A5101567732- Mesenchymal stem cell research
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Signaling Pathways in Disease
- Cardiovascular Effects of Exercise
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Disease and Adiposity
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Nitric Oxide and Endothelin Effects
- Monetary Policy and Economic Impact
- Pain Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- PARP inhibition in cancer therapy
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
- Hereditary Neurological Disorders
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Wound Healing and Treatments
Xijing Hospital
2015-2025
Second Military Medical University
2016-2025
Air Force Medical University
2015-2025
Guangxi University of Chinese Medicine
2023
Shenzhen Institute of Information Technology
2022
Harbin Institute of Technology
2021-2022
Nanjing Audit University
2020-2022
Institute of Economics
2020-2022
Xi'an Physical Education University
2022
Huazhong University of Science and Technology
2019
Objective— Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest systemic dysfunction unless metabolically challenged. The protein family CTRPs (C1q/TNF-related proteins) has recently been identified as paralogs and some CTRP members share APN′s metabolic regulatory function. the vasoactive properties of remain completely unknown. Methods Results— vasoactivity currently murine was assessed aortic...
Abstract Melatonin confers cardioprotective effect against myocardial ischemia/reperfusion ( MI / R ) injury by reducing oxidative stress. Activation of silent information regulator 1 SIRT 1) signaling also reduces injury. We hypothesize that melatonin may protect activating signaling. This study investigated the protective treatment on heart and elucidated its potential mechanisms. Rats were exposed to in presence or absence receptor antagonist luzindole inhibitor EX 527 then subjected...
Background— Obesity and diabetes mellitus adversely affect postischemic heart remodeling via incompletely understood mechanisms. C1q/tumor necrosis factor–related protein-3 (CTRP3) is a newly identified adipokine exerting beneficial metabolic regulation, similar to adiponectin. The aim of the present study was determine whether CTRP3 may regulate cardiac dysfunction, and, if so, elucidate underlying Methods Results— Male adult mice were subjected myocardial infarction (MI) left anterior...
Background— C1q/tumor necrosis factor–related protein-9 (CTRP9) is a newly identified adiponectin paralog with established metabolic regulatory properties. However, the role of CTRP9 in postmyocardial infarction remodeling remains completely unknown. This study determined whether may regulate cardiac after acute myocardial (AMI) and elucidated underlying mechanisms. Methods Results— Male adult mice were subject to AMI by left anterior descending coronary artery ligation or sham surgery...
Wound dressings composed of natural polymers, such as type I collagen, possess good biocompatibility, water holding capacity, air permeability, and degradability, can be used in wound repair. However, due to the persistent oxidative stress area, migration proliferation fibroblasts might suppressed, leading poor healing. Thus, collagen-containing scaffolds are not suitable for accelerated Antioxidant N-acetyl cysteine (NAC) is known reduce reactive oxygen species (ROS) has been widely clinic....
Exercise benefits to cardiac rehabilitation (CR) following stable myocardial infarction (MI). The suitable exercise duration for aged patients with coronary heart disease (CHD) remains controversial, and the underlying molecular mechanism is still unclear.18-Month-old mice after MI were randomly submitted different durations of exercise, including 15 60 min swimming training (ST) once per day, five times a week 8 weeks. Compared sedentary mice, ST, rather than significantly augmented left...
Abstract Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, biological cardiac-derived CTRP9 remains unclear. We hypothesize responds ischemia/reperfusion (MI/R) injury as cardiokine. explored MI/R via genetic manipulation CTRP9-knockout (CTRP9-KO) animal model. Inhibition exacerbated, whereas its overexpression...
Abstract C1q-tumor necrosis factor-related protein-3 (CTRP3) is an adipokine, which exerts protective function in ischemic or diabetic heart injury. However, the role of CTRP3 cardiac hypertrophy remains unclear. The aim this study was to investigate pharmacological effects on pathological induced by hypertension. Male C57BL/6 J wild-type (WT) mice, Ctrp3 knockout and mice infected with lentivirus overexpressing mouse underwent sham surgery transverse aortic constriction (TAC) surgery. After...
The relationship between the Charlson comorbidity index (CCI) and short-term readmission is as yet unknown. Therefore, we aimed to investigate whether CCI was independently related in patients with heart failure (HF) after adjusting for other covariates. From December 2016 June 2019, 2008 who underwent HF were enrolled study determine readmission. Patients divided into 2 categories based on predefined (low < 3 high > =3). relationships analyzed multivariable logistic regression models a...
Diabetes exacerbates ischemic heart disease morbidity and mortality via incompletely understood mechanisms. Although adiponectin (APN) reduces myocardial ischemia/reperfusion (MI/R) injury in nondiabetic animals, whether APN's cardioprotective actions are altered diabetes, a pathologic condition with endogenously reduced APN, has never been investigated. High-fat diet (HD)-induced diabetic mice normal (ND) controls were subjected to MI coronary artery ligation, given vehicle or APN globular...
Abstract Tissue‐engineered heart valves ( TEHV s) are a promising treatment for valvular disease, although their application is limited by high flow shear stress FSS ). Melatonin has wide range of physiological functions and currently under clinical investigation expanded applications; moreover, extensive protective effects on the cardiovascular system have been reported. In this study, we investigated protection conferred melatonin supplementation against ‐induced injury in bone marrow...
Prevalence and severity of postmyocardial infarction heart failure continually escalate in type 2 diabetes via incompletely understood mechanisms. The discovery the cardiac secretomes, collectively known as "cardiokines", has significantly enhanced appreciation local microenvironment's influence on disease development. Recent studies demonstrated that C1q-TNF-related protein-9 (CTRP9), a newly discovered adiponectin (APN) paralog, is highly expressed heart. However, its relationship with APN...
Mitochondrial unfolding protein response (UPRmt) effectively resists the pathological cardiac hypertrophy and improves mitochondrial function. However, specific activation mechanism drugs that can activate UPRmt in muscle are yet to be elucidated. The aim of this study was determine regulation role on preventing by tetrahydrocurcumin (THC) explore its underlying molecular mechanism. Male C57BL/6J wild-type (WT) mice were divided into a control group subjected sham treatment for 4 weeks, test...
Abstract Mesenchymal stromal cells (MSCs) transplantation offers an attractive alternative in myocardial infarctive therapy. However, poor cell engraftment and survival limit their restorative capacity. C1q/tumor necrosis factor-related protein-3 (CTRP3) inhibits reverse remodeling after infarction (MI) was found to be secreted by MSCs our preliminary experiments. We examined whether the overexpression of CTRP3 improved transplanted augmented efficacy on MI silencing attenuated these...