A5104688161- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Neonatal Respiratory Health Research
- Antioxidant Activity and Oxidative Stress
- Regulation of Appetite and Obesity
- Chronic Kidney Disease and Diabetes
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Neuropeptides and Animal Physiology
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Chronic Lymphocytic Leukemia Research
- Alcohol Consumption and Health Effects
- Thyroid Cancer Diagnosis and Treatment
- Advanced Glycation End Products research
- Plant Stress Responses and Tolerance
- Diet and metabolism studies
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Cholesterol and Lipid Metabolism
- Trace Elements in Health
Bengbu Medical College
2025
Jilin Agricultural University
2023-2025
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Hangzhou Hospital of Traditional Chinese Medicine
2025
Southeast University
2025
Shanghai First Maternity and Infant Hospital
2024
Jinhua Academy of Agricultural Sciences
2016-2024
Anhui Medical University
2008-2024
Kunming Medical University
2021-2024
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues therapy are lacking. Here we present a "Cardiopatch" platform 3D culture maturation hiPSC-CMs that after 5 weeks differentiation show robust electromechanical coupling, consistent H-zones, I-bands, evidence T-tubules M-bands. Cardiopatch markers output increase during culture, approaching values...
Ceramides in focus Excess calorie intake can ultimately lead to a metabolic syndrome that interferes with fat or lipid metabolism. There are many different types of lipids, and it has been widely debated which the true culprits underlying disorders. Chaurasia et al. report ceramides major contributor insulin resistance fatty liver disease (see Perspective by Kusminski Scherer). This appears be caused enzyme dihydroceramide desaturase 1 (DES1), is normally involved ceramide production...
The generation of functional skeletal muscle tissues from human pluripotent stem cells (hPSCs) has not been reported. Here, we derive induced myogenic progenitor (iMPCs) via transient overexpression Pax7 in paraxial mesoderm differentiated hPSCs. In 2D culture, iMPCs readily differentiate into spontaneously contracting multinucleated myotubes and a pool satellite-like endogenously expressing Pax7. Under optimized 3D culture conditions, derived multiple hPSC lines reproducibly form (iSKM...
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes. Despite three decades investigation, the biological roles AMPK and its potential as drug target remain incompletely understood, largely because lack optimized pharmacological tools. We developed MK-8722, potent, direct, allosteric activator all 12 mammalian complexes. In rodents rhesus monkeys, MK-8722-mediated activation skeletal muscle induced robust, durable,...
Mechanisms of brain and retinal iron homeostasis have become subjects increased interest after the discovery elevated levels in brains patients with Alzheimer's disease retinas age-related macular degeneration. To determine whether ferroxidase ceruloplasmin (Cp) its homolog hephaestin (Heph) are important for homeostasis, we studied from mice deficient Cp and/or Heph. In normal mice, Heph localize to Müller glia pigment epithelium, a blood-brain barrier. Mice both Heph, but not each...
Background/Aims: Ecological studies have shown that air pollution and prevalence of cigarette smoking are positively correlated. Evidence also suggests a synergistic effect PM2.5 exposure (Environmental Particulate Matter ≤ 2.5 µm in diameter) on lung cancer risk. We aimed to evaluate the interaction between relation mortality determine its underlying mechanisms vitro. Methods: “MOVER” method was used analyze mortality. Cell autophagy malignant behaviors induced by smoke extract (CSE) were...
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by abnormal steroid hormone levels in peripheral blood and poor-quality oocytes. In the ovary, androgen produced theca cells, estrogen granulosa cells. Androgen converted to with cytochrome P450 aromatase as limiting enzyme during this process. Estrogen receptors (ER) include ER alpha, beta, membrane receptor GPR30. Studies have demonstrated that functions of its estradiol synthesis-related enzymes are closely related...
Neuromedin U (NMU) and neuromedin S (NMS) are structurally related neuropeptides that have been reported to modulate energy homeostasis. Pharmacological data shown NMU NMS inhibit food intake when administered centrally increases expenditure. Additionally, NMU-deficient mice develop obesity, whereas transgenic overexpressing lean hypophagic. Two high-affinity NMU/NMS receptors, NMUR1 NMUR2, identified. is predominantly expressed in the periphery, NMUR2 brain, suggesting effects of mediated...
Neuromedin U (NMU) is a highly conserved peptide reported to modulate energy homeostasis. Pharmacological studies have shown that centrally administered NMU inhibits food intake, reduces body weight, and increases expenditure. NMU-deficient mice develop obesity, whereas transgenic overexpressing become lean hypophagic. Two high-affinity receptors, NMUR1 NMUR2, been identified. found primarily in the periphery NMUR2 brain, where it mediates anorectic effects of NMU. Given broad expression...
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose energy homeostasis. potentiates glucose-dependent insulin secretion demonstrated clinical studies robust lowering type 2 diabetes. improves sensitivity rodents, albeit its mechanism of action is not fully understood. Here, we postulated the antidiabetic efficacy could be enhanced by coactivating GPR120. A combination agonists db/db mice, as well a single molecule with dual agonist activities, achieved superior...
Overactive lipolysis in adipose tissue contributes to the pathogenesis of alcoholic liver disease (ALD); however, mechanisms involved have not been elucidated. We previously reported that chronic alcohol consumption produces a hypomethylation state tissue. In this study we investigated role alcohol-induced and whether its correction well-established hepatoprotective effect betaine ALD.Male C57BL/6 mice were divided into four groups started on one treatments for 5 weeks: isocaloric pair-fed...
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intracellular NAD+ levels are tightly regulated often respond rapidly to nutritional environmental changes. Numerous studies indicate that elevating may be therapeutically beneficial in the context of numerous diseases. However, role on skeletal muscle...
Abstract Ginsenoside Rh2 (G-Rh2) has well-established potent antitumor activity; yet, the effects of G-Rh2 on immune and metabolism regulation in cancer treatment, especially non-small cell lung (NSCLC) remain unclear. We showed that had a synergistic effect with cyclophosphamide (CY) mice NSCLC, improved deficiency caused by CY. Consistently, exhibited no inhibitory tumor growth T cells-deficient nude mice. Furthermore, treatment triggered oxidative decomposition fatty acid (FA), suppressed...
Abstract Early embryonic arrest is one of the major causes recurrent assisted reproduction failure. It characterized by delayed development and failure to form viable eight‐cell stage embryos on day 3 an cycle. A recent study reported that biallelic mutations in NLRP5 can cause early arrest. a member subcortical maternal complex, which plays significant role embryogenesis. In this study, we described female consanguineous Chinese family who displayed clinical features identified novel...
We investigated the ambulatory blood pressure in rural Chinese and compared its characteristics with those reported other population-based studies. enrolled inhabitants from 6 villages of JingNing County, China. recorded 90207 SpaceLabs monitors. Trained observers measured conventional at participants' homes. The 356 participants (12–86 years) included 192 (53.9%) women 117 (32.9%) hypertensive patients. In all participants, systolic/diastolic averaged 129/80 mm Hg home. means were 121/77...
Dangguiliuhuang decoction (DGLHD) has been demonstrated to be effective in treating inflammatory, hepatic steatosis, and insulin resistance. In the study, we tried elucidate pharmacological efficacy mechanism of DGLHD against liver fibrosis predicate potential active ingredients targets via network analysis experimental validation. formula, totally discovered 76 like baicalein, berberine, wogonin, 286 corresponding including PTGS (prostaglandin-endoperoxide synthase) 2, PPAR (peroxisome...
Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying to render glucose-responsive release from an injection depot (of complexed exogenously a recombinant lectin) was proposed approximately 4 decades ago but has been challenging achieve. Data presented here demonstrate that mannosylated analogs can undergo additional route clearance as result their interaction endogenous mannose receptor (MR), this occur in glucose-dependent...
Background To investigate the association between gestational diabetes mellitus (GDM) without subsequent overt and long-term all-cause cardiac mortality. Methods This prospective cohort study included 10,327 women (weighted population: 132,332,187) with a pregnancy history from National Health Nutrition Examination Survey (2007 to 2018). Participants were divided into three groups (GDM alone, diabetes, no diabetes). Mortality data was linked Death Index up December 31, 2019. Multivariable...