A5049198604- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Bone and Joint Diseases
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
- Cancer therapeutics and mechanisms
- Iron Metabolism and Disorders
- Neutropenia and Cancer Infections
- CNS Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Microtubule and mitosis dynamics
- Viral-associated cancers and disorders
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Chemotherapy-related skin toxicity
Universidade Federal do Ceará
2016-2025
Columbia University Irving Medical Center
2016-2023
Associação Paulista para o Desenvolvimento da Medicina
2023
Hospital Universitário Walter Cantídio
2009-2022
Universidade Federal de São Paulo
2002-2016
Faculdade de Ciências Médicas de Minas Gerais
2012
Hospital Haroldo Juaçaba
2009
Associação Paulista de Medicina
2008
Fundação de Apoio à Universidade Federal de São Paulo
2006
Hospital Santa Paula
2004
BACKGROUND: Risk stratification and therapeutic decision-making for myelodysplastic syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), which considers hematologic parameters cytogenetic abnormalities. Somatic gene mutations not yet used in risk of patients with MDS. METHODS: To develop a clinical-molecular prognostic model (IPSS-Molecular [IPSS-M]), pretreatment diagnostic or peridiagnostic samples from 2957 MDS were profiled 152 genes. Clinical...
Severe diarrhoea, a common gastrointestinal manifestation of anticancer treatment with irinotecan, might involve single nucleotide polymorphisms (SNPs) toll-like receptors (TLRs), described as critical bacterial sensors in the gut. Here, colorectal cancer patients carrying missense TLR4 A896G (rs4986790) or C1,196T (rs4986791) SNPs and Tlr4 knockout (Tlr4-/-) mice were given irinotecan to investigate severity induced diarrhoea.Forty-six treated irinotecan-based regimens had diarrhoea...
Anemia is the defining feature in most patients with myelodysplastic syndromes (MDS), yet defects erythropoiesis have not been well characterized. We examined freshly obtained bone marrow (BM) samples for stage-specific abnormalities during terminal erythroid differentiation (TED) from 221 (MDS, n = 205 113 unique patients; normal, 16) by measuring surface expression of glycophorin A, band 3, and integrin α-4. Clinical biologic associations were sought presence or absence TED specific stage...
Aims To study the immunoexpression of proteins related to mitotic checkpoint (cell division cycle 20 (CDC20), arrest deficient 2 (MAD2)) and spindle (Aurora-B) in patients with myelodysplastic syndrome (MDS). Methods Protein expression was analysed bone marrow tissue samples from 40 MDS using immunohistochemistry. Prognostic markers (transfusion dependency, depth cytopenias, chromosomal abnormalities survival) were also studied. Results Higher MAD2 observed among platelets <50×10 9 /L...
Myelodysplastic syndrome (MDS) patients with a normal karyotype constitute heterogeneous group from biological standpoint and their outcome is often unpredictable. Interphase fluorescence in situ hybridization (I-FISH) studies could increase the rate of detection abnormalities, but previous reports literature have been contradictory. We performed I-FISH conventional karyotyping (G-banding) on 50 MDS at diagnosis, after 6 12 months or any time if transformation to acute myeloid leukemia (AML)...
Abstract Some studies show that alterations in DNA repair genes polymorphisms are associated with the pathogenesis and susceptibility of Myelodysplastic Syndrome (MDS). We genotyped 60 MDS patients for six gene polymorphisms: BRCA1 rs4793191, BRCA2 rs9567623, RAD51 rs1801320, XRCC5 rs3835, XRCC6 rs2267437 LIG4 rs1805388. The G/C heterozygote genotype rs1801320 polymorphism was a decreased chance developing ( p = 0.05). Additionally, G/G homozygous presence one cytopenia whole blood. C/G CG +...
There are previously reported data describing differences between Asian and European patients with Myelodysplastic Syndromes (MDS), few direct comparisons based on cancer registration characteristics or using cohorts to validate scoring systems. This is the first study from South-America, which attempts describe demographic, clinical features, outcome of MDS patients. We retrospectively analyzed 1,080 de novo Argentina (635), Brazil (345), Chile (100). Chilean were younger (P = 0.001) female...
The increase of H. pylori resistance to clarithromycin is a concern. This study evaluated the prevalence pylori's primary and its association with virulence factors in adult dyspeptic patients asymptomatic children. gastric mucosa from (153 gastritis, 24 cancer, 21 peptic ulcer) juice obtained by string test 23S rRNA positive children were included. was assessed TaqMan RT-PCR point mutations, A2142G and/or A2143G, markers PCR. Overall, 14.4% (32/222), 14.2% adults, 12% children, whereas...
Primary malignant breast lymphoma (PBL) is a rare disease with an incidence of 0.04-0.5% all neoplasms. The majority cases are B-cell lymphomas and the most common histologic type diffuse large (DLCL). In this study, we report our experience three PBL. treatment was same currently indicated for early stage aggressive NHL, i.e. anthracycline based chemotherapy followed by involved field radiation therapy. Unfortunately, two patients underwent mastectomy to carry out correct diagnosis. alive...