A5002561193- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Esophageal Cancer Research and Treatment
- Ubiquitin and proteasome pathways
- Global Cancer Incidence and Screening
- S100 Proteins and Annexins
- Hippo pathway signaling and YAP/TAZ
- Cancer Genomics and Diagnostics
- Tannin, Tannase and Anticancer Activities
- Genomic variations and chromosomal abnormalities
- Natural Compounds in Disease Treatment
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Thyroid Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Cancer survivorship and care
Nanjing Medical University
2021-2025
Anhui Medical University
2021-2024
First Affiliated Hospital of Anhui Medical University
2021-2024
Wuhan University of Science and Technology
2022-2024
The First People’s Hospital of Lianyungang
2022-2024
Union Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Third Affiliated Hospital of Southern Medical University
2023-2024
The Barbara Ann Karmanos Cancer Institute
2024
Wayne State University
2024
Cuproptosis is a new modality of cell death regulation that currently considered as cancer treatment strategy. Nevertheless, the prognostic predictive value cuproptosis-related lncRNAs in breast (BC) remains unknown. Using lncRNAs, this study aims to predict immune microenvironment and prognosis BC patients. develop therapeutic strategies target disease.
Multiple new subtypes of breast cancer (BRCA) are identified in women each year, rendering BRCA the most common and rapidly expanding form females globally. NUF2 has been as a prognostic factor various human cancers, regulating cell apoptosis proliferation. However, its role prognosis not clarified. This study explored development using informatic analysis combined with vivo intracellular studies. Through online website TIMER, we evaluated transcription profile across variety different types...
Abstract Background With increasing incidence and mortality, colorectal cancer (CRC) seriously endangers human health. LARP6 , a member of La-related protein ( LARP ) family, is RNA binding probably associates with CRC progression, but its specific roles mechanisms in still remain unknown. Method Quantitative real-time PCR (qPCR), western blot, immunohistochemistry were employed to examine expression tissues. Using the stable overexpression or interference cell lines, effect on progression...
Abstract Background: Early detection of esophageal squamous cell carcinoma (ESCC) can considerably improve the prognosis patients. Aberrant cell-free DNA (cfDNA) methylation signatures are a promising tool for detecting ESCC. However, available markers based on still inadequate. This study aimed to identify ESCC-specific cfDNA and evaluate diagnostic performance in early Methods: We performed whole-genome bisulfite sequencing (WGBS) 24 ESCC tissues their normal adjacent tissues. Based WGBS...
Abstract Objectives The aim was to explore the prevalence and independent risk factors for anxiety depression in RA patients assess consistency between hospital scale (HADS) Zung’s self-rating scale/depression (SAS/SDS). Methods In total, 160 60 healthy controls (HCs) were enrolled consecutively, HADS SAS/SDS completed. Results HADS-defined rate, SAS-defined rate SDS-defined 36.9, 36.3, 29.4 29.4%, respectively, patients, all of which much higher than HCs (all P < 0.001). A relatively...
Genome-wide association studies have identified thousands of genetic variants associated with non-small cell lung cancer (NSCLC), however, it is still challenging to determine the causal and improve disease risk prediction. Here, we applied massively parallel reporter assays perform NSCLC variant-to-function mapping at scale. A total 1249 candidate were evaluated, 30 potential within 12 loci identified. Accordingly, proposed three architectures underlying susceptibility: multiple in a single...
Cervical cancer ranks fourth in women terms of incidence and mortality. The RNA-binding protein YTH N6-methyladenosine F2 (YTHDF2) contributes to progression by incompletely understood mechanisms. We show how YTHDF2 controls the fate cervical cells whether could be a valid target for therapy cancer. Sphere formation alkaline phosphatase staining assays were performed evaluate tumor stemness following knockdown. Apoptosis was detected flow cytometry TUNEL assay. compounds 4PBA SP600125 used...
Clear cell renal carcinoma (ccRCC), the most common type of (RCC), is not sensitive to traditional radiotherapy and chemotherapy. The polyphenolic compound Gallic acid (GA) can be naturally found in a variety fruits, vegetables plants. Autophagy, an intracellular catabolic process, regulates lysosomal degradation organelles portions cytoplasm. It was reported that autophagy GA could affect development several cancers. Therefore, aim present study evaluate effects on ccRCC clarify role this...
N6-methyladenosine (m6A) modification is a common epigenetic modification. It reported that lncRNA can be regulated by m6A Previous studies have shown lncRNAs associated with regulation (m6A-lncRNAs) serve as ideal prognostic biomarkers. However, whether are involved in colon adenocarcinoma (COAD) needs further exploration. The objective of this study was to construct an m6A-lncRNAs-based signature for patients COAD. We obtained the RNA sequencing data and clinical information from Cancer...
Breast cancer is a common malignant tumors in women. TIMM8A was up-regulated different cancers. The aim of this work to clarify the value diagnosis, prognosis Cancer (BC), and its association with immune cells detection points. Gene mutations.The transcription expression profile between BC normal tissues downloaded from Genome atlas (TCGA). protein evaluated by human map. correlation clinical features analyzed using R package establish ROC diagnostic curve. cBioPortal MethSurv were used...
Sepsis is organ dysfunction due to the host's deleterious response infection, and kidneys are one of organs damaged in common sepsis. Sepsis-associated acute kidney injury (SA-AKI) increases mortality patients with Although a substantial volume research has improved prevention treatment disease, SA-SKI still significant clinical concern. Aimed use weighted gene co-expression network analysis (WGCNA) immunoinfiltration study SA-AKI-related diagnostic markers potential therapeutic targets....
Aims and objectives To compare evaluate the reliability, validity, feasibility, clinical utility, nurses’ preference of Premature Infant Pain Profile‐Revised, Neonatal Pain, Agitation, Sedation Scale, Acute Assessment Scale used for procedural pain in ventilated neonates. Background Procedural is a common phenomenon but undermanaged underassessed hospitalised Information clinician selecting measurements to improve neonatal care outcomes still limited. Design A prospective observational study...
HBV-associated hepatitis B virus x protein (HBx) plays multiple roles in the development of hepatocellular carcinoma. In our prior study, we discovered that miR-187-5p expression was inhibited by HBx. To investigate underlying molecular mechanism HBx-mediated downregulation carcinoma cells, effects HBx and on hepatoma cell were observed, as well their interactions. Through vitro vivo experiments, demonstrated overexpression proliferation, migration, invasion. Simultaneously, observed a...
Background Pathological complete response (pCR) is considered a surrogate for favorable survival in breast cancer (BC) patients treated with neoadjuvant chemotherapy (NACT), which the goal of NACT. This study aimed to develop and validate nomogram predicting pCR probability BC after NACT based on clinicopathological features. Methods A retrospective analysis 527 between January 2018 December 2021 from two institutions was conducted. Univariate multivariate logistic regression analyses were...
The objective of this study was to examine the association fetal macrosomia with maternal D-dimer and blood lipid levels, explore whether lipids, either alone or in combination traditional risk factors at hospital birth, could be used predict subsequent delivery macrosomia.From April 2016 March 2017, 10,396 women singleton pregnancy giving birth around 28-41 weeks gestation were recruited into present study. levels measured admission; data on outcomes obtained from records.Multivariate...
Purpose: To explore the effect of DSG2 on growth cervical cancer cells and its possible regulatory mechanism. Methods: The expression levels survival prognosis ADAM17 in squamous cell carcinoma tissues adjacent normal were analyzed by bioinformatics. CCK-8 assay, colony formation assay Transwell used to detect effects proliferative activity, ability migration SiHa Hela cells. DSG 2 level transcription translation was detected qPCR Western blot experiments. interaction between c-MYC...
Abstract Background In this study, we investigated the relationship between risk of postoperative progressive disease (PD) in breast cancer and depression sleep disorders order to develop validate a suitable prevention model. Methods A total 750 patients with were selected from First People’s Hospital LianYunGang, indices two groups (an event group non-event group) compared prediction The depression, disorders, PD events was using follow-up data patients. Results SAS, SDS, AIS scores...