A5033987168- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Gastroesophageal reflux and treatments
- Veterinary medicine and infectious diseases
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Hepatitis C virus research
- Probiotics and Fermented Foods
- Digestive system and related health
- Microbial Metabolites in Food Biotechnology
- Whipple's Disease and Interleukins
- Platelet Disorders and Treatments
- Celiac Disease Research and Management
- Cytokine Signaling Pathways and Interactions
- Inflammatory Bowel Disease
- Intestinal and Peritoneal Adhesions
- Gastrointestinal motility and disorders
- Child Nutrition and Water Access
- Microscopic Colitis
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
Universidade Federal de Minas Gerais
2016-2025
Fundação Faculdade de Medicina
1993-2013
Universidade Federal de Santa Maria
2012
Hospital Geral de Fortaleza
2011
Universidade Federal do Ceará
2007
Tricoci University of Beauty Culture
2005
State of The Art
2004
Financiadora de Estudos e Projetos
2002
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
2002
João Pinheiro Foundation
1999
A severe burn leads to hypermetabolism and catabolism resulting in compromised function structure of essential organs. The massive release cytokines is implicated this hypermetabolic response. aim the present study was compare cytokine expression profiles from severely burned children without signs infections or inhalation injury (n = 19) normal, noninfected, nonburned 14). Bio-Plex suspension array system used measure concentration 17 cytokines. proinflammatory anti-inflammatory maximal...
Helicobacter pylori strains from 299 patients were tested in six laboratories different countries. Macrolide susceptibility of the was determined by agar dilution (17.4%) or epsilometer test (82.6%). Mutations 23S ribosomal DNA (rDNA) that are associated with macrolide resistance analyzed PCR and reverse hybridization (PCR-line probe assay [LiPA]). This method identifies A2115G, G2141A, A2142G, A2142C, A2142T, A2143G, A2143C mutations rDNA. vacA s-region (s1a, s1b, s1c, s2) m-region (m1,...
The use of a new indicator culture medium, Belo Horizonte is proposed for better colony recognition and presumptive identification Campylobacter pylori. This containing brain heart infusion sheep blood agar, was supplemented with 40 mg 2,3,5-triphenyltetrazolium chloride per liter in addition to vancomycin, nalidixic acid, amphotericin B. On pylori present unique golden colonies.
Th17 cells have been associated with immune-mediated diseases in humans but it has still not determined whether they play a role immune thrombocytopenia. We evaluated representative cytokines of the Th17, Th1, Th2 and Treg cell commitment serum patients chronic thrombocytopenia, as well source IL-17A. Higher levels IL-17A Th17-related cytokines, an increased percentage producing CD4+ neutrophils were observed patients. The involved Th1 IFN-γ, IL-2, IL12-p70 percentages also increased, IL-4...
Abstract Background Helicobacter pylori infection is one of the most common infections worldwide and associated with gastric cancer peptic ulcer. Bacterial virulence factors such as CagA have been shown to increase risk both diseases. Studies suggested a causal role for EPIYA polymorphisms in carcinogenesis, it has be geographically diverse. We studied associations between H. patterns duodenal ulcer, an ethnically admixed Western population from Brazil. was determined by PCR confirmed...
Objective Iron deficiency (ID) and iron anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection ID/IDA has been proposed the literature, currently there is no consensus. We studied effects of on a cohort children undergoing upper gastrointestinal endoscopy for abdominal pain two one developed country. Methods In total 311 (mean age 10.7±3.2 years) from Latin America - Belo Horizonte/Brazil (n = 125),...
Abstract Background Preserved skeletal muscle is essential for the maintenance of healthy bone. Loss bone mineral density (BMD) and strength, considered a predictor BMD, have been demonstrated in patients with cirrhosis, but they are poorly studied chronic hepatitis C (CHC) without cirrhosis. Thus, we aimed to evaluate prevalence low BMD its association body composition, nutritional status CHC. Methods One hundred four subjects [mean age, 50.5 ± 11.3 years; 75.0% males; 67.3% non‐cirrhotic;...
Background: Although enzyme-linked immunosorbent assay (ELISA) is highly sensitive and specific for the diagnosis of Helicobacter pylori infection in adults, their performance children still controversial. Methods: A second-generation ELISA was used to evaluate IgG response H. serum 130 consecutive who underwent upper gastrointestinal endoscopy. The presence determined antral biopsy specimens by culture, urease test, histologic analysis. Results: Sixty-eight (all 20 had duodenal ulcer) were...
A new Helicobacter species that colonizes the colonic mucosa of Wistar and Holtzman rats was isolated characterized. This bacterium gram negative, its cells were rod shaped with pointed ends, protoplasmic cylinder entwined periplasmic fibers. It catalase oxidase positive, rapidly hydrolyzed urea, susceptible to metronidazole resistant cephalothin nalidixic acid. The organism microaerophilic grew at 42°C, a feature differentiates it from two other murine intestine colonizers, hepaticus...
ABSTRACT The [ 13 C]urea breath test ( C-UBT) and Helicobacter pylori stool antigen (HpSA) for the diagnosis of H. infection in children were validated. sensitivity, specificity, positive negative predictive values 93.8, 99.1, 97.8, 98.0%, respectively, C-UBT 96.9, 100, HpSA. Both tests are appropriate diagnosing children.
The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells the contents were investigated in endoscopic biopsy specimens from patients with duodenal ulcer before after eradication Helicobacter pylori. After H. pylori both concentration (p = 0.0002) D-cell 0.01) increased significantly. Conversely, although number G-cells was unchanged, serum 0.001) decreased oxyntic D-cells did not change These results strongly suggest that hypergastrinaemia observed pylori-positive may be...
This PCR-based analysis is the first molecular epidemiological study in Brazil testing Helicobacter pylori cagA and vacA distribution adults with gastric complaints, that includes a large number of carcinoma patients. Multiple-strain infection was identified 11/13.4% s1-m1 cagA+ genotypes were most common patients non-mixed infection. All s1 strains s1b, so subtyping not useful. s1b-m1 associated higher prevalence peptic ulcer than s2-m2 cagA− ones. In conclusion, genotyping may have...
ABSTRACT The presence of Helicobacter DNA species has been investigated in the biliary epithelium patients with diseases. However, conflicting results have observed that may due to small number subjects studied, difficulty obtaining a healthy control group, absence controlling for confounding factors, or differences among populations. Therefore, we by culture and nested PCR 16S rRNA genes gallbladder tissue bile from 46 Brazilian 18 without cholelithiasis. group was mainly composed liver...
To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients matched controls. The presence of A gene was investigated by PCR in H. pylori isolates biopsy specimens. significant found status distal for both the intestinal diffuse types tumor males females. On other hand, no observed proximal carcinoma.
ABSTRACT The babA2 and cagA genes were investigated in 208 Brazilian Helicobacter pylori strains. A strong association between duodenal ulcer or gastric carcinoma was observed, even after adjusting for confounding factors, such as age, gender, status. -positive strains also independently associated with H . -related diseases.