A5102712908- Multiple Myeloma Research and Treatments
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Selenium in Biological Systems
- CAR-T cell therapy research
- Arsenic contamination and mitigation
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Amino Acid Enzymes and Metabolism
- Cell death mechanisms and regulation
- Platelet Disorders and Treatments
- Biosimilars and Bioanalytical Methods
- Acute Myeloid Leukemia Research
- Air Quality and Health Impacts
- RNA Interference and Gene Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Phagocytosis and Immune Regulation
- Adolescent and Pediatric Healthcare
First Affiliated Hospital of Nanchang University
2015-2024
Nanchang University
2015-2024
Southern University of Science and Technology
2024
University of Michigan
2010-2020
Third Hospital of Nanchang
2018
Third Affiliated Hospital of Nanchang University
2018
Second Affiliated Hospital of Nanchang University
2016
Nano and Advanced Materials Institute
2014
Tsinghua University
2014
Dana-Farber Cancer Institute
2010
The chemopreventive effects of selenium have been extensively examined, but its role in cancer development or as a chemotherapeutic agent has only recently explored. Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) shown to bind covalently and deficiency associated with esophageal adenocarcinoma (EAC), we examined EAC potential effect on chemosensitivity the presence selenium.SELENBP1 expression level copy number variation were determined by oligonucleotide microarrays, real-time...
Multiple myeloma (MM) is a heterogeneous disease with poor prognosis. Circulating microRNAs (miRNAs) have shown potential as non-invasive prognostic biomarkers for diseases. miR-20a has been involved in various human cancers, and the phosphatase tensin homolog/phosphoinositide 3-kinase/protein kinase B (PTEN/P13K/Akt) signaling pathway plays key role cell proliferation, migration apoptosis. Here, we investigated effect of on PTEN/PI3K/Akt during MM Reverse transcription quantitative...
Abstract Objectives Aspirin ( ASA ) has been frequently used for thromboprophylaxis in patients with multiple myeloma MM when treated thalidomide or lenalidomide. Despite the well‐recognized chemopreventive role of some solid tumors particularly colon cancer, whether displays antimyeloma activity remains unclear. Methods MM1.S and RPMI‐8226 cell lines harboring K‐Ras N‐Ras mutation, respectively, were various concentrations different hours. The proliferation apoptosis performed to explore...
Pentose phosphate pathway (PPP) is a metabolic that generates NADPH and pentose. PPP genes have been reported to be primarily or secondarily upregulated in many cancers. We aimed study the general alteration of acute myelogenous leukemia (AML). performed data mining analysis Cancer Genome Atlas (TCGA) AML dataset for genetic gene set. In vitro studies including proliferation, migration, invasion assays, together with metabolite consumption oxidation were performed. 61 % patients AML. The...
Circulating microRNAs (miRNAs) play an essential role in the development and progression of acute myeloid leukemia (AML). However, clinical value serum miR-217 AML remained poorly known.This study aimed to explore significance AML.Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was performed detect levels blood samples obtained from 89 patients 60 healthy controls.The results showed that expression significantly decreased compared controls. Likewise, were greatly...
Multiple myeloma (MM) was characterized by frequent mutations in KRAS/NRAS/BRAF within the EGFR pathway that could induce resistance to inhibitors. We here report inhibition solely exhibited moderate wildtype (triple-WT) MM cells, whilst had no effect cells with any of mutated genes. The inhibitory conferred induction pentose phosphate (PPP) when were treated Gefitinib, inhibitor. Combination Gefitinib PPP inhibitor 6AN effected synergistically triple-WT cells. be restored addition NADPH....
Abstract HLX01 (HanliKang ® ) is a rituximab biosimilar that showed bioequivalence to reference in untreated CD20-positive diffuse large B-cell lymphoma (DLBCL) the phase 3 HLX01-NHL03 study. Here, we report 5-year follow-up results from open-label extension part. Patients were randomised either plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or CHOP (H-CHOP) every 21 days for up six cycles. The primary efficacy endpoint was overall survival (OS), secondary...
Increasing evidence has revealed that microRNAs (miRNAs) are closely associated with multiple myeloma (MM) pathogenesis and progression. Therefore, an in‑depth understanding of the biological functions miRNAs in MM may be helpful for identification promising therapeutic techniques patients MM. miRNA‑765 (miR‑765) been reported to dysregulated many types human cancer. However, expression pattern, specific roles underlying mechanisms miR‑765 remain largely unknown. In present study, plasma...
PFKP
Currently, the prognosis of acute myeloid leukemia (AML) is poor. In AML microenvironment, bone marrow (BM) mesenchymal stem cells (BMMSCs) serve an important role in protecting from chemotherapy‑induced apoptosis. The present study aimed to evaluate expression fibroblast activation protein α (FAPα) BMMSCs and BM biopsy samples via flow cytometry, reverse transcription‑quantitative PCR immunohistochemistry, as well identify correlation between FAPα with clinical parameters survival newly...
In our previous study, it was found that aspirin (ASA) exerted antimyeloma actions in vivo and vitro. The resistance to bortezomib (BTZ) multiple myeloma (MM) is partly due AKT activation the upregulation of survivin induced by BTZ, which are targets ASA gastric ovarian cancer, respectively. Thus, present study investigated interaction between BTZ MM further clarified underlying mechanisms. MM1.S RPMI‑8226 cell lines harboring N‑ K‑Ras mutations, respectively, were treated with 2.5 mM ASA,...
We previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases lung cancer cell proliferation by activating RAS signaling and CYP24A1 knockdown inhibits tumor growth. However, the mechanism CYP24A1-mediated remains unclear. Here, we conducted synchronization biochemical experiments in adenocarcinoma cells, revealing a link between anaphase-promoting complex (APC), key cycle regulator. demonstrate expression is cycle–dependent; it was higher...
Background: Multiple myeloma (MM) is a malignant hematopoietic disease that usually incurable. However, the ubiquitin-proteasome system (UPS) genes have not yet been established as prognostic predictor for MM, despite their potential applications in other cancers. Methods: RNA sequencing data and corresponding clinical information were acquired from Myeloma Research Foundation (MMRF)-COMMPASS served training set (n=787). Validation of prediction signature conducted by Gene Expression Omnibus...
To explore the inhibitory effect of curcumin on proliferation CD34(+) acute myeloid leukemia cells and its mechamism.KG1a Kasumi-1cell lines were treated with different concentrations (0, 40, 60, 80 µmol/L). The cell viability was detected by trypan blue staining count. distribution NF-κB P65 subunit analyzed immunofluorescence Western blot.The inhibited KG1a Kasumi-1 in a dose-dependent manner. blotting showed that led to significant down-regulation nuclear protein expression....