aims develop model based on multimodal MRI using radiomics and deep learning predict the response CC patients chemoradiotherapy (NACRT). From August 2009 June 2013, Ib2-IIb (FIGO 2008) received NACRT at Fujian Cancer Hospital were enrolled our study....

To analyze the survival outcomes of female patients with cervical, uterine, and ovarian cancers in Southeast China (Fujian Province) from 2011 to 2020 provide a reference basis for prognostic evaluation prevention gynecological malignancies.

Abstract Background Understanding the pathogenesis of influenza infection is a key factor leading to prevention and control future outbreaks. Pandemic 2009 Influenza H1N1 infection, although frequently mild, led severe fatal form disease in certain cases that make its virulence nature debatable. Much effort has been made toward explaining determinants severity; however, no absolute reason established. Results This study presents heterogeneous clinically similar strains pandemic virus human...

Lung cancer is the most commonly diagnosed and leading cause of cancer-related deaths in China. Rapid precise evaluation tumor tissue during lung surgery can reduce operative time improve negative-margin assessment, thus increasing disease-free overall survival rates. This study aimed to explore potential label-free multiphoton microscopy (MPM) for imaging adenocarcinoma tissues, detecting histopathological features, distinguishing between normal cancerous tissues. We showed that second...

Organ preservation is now considered an acceptable alternative option in distal rectal cancer patients with clinical complete response (cCR) after neoadjuvant chemoradiation (CRT). But the cCR rate low and about one-third of tumour will regrow, which requires more effective local treatment. CRT combined intra-arterial chemotherapy (IAC) might be a promising approach. Additionally, total therapy using FOLFIRINOX induction improved survival while consolidation organ preservation. We assess...

Customized posts-and-cores have been widely used for improved fitness within a prepared post space. However, in comparison to direct restoration, they necessitate an increased number of appointments patients. A 24-year-old man presented with maxillary left canine that had fractured due trauma 10 months previously. For this case, digital process was simultaneous restoration personalized titanium post-and-core and zirconia crown achieved intraoral scanner (IOS) computer-aided...

Abstract Object This study aimed to establish an effective risk nomogram predict the early distant metastasis (EDM) probability of cervical cancer (CC) patients treated with radical radiotherapy aid individualized clinical decision‐making. Methods A total 489 biopsy‐confirmed CC between December 2018 and January 2021 were enrolled. Logistic regression stepwise backward method was used identify independent factors. The efficacy evaluated by using area under receiver operating characteristic...