A5100779576- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Diet, Metabolism, and Disease
- Protein Degradation and Inhibitors
Nankai University
2016-2025
Tianjin Medical University
2005-2025
Tianjin First Center Hospital
2020-2025
Digestive Health Research Institute
2024
McMaster University
2014-2024
Tianjin University of Traditional Chinese Medicine
2023-2024
Tianjin People's Hospital
2019-2024
Beijing University of Chemical Technology
2024
First Affiliated Hospital of Bengbu Medical College
2019
Lymphoma Research Foundation
2010-2017
Primary liver cancer (PLC) is the sixth most frequently occurring cancer, representing one of top 5 leading causes cancer-related mortality worldwide. Recently, researchers have focused more on impact living habits incidence and development tumours. This study reports a relationship between sleep traits PLC.In this study, we used published genome-wide association studies to obtain exposure factors 6 traits. Mendelian randomization (MR) analysis was assess causal PLC via inverse-variance...
Norcantharidin (NCTD), a cantharidin derivative, induces ROS generation and is widely used to treat CRC. In this study, we clarified the role mechanism of action norcantharidin in increasing CRC sensitivity radiotherapy. We treated cell lines LoVo DLD-1 with NCTD (10 or 50 μmol/L), ionizing radiation (IR, 6 Gy), combination two found that significantly inhibited proliferation cells enhanced their induced by decreasing mitochondrial membrane potential, permeability, promoting cytochrome C...
The majority of studies regorafenib now were small-sample and single-arm, which potentially limits the strength evidence. We conduct study to identify efficacy safety for patients with metastatic colorectal cancer (mCRC) in real-world applications.
Background: Bevacizumab is a monoclonal antibody (mAb) against vascular endothelial growth factor (VEGF) and used for treatments of various cancers. Due to the high costs bevacizumab treatments, biosimilar provides an affordable alternative therapy cancer patients. Methods: In this randomized, double-blind, multicenter, phase 3 study, locally advanced, metastatic or recurrent non-squamous non-small cell lung (NSCLC) patients with wild-type epidermal receptor were enrolled randomized (1:1)...
MDSCs, which are defined as a kind of negatively regulatory cells, could suppress T cell immune response in many tumor-bearing animal models and cancer patients. We supposed that MDSCs also contributed to the impaired antitumor immunity MDS. Here we demonstrated STAT3-ARG1 pathway be critical signal transduction regulated MDSCs-mediated immunosuppression. Increased was revealed MDS patients when compared healthy controls. Especially, performed higher activated STAT3 CCR2 expression high-risk...
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with an incompletely understood pathogenesis. Long-standing colitis associated increased risk colon cancer. Despite availability various anti-inflammatory and immunomodulatory drugs, many patients fail to respond pharmacologic therapy some experience drug-induced adverse events. Dietary supplements, particularly saffron (Crocus sativus), have recently gained appreciable attention in alleviating...
Abstract Aim Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to anatomical site. We explored risk factors for four groups neoplasms (CRN) at different sites. Methods extracted data from database Tianjin Colorectal Cancer Screening Program 2010 2020. According CRN sites, patients were divided into groups: proximal colon group, distal rectum multiple Binary logistic regression analysis was used explore differences in Results The numbers...
Abstract Pancreatic cancer (PC) has become a worldwide challenge attributed to its difficult early diagnosis and rapid progression. Treatments continue be limited besides surgical resection. Hence, we aimed discover novel biological signatures as clinically effective therapeutic targets for PC via the mining of public tumor databases. We found that epiphycan (EPYC) could function an independent risk factor predict poor prognosis in based on integrated bioinformatics analysis. downloaded...
This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). phase II (ClinicalTrials.gov NCT04324879. Registered March 27, 2020) comprised run-in stage and 2. R/R FL patients after ≥2 lines therapies received oral 20 mg TQ-B3525 once daily a 28-day cycle until intolerable toxicity or disease progression. Primary endpoint was independent review committee (IRC)-assessed...
Abstract The prediction of degradation and remaining useful life (RUL) for mechanical equipment has received widespread attention. Due to the large number components varying operating conditions, it is difffcult extract features. This paper proposes a generalized enhanced spatiotemporal global (ESTG) competitive network predicting life. model mainly includes spatial competition (SC) module, temporal (TC) (GC) module. SC module focuses on feature mining multi-source data, which can...
Chronic lymphocytic leukemia (CLL) remains incurable with current standard therapy. We have previously reported that an increased expression of interleukin-6 (IL-6) receptor CD126 leads to resistance CLL cells chemotherapy and worse prognosis for patients CLL. In this study, we determine whether autocrine IL-6 production by B is associated poor clinical outcome explore IL-6-mediated survival mechanism in primary cells. Our results demonstrate higher levels are significantly shorter absolute...
Background: Microsatellite-stable (MSS) colon adenocarcinoma (COAD) patients are not sensitive to immune checkpoint inhibitors. Here, we focused on analyzing the relationship between homologous recombination repair (HRR)-related gene mutations and clinical immunotherapy responses in MSS COAD. Methods: The mutational landscape was profiled a cohort of 406 Chinese COAD via next-generation sequencing (NGS). Correlations HRR tumor immunity or outcomes two genomic datasets were analyzed...
The purpose of this study was to compare the efficacy and safety a single subcutaneous injection pegylated filgrastim with daily as prophylaxis for neutropenia induced by commonly used chemotherapy regimens. Fifteen centers enrolled 337 chemotherapy-naive cancer patients normal bone marrow function. All randomized into AOB BOA arms received two cycles chemotherapy. Patients dose 100 µg/kg in cycle 1 (AOB) or 2 (BOA) doses 5 µg/kg/day (AOB). Efficacy parameters were recorded. primary end...
The purpose of this study was to examine the incidence Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma elderly in a representative northern Chinese population. Overall, 212 cases primary were analyzed for EBV-positive status by detection EBV-encoded RNA using situ hybridization. Immunophenotypic identity verified streptavidin-biotin peroxidase system markers CD20, CD3, CD10, BCL6 and MUM1. prevalence patients 3.8% (eight 212). All eight negative CD10 immunostaining. is less...
Epigenetics serve a key role in peripheral T cell lymphoma (PTCL). The purpose of the present study was to investigate clinical significance enhancer zeste homolog 2 (EZH2) and histone deacetylase 1 (HDAC1/2) expression PTCL. A total 82 patients were enrolled study, including 43 with PTCL not otherwise specified (PTCL-NOS), 10 angioimmunoblastic T-cell (AITL), 14 natural killer/T-cell (NK/TCL) 15 anaplastic large (ALCL). EZH2 HDAC1/2 detected by immunohistochemistry any correlations between...
Abstract HLX01 (HanliKang ® ) is a rituximab biosimilar that showed bioequivalence to reference in untreated CD20-positive diffuse large B-cell lymphoma (DLBCL) the phase 3 HLX01-NHL03 study. Here, we report 5-year follow-up results from open-label extension part. Patients were randomised either plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or CHOP (H-CHOP) every 21 days for up six cycles. The primary efficacy endpoint was overall survival (OS), secondary...
Phosphatidylinositol 3-kinase (PI3K) inhibitors transformed management of various malignancies. This study preclinically characterized TQ-B3525 (dual PI3Kα/δ inhibitor) and assessed the recommended phase 2 dose (RP2D), safety, efficacy, pharmacokinetics in relapsed or refractory (R/R) lymphoma advanced solid tumors (STs).
The randomized phase 3 LYM3001 trial in relapsed follicular lymphoma (FL) demonstrated higher overall (ORR) and complete response (CR) rates prolonged progression-free survival (PFS) with bortezomib-rituximab versus rituximab. We report findings high-risk patients (FL International Prognostic Index [FLIPI] score ≥3, high tumor burden by modified Groupe d'Etude des Lymphomas Folliculaires [GELF] criteria). Patients aged ≥18 years grade 1/2 FL, ≥1 measurable lesion, documented relapse or...