A5076428327- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- CNS Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Lipid metabolism and disorders
- Fatty Acid Research and Health
- Histone Deacetylase Inhibitors Research
- Biosimilars and Bioanalytical Methods
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Airway Management and Intubation Techniques
- Ultrasound and Hyperthermia Applications
Affiliated Hospital of North Sichuan Medical College
2021-2025
Nanchang University
2010-2025
Second Affiliated Hospital of Nanchang University
2010-2025
Weifang Medical University
2024-2025
Jilin University
2025
Institute of Crop Sciences
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Chinese PLA General Hospital
2019-2024
Dongguan University of Technology
2024
People's Liberation Army No. 150 Hospital
2021-2024
Abstract Derived from our original nomogram study by using the risk variables multivariable analyses in derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated anthracycline-based chemotherapy, we propose an easily used nomogram-revised index (NRI), validated it and compared Ann Arbor staging, International Prognostic Index (IPI), Korean (KPI), prognostic natural killer lymphoma (PINK) for overall survival (OS) prediction examining...
Abstract Background Peripheral T cell lymphoma (PTCL) is a rare disease and recent approved drugs for relapsed/refractory (r/r) PTCL provided limited clinical benefit. We conducted this study to evaluate the efficacy safety of geptanolimab (GB226), an anti-PD-1 antibody, in r/r patients. Methods did single-arm, multicenter phase 2 across 41 sites China. Eligible patients with received 3 mg/kg intravenously every weeks until progression or intolerable toxicity. All who at least one dose...
Abstract Purpose: To investigate the efficacy and safety of novel orally active PI3Kδ inhibitor in relapsed and/or refractory patients with follicular lymphoma (FL) who had received at least two prior systemic treatments. Patients Methods: Histologically confirmed FL disease progression after receiving second-line or greater therapy were enrolled. Linperlisib was administered 80 mg every day, a 28-day cycle until intolerable toxicity occurred. The primary outcome for study objective response...
Abstract The present study investigated the survival benefit of non–anthracycline (ANT)-based vs ANT-based regimens in a large-scale, real-world cohort patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL). Within China Lymphoma Collaborative Group (CLCG) database (2000-2015), we identified 2560 newly diagnosed who received chemotherapy or without radiotherapy. Propensity score matching (PSM) and multivariable analyses were used to compare overall (OS)...
Patients with peripheral T-cell lymphomas (PTCL) in the relapsed or refractory (r/r) setting have only a limited number of therapies available, and prognosis is extremely poor. SHR2554 an oral inhibitor against EZH2, rational therapeutic target for lymphomas.
The regiospecific characteristics of n-3 polyunsaturated fatty acids (PUFAs) in triacylglycerol (TAG) significantly affect the physicochemical and physiological properties marine fish oils. In this study, TAG molecular species composition positional distributions were investigated three rich omega-3 PUFAs (anchovy, tuna, salmon). distribution was measured with allylmagnesium bromide (AMB) degradation method. compositions analyzed HPLC identified APCI/MS. DHA preferentially distributed at...
Abstract We aimed to determine the survival benefits of chemotherapy (CT) added radiotherapy (RT) in different risk groups patients with early‐stage extranodal nasal‐type NK/T‐cell lymphoma (ENKTCL), and investigate postponing RT based on induction CT responses. A total 1360 who received or without new‐regimen from 20 institutions were retrospectively reviewed. The had alone, followed by (RT + CT), (CT RT). stratified into using nomogram‐revised index (NRI). comparative study was performed...
信息科学 第 50 卷 9 期 早在 2014 年, 深度学习的诸多缺陷不断地被发现, 预示着这条道路遇到了瓶颈.下面仅以基于深 度学习的图像识别的一个例子说明这个问题 (材料引自本团队的工作).文献 [32] 表示利用基于动量的 迭代快速梯度符号法 (momentum iterative fast gradient sign method, MI-FGSM) 对 Inception v3 深度 网络模型实施攻击的结果.无噪声的原始图像 --阿尔卑斯山 (Alps), 模型以 94.39% 的置信度得到 正确的分类.利用 MI-FGSM 方法经 10 次迭代之后生成攻击噪声, 将此攻击噪声加进原图像后得到攻 击样本.由于加入的噪声很小, 生成的攻击样本与原始图几乎没有差异, 人类无法察觉, 但 模型却以 99.99% 的置信度识别为 "狗".深度学习为何如此脆弱, 这样容易受攻击, 被欺骗和不安全.原因只能从机器学习理论本身去寻 找. 机器学习的成功与否与 3 项假设密切相关, 由于观察与测量数据的不确定性, 所获取的数据一定 不完备和含有噪声, 这种情况下, 神经网络结构...
The continuous emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants means there is a need to explore additional strategies develop broad-spectrum vaccines or therapeutics for individuals remaining at risk disease 2019 (COVID-19). Neutralizing monoclonal antibody (mAb) that binds the conserved S2 subunit SARS-CoV-2 spike (S) protein alone, in combination with mAb receptor-binding domain (RBD) S protein, might be effective eliciting protection from infection...
<h3>Importance</h3> Prognosis of early-stage extranodal natural killer/T-cell lymphoma (NKTCL) is usually estimated and stratified at diagnosis, but how the prognosis actually evolves over time for patients who survived after curative treatment unknown. <h3>Objective</h3> To assess conditional survival failure hazard based on risk categories, previous survival, treatment. <h3>Design, Setting, Participants</h3> This retrospective cohort study reviewed clinical data 2015 with NKTCL treated...
BackgroundBlood-based biomarker such as circulating tumor DNA (ctDNA) has emerged a promising tool for assessment of response to immunotherapy in solid tumors; But hematological malignances, evidences are still lacking support its clinical utility. In current study the feasibility ctDNA prediction and monitoring anti-PD-1 therapy Chinese patients with relapsed or refractory classical Hodgkin lymphoma (r/r cHL) was assessed.MethodsA total 192 plasma samples from 75 r/r cHL were collected at...
Objective: To assess the efficacy and safety of novel histone deacetylase inhibitor, chidamide, in combination with cyclophosphamide,doxorubicin, vincristine, etoposide, prednisone (Chi-CHOEP) for untreated peripheral T-cell lymphoma (PTCL). Methods: A prospective, multicenter, single arm, phase 1b/2 study was conducted. total 128 patients PTCL (18–70years age) were enrolled between March 2016 November 2019, treated up to 6 cycles Chi-CHOEP regimen.In 1b study, 3 dose levels chidamide...
Objective: To compare the impact of manual right arm blood pressure measurement with computer-controlled meter (CCBPM) on detection rate hypertension among elderly individuals. Method: This was a cross-sectional study. Elderly residents undergoing routine health check-up in village Jiangxi Province from April to June 2024 were enrolled. Manual measurements performed using an electronic sphygmomanometer, while standardized dual-arm synchronized assessments conducted CCBPM. Blood data recorded...
The successful commercialization of perovskite photovoltaics requires comprehension the effects fatigue aging on photoelectric performance devices through frequency temperature variation tests. In this study,...
Sufentanil is a potent opioid analgesic frequently used to suppress the tracheal intubation response. The pathophysiological changes of obesity may affect pharmacokinetics and increase risk opioid-induced adverse effects. Dexmedetomidine as an adjunct anesthetic induction could save dosage sufentanil attenuate hemodynamic response intubation. This study was aimed at investigating effect intravenous dexmedetomidine premedication on median effective concentration (EC50) for in obese patients....