A5102922656- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Parathyroid Disorders and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Thyroid Cancer Diagnosis and Treatment
- Breast Implant and Reconstruction
- Cardiac Ischemia and Reperfusion
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Thyroid and Parathyroid Surgery
- Reconstructive Facial Surgery Techniques
- Wound Healing and Treatments
- Genetic Syndromes and Imprinting
- Global Cancer Incidence and Screening
- Graphene and Nanomaterials Applications
- Nonmelanoma Skin Cancer Studies
- RNA and protein synthesis mechanisms
- Peroxisome Proliferator-Activated Receptors
- Renal cell carcinoma treatment
- Hydrogels: synthesis, properties, applications
Ruijin Hospital
2020-2025
Shanghai Jiao Tong University
2021-2025
Huazhong University of Science and Technology
2019-2025
Union Hospital
2019-2025
Union Hospital
2019-2023
Gannan Normal University
2020
Nantong University
2017
Tongji University
2010
Shanghai Tenth People's Hospital
2010
Suzhou Research Institute
2006
The unique properties of self-healing materials hold great potential in the field biomedical engineering. Although previous studies have focused on design and synthesis materials, their application vivo settings remains limited. Here, we a series biodegradable biocompatible elastomers (SHEs) with tunable mechanical properties, apply them to various disease models vivo, order test reparative multiple tissues at physiological conditions. We validate effectiveness SHEs as promising therapies...
Wound dressings composed of natural polymers, such as type I collagen, possess good biocompatibility, water holding capacity, air permeability, and degradability, can be used in wound repair. However, due to the persistent oxidative stress area, migration proliferation fibroblasts might suppressed, leading poor healing. Thus, collagen-containing scaffolds are not suitable for accelerated Antioxidant N-acetyl cysteine (NAC) is known reduce reactive oxygen species (ROS) has been widely clinic....
Cardiovascular diseases such as myocardial infarction (MI) are among the major causes of death worldwide. Although intramyocardial injection hydrogels can effectively enhance ventricular wall, this approach is limited because its restriction to poor vascularization in infarcted myocardium. Here, we reported a new type hydrogel composed alginate (ALG) and hyaluronic acid (HA) with lyophilized platelet-rich fibrin (Ly-PRF) for releasing abundant growth factors realize their respective...
The sequestration of nanoparticles by mononuclear phagocyte system is a challenge for the use nanotherapy treating cardiovascular diseases due to conventionally perceived loss therapeutic potency. Here, we revitalize unlocking an alternative route in which nanomedicines are redirected spleen, leveraging its potential as highly efficient and targeted site remote conditioning, or tele-conditioning myocardial reperfusion injury. theoretical foundation underpinning splenogenic nature recruited...
Clear cell renal carcinoma (ccRCC) poses significant clinical challenges due to its high metastatic rate at diagnosis and resistance conventional therapies. The magnesium transporter NIPAL4, involved in lipid metabolism ion homeostasis, has recently been implicated cancer biology but remains understudied ccRCC. In this study, we identifies NIPAL4 as a potential prognostic marker therapeutic target High expression is associated with poor prognosis contributes tumor proliferation migration....
Abstract Ginsenoside Rh2 (G-Rh2) has well-established potent antitumor activity; yet, the effects of G-Rh2 on immune and metabolism regulation in cancer treatment, especially non-small cell lung (NSCLC) remain unclear. We showed that had a synergistic effect with cyclophosphamide (CY) mice NSCLC, improved deficiency caused by CY. Consistently, exhibited no inhibitory tumor growth T cells-deficient nude mice. Furthermore, treatment triggered oxidative decomposition fatty acid (FA), suppressed...
Abstract Associated with persistent oxidative stress, altered inflammatory responses, poor angiogenesis and epithelization, wound healing in diabetic patients is impaired. N-acetylcysteine (NAC) reported to resist excess reactive oxygen species (ROS) production, prompt maturation of the epidermis. Studies have revealed that graphene oxide (GO) can regulate cellular behavior form cross-links naturally biodegradable polymers such as collagen (COL) construct composite scaffolds. Here, we a...
Fibrotic diseases remain a substantial health burden with few therapeutic approaches. A hallmark of fibrosis is the aberrant activation and accumulation myofibroblasts, which caused by excessive profibrotic cytokines. Conventional anticytokine therapies fail to undergo clinical trials, as simply blocking single or several antifibrotic cytokines cannot abrogate microenvironment. Here, biomimetic nanoparticles based on autologous skin fibroblasts are customized decoys neutralize multiple...
Myocardial infarction (MI) is a major cause of mortality worldwide. The limitation regenerative therapy for MI poor cardiac retention therapeutics, which results from an inefficient vascular network and targeting ability. In this study, two-layer intrinsically magnetic epicardial patch (MagPatch) prepared by 3D printing with biocompatible materials like poly (glycerol sebacate) (PGS) designed, (ε-caprolactone) (PCL), NdFeB. structure ensured that the MagPatch multifariously utilized force...
The scope of neck lymph node dissection remains controversial for unilateral papillary thyroid carcinoma (UPTC) patients with no clinical evidence metastasis (cN0). This study aims to build and validate a model predicting central (CLNM) in UPTC through preoperative basic information intraoperative rapid frozen pathology results. Retrospective analysis covered 1928 PTC from the Wuhan Union Hospital database (2010–2020), randomly split into training validation sets 7:3 ratio. Univariate...
Complete tissue recovery following traumatic injury remains a major clinical challenge. While adhesives show promise for managing injuries, developing materials with robust wet adhesion and high biocompatibility difficult. Decellularized extracellular matrix (ECM)-derived are widely utilized in engineering due to their superior bioactivity. In this study, adhesive is developed by functionalizing ECM dopamine. The resulting ECM-dopamine exhibits strong excellent biocompatibility. Furthermore,...
The gut microbiota metabolite, short-chain fatty acids (SCFAs), can protect against multiple cardiovascular diseases, while the molecular targets and underlying mechanisms need to be elucidated. One of primary SCFA benefits was direct activation a group G-protein-coupled receptors (GPCRs), termed free acid (FFARs), FFAR2 (GPR43), FFAR3 (GPR41). At present, distribution FFAR2/3 in cardiac cells has not been entirely clarified. Using 18 public single-cell RNA-seq single-nuclear data human...
// Yingcheng Wu 1, * , Qianqian Ju 2, 4, Bei Qian Feng Zhang 3 and Hui Shi 4 1 Medical School of Nantong University, Jiangsu 226001, China 2 Laboratory Animal Center Nursing, Department Thoracic Surgery, Affiliated Hospital These authors contributed equally to this work shared the co-first authorship Correspondence to: Shi, email: disney1982@163.com Keywords: PD-1 inhibitor; age; meta-analysis; overall survival; progression-free survival Received: September 19, 2017 Accepted: December 04,...
As a permanent soft tissue filler, the use of polyacrylamide hydrogel (PAAG) has been banned due to its myriad complications. However, large number symptomatic and asymptomatic patients whose breasts were augmented with gel injection have continued seek medical advice. This study aimed explore standardized clinical management breast augmentation PAAG.The authors retrospectively collected data total 325 following PAAG for from 2003 2018. Magnetic resonance imaging (MRI) was performed...
Background/Purpose: Inconsistent data are available on the various types of skin, their prevalence and characterization, particularly regarding Asian skins. This observation prompted to conduct a large study in China assess oily skin identify specific factors related that type skin. Methods: The multicentre trial involved 1787 Chinese women Shenyang, Harbin, Beijing, Chengdu Suzhou, between 18 65 years age. Data history acne, presence environmental detailed self‐evaluation were collected...
Parathyroid carcinoma (PC) is a rare but often lethal malignancy for which staging system, prognostic indicators, and treatment guidelines are still not established. We aimed to explore the parameters construct nomogram cancer-specific survival (CSS) of PC.A retrospective analysis 604 PC patients in SEER database from 2001 through 2018 was performed. All cases were randomly assigned training cohort (n = 424) or validation 180) at ratio 7:3. The Kaplan-Meier method Cox regression model...
Prostate cancer (PCa) is a form of malignancy that harms the health status elderly men worldwide. It unclear which radical prostatectomy (RP) or brachytherapy (BT) more effective treatment for PCa. This study presents first highly comprehensive and up-to-date comparative analysis overall outcomes RP versus BT.We conducted systematic literature search studies published on PubMed, EMBASE, Cochrane Library BT in clinically localized The cumulative was performed using Review Manager Version 5.3...
Background Ferroptosis has been proven to contribute the progression of myocardial ischemia/reperfusion (I/R) injury and can be inhibited or promoted by ATF3. Short-chain fatty acids (SCFAs) have shown benefits in various cardiovascular diseases with anti-inflammatory antioxidant effects. However, impact SCFAs on ferroptosis ischemic-stimulated cardiomyocytes remains unknown. This study aimed investigate effect cardiomyocyte ferroptosis, expression ATF3, its potential upstream regulators....