A5033114100- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cutaneous lymphoproliferative disorders research
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Histiocytic Disorders and Treatments
- T-cell and Retrovirus Studies
- Tumors and Oncological Cases
- Protein Degradation and Inhibitors
- Bone Tumor Diagnosis and Treatments
- Cancer-related gene regulation
- Polyomavirus and related diseases
- Gastrointestinal Tumor Research and Treatment
Fred Hutch Cancer Center
2021-2025
University of Washington
2021-2025
Seattle University
2023-2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2022-2024
Cancer Research Center
2024
Imperial College Healthcare NHS Trust
2014-2023
PSG INSTITUTE OF TECHNOLOGY AND APPLIED RESEARCH
2023
Imperial College London
2013-2022
Hammersmith Hospital
2013-2022
Cancer Research UK
2021-2022
SummaryBackgroundSevere COVID-19 has a high mortality rate. Comprehensive pathological descriptions of are scarce and limited in scope. We aimed to describe the histopathological findings viral tropism patients who died severe COVID-19.MethodsIn this case series, were considered eligible if they older than 18 years, with premortem diagnosis acute respiratory syndrome coronavirus 2 infection listed clinically as direct cause death. Between March 1 April 30, 2020, full post-mortem examinations...
Diffuse large B-cell lymphoma (DLBCL) is the most common form of in adults. The disease exhibits a striking heterogeneity gene expression profiles and clinical outcomes, but its genetic causes remain to be fully defined. Through whole genome exome sequencing, we characterized diversity DLBCL. In all, sequenced 73 DLBCL primary tumors (34 with matched normal DNA). Separately, exomes 21 cell lines. We identified 322 cancer genes that were recurrently mutated DLBCLs. recurrent mutations...
Combined modality treatment using multidrug chemotherapy (CTh) and radiotherapy (RT) is currently considered the standard of care in early stage Hodgkin's disease. Its role advanced stages, however, continues to be debated. This study was aimed at evaluating consolidation radiation patients achieving a complete remission after six cycles doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) event-free survival (EFS) overall (OS) as primary end points.Two hundred fifty-one with disease...
To describe clinical features, treatment outcomes and relapse rates in HIV-associated multicentric Castleman's disease (MCD) a sizeable mature cohort.From prospective database, we identified 61 HIV-seropositive patients with histologically confirmed MCD (median follow-up, 4.2 years). Since 2003, 49 newly diagnosed have been treated rituximab (n = 14) or without 35) etoposide.At diagnosis, 55 (90%) of met proposed criteria defining an attack. Four (7%) had histologic evidence coexisting...
Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined genetic landscape EATL through whole-exome sequencing 69 tumors. SETD2 was frequently silenced gene in (32% cases). The JAK-STAT pathway mutated pathway, with frequent mutations STAT5B as well JAK1, JAK3, STAT3, SOCS1. We also identified KRAS, TP53, TERT. Type I type II (monomorphic epitheliotropic intestinal lymphoma) had highly overlapping alterations...
Background Cyclin D1-positive B cells are occasionally found in the mantle zones of reactive lymphoid follicles, a condition that has been called "in situ cell lymphoma". The clinical significance this lesion remains uncertain.Design and Methods pathological characteristics, including SOX11 expression, 23 cases initially diagnosed as lymphoma were studied.Results Seventeen fulfilled criteria for lymphoma. In most cases, lesions incidental findings lymph nodes. t(11;14) was detected all eight...
Epstein-Barr virus (EBV) persistently infects more than 90% of the human population and is etiologically linked to several B cell malignancies, including Burkitt lymphoma (BL), Hodgkin (HL), diffuse large (DLBCL). Despite its growth transforming properties, most immune-competent individuals control EBV infection throughout their lives. encodes various oncogenes, 6 latency-associated EBV-encoded nuclear antigens, only EBNA3B completely dispensable for transformation in vitro. Here, we report...
Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19+ B lymphomas are often short lived. We tested whether CAR19-engineering of the CD1d-restricted invariant natural killer T (iNKT) cells would result enhanced anti-lymphoma activity. CAR19-iNKT co-operatively activated by CD1d- and CAR19-CD19-dependent interactions more effective than CAR19-T against CD1d-expressing vitro vivo. The swifter vivo activity their ability to eradicate brain...
Abstract The fifth edition of the World Health Organization Classification Haematolymphoid Tumours (WHO‐HAEM5) is product an evidence‐based evolution revised fourth with wide multidisciplinary consultation. Nonetheless, while every classification incorporates scientific advances and aims to improve upon prior version, medical knowledge remains incomplete individual neoplasms may not be easily subclassified in a given scheme. Thus, optimal requires ongoing study, there are certain aspects...
Posttransplant lymphoproliferative disorders (PTLDs) are a group of diseases that range from benign polyclonal to malignant monoclonal lymphoid proliferations. They arise secondary treatment with immunosuppressive drugs given prevent transplant rejection. Three main pathologic subsets/stages evolution recognised: early, polymorphic, and monomorphic lesions. The pathogenesis PTLDs seems be multifactorial. Among possible infective aetiologies, the role EBV has been studied in depth, virus is...