Ιoannis Kotsianidis
A5016064577- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immune cells in cancer
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Hematological disorders and diagnostics
- Histone Deacetylase Inhibitors Research
- Pneumocystis jirovecii pneumonia detection and treatment
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Bone and Joint Diseases
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
Democritus University of Thrace
2016-2025
University Hospital of Alexandroupolis
2016-2025
Trakia University
2022-2023
Hellenic Oncology Research Group
2016-2020
Assistance Publique – Hôpitaux de Paris
2017
Inserm
2017
Centre Hospitalier Universitaire Henri-Mondor
2017
Université d'Angers
2017
Université Paris Nanterre
2017
Université Paris-Est Créteil
2017
BACKGROUND: Risk stratification and therapeutic decision-making for myelodysplastic syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), which considers hematologic parameters cytogenetic abnormalities. Somatic gene mutations not yet used in risk of patients with MDS. METHODS: To develop a clinical-molecular prognostic model (IPSS-Molecular [IPSS-M]), pretreatment diagnostic or peridiagnostic samples from 2957 MDS were profiled 152 genes. Clinical...
Probiotic microorganisms such as lactic acid bacteria (LAB) exert a number of strain-specific health-promoting activities attributed to their immunomodulatory, anti-inflammatory and anti-carcinogenic properties. Despite recent attention, our understanding the biological processes involved in beneficial effects LAB strains is still limited. To this end, present study investigated growth-inhibitory Lactobacillus casei ATCC 393 against experimental colon cancer. Administration live (as well...
The implication of T cells in the pathogenesis idiopathic pulmonary fibrosis (IPF) is controversial. CD4(+)CD25(+)FOXP3(+) regulatory (Tregs) are pivotal maintaining immune homeostasis, but their role IPF pathophysiology has not yet been studied.To explore Treg dynamics and function IPF.Treg levels were analyzed by flow cytometry peripheral blood (PB) bronchoalveolar lavage (BAL) 21 patients with IPF, 35 lung diseases other than (patients without IPF), 20 collagen vascular parenchymal...
Background Sepsis is associated with systemic inflammatory responses and induction of coagulation system. Neutrophil extracellular traps (NETs) constitute an antimicrobial mechanism, recently implicated in thrombosis via platelet entrapment aggregation. Methodology/Principal Findings In this study, we demonstrate for the first time localization thrombogenic tissue factor (TF) NETs released by neutrophils derived from patients gram-negative sepsis normal treated either serum septic or...
study objectives: Several lines of evidence suggest immune system derangement in obstructive sleep apnea syndrome (OSAS) patients.However, no data exist on the long-term effect continuous positive airway pressure (CPAP) treatment systemic immunity.Hence, we sought to evaluate this various immunological parameters OSAS patients.design: Prospective case series.setting: Sleep unit a general hospital.Patients: Newly-diagnosed, nonsmoking, otherwise healthy male patients (n = 52) were evaluated...
Background The role of neutrophils in tumour biology is largely unresolved. Recently, independent studies indicated either neutrophil extracellular traps (NETs) or Tissue Factor (TF) involvement cancer and associated thrombosis. However, their individual combined colonic adenocarcinoma still unexplored. Methods Colectomy tissue specimens variable number draining lymph nodes were obtained from ten patients with the colon. NETs deposition presence as well TF expression examined by...
The role of dietary probiotic strains on host anti-cancer immune responses against experimental colon carcinoma was investigated. We have previously shown that Lactobacillus casei administration led to tumor growth suppression in an cancer model. Here, we investigated the underlying mechanisms involved this tumor-growth inhibitory effect. BALB/c mice received daily live lactobacilli per os prior establishment a syngeneic subcutaneous CT26 tumor. Tumor volume, cytokine production, T cell...
SummaryBackgroundIn our previous study on erythropoiesis-stimulating agent (ESA) treatment in lower risk myelodysplastic syndromes from the European MDS (EUMDS) Registry, we showed that patients treated with ESAs had longer survival compared who receive red blood cell transfusion (RBCT). In this study, a follow up time and more included, aimed to assess long-term effects health-related quality of life (HRQoL) exposure or without RBCT syndromes.MethodsThe EUMDS Registry is non-interventional,...
Purpose Most anemic patients with non-deleted 5q lower-risk myelodysplastic syndromes (MDS) are treated erythropoiesis-stimulating agents (ESAs), a response rate of approximately 50%. Second-line treatments, including hypomethylating (HMAs), lenalidomide (LEN), and investigational drugs, may be used after ESA failure in some countries, but their effect on disease progression overall survival (OS) is unknown. Here, we analyzed outcome the second-line treatments. Patients Methods We examined...
Generalized pustular psoriasis (GPP) is a severe type of accompanied by systemic and often life-threatening manifestations. The efficacy the interleukin (IL)-1 antagonist anakinra in cases GPP underscores role IL-1 disease pathogenesis. We present case middle-aged man who developed an abrupt form with eosinophilia cholestatic hepatitis. patient received salvage treatment combination glucocorticoids, hydroxyurea imatinib, while administration inhibitor resulted remission hepatitis significant...
Idiopathic pulmonary fibrosis represents a lethal form of progressive fibrotic lung disorder with gradually increasing incidence worldwide. Despite intense research efforts its pathogenesis is still elusive and controversial reflecting in the current disappointing status regarding treatment.We report first protocol proposal prospective, unicentric, non-randomized, phase Ib clinical trial to study safety tolerability adipose-derived stem cells (ADSCs) stromal vascular fraction (SVF) as...
It has been shown that bone marrow mesenchymal stromal cells (MSCs) from patients with myelodysplastic syndromes (MDSs) display defective proliferative potential. We have probed the impaired replicative capacity of culture-expanded MSCs in MDS (n=30) compared healthy subjects (n=32) by studying senescence characteristics and gene expression associated WNT/transforming growth factor-β1 (TGFB1) signaling pathways. also explored consequences patient MSC potential investigating their...
Immune regulation is a finely balanced process of positive and negative signals. PD-L1 its receptor PD-1 are critical regulators autoimmune, antiviral antitumoural T cell responses. Although the function predominant membrane-bound form well established, source biological activity soluble (sPD-L1) remain incompletely understood. Here, we show that sPD-L1 in human healthy tissues tumours produced by exaptation an intronic LINE-2A (L2A) endogenous retroelement CD274 gene, encoding PD-L1, which...
Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain, isolated recently from feta-type cheese. Its probiotic potential has been demonstrated in series of established vitro tests. Moreover, incorporation L. as starter culture offered organoleptic and technological advantages to novel fermented food products. In the present study, further investigation activity was performed its mechanisms action were investigated. Employing quantitative analysis confocal, fluorescent microscopy...
Progression-free survival (PFS) of patients with lower-risk myelodysplastic syndromes (MDS) treated red blood cell transfusions is usually reduced, but it unclear whether transfusion dose density an independent prognostic factor. The European MDS Registry collects prospective data at 6-monthly intervals from newly diagnosed in 16 countries and Israel. Data on the - cumulative received end each interval divided by time since beginning which first was were analyzed using proportional hazards...
Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, impact CLL-related factors and CLL-directed treatment is still unclear represents focus this work. We conducted retrospective international multicenter study assess incidence OMs detect potential in 19,705 patients CLL, small lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 2016. Data collection took...