A5036614817- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- 3D Printing in Biomedical Research
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Geochemistry and Geologic Mapping
- Coronary Interventions and Diagnostics
- Microbial Fuel Cells and Bioremediation
- Additive Manufacturing and 3D Printing Technologies
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Anaerobic Digestion and Biogas Production
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Polymer composites and self-healing
- Biofuel production and bioconversion
- Atrial Fibrillation Management and Outcomes
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2015-2025
Hangzhou Hospital of Traditional Chinese Medicine
2022-2024
Nanjing University of Chinese Medicine
2024
Ningxia Medical University
2020-2024
Shenzhen Second People's Hospital
2024
Bureau of Geology and Mineral Exploration and Development of Guizhou Province
2022-2023
University of Maryland, College Park
2023
East China Jiaotong University
2023
Chongqing University
2022
The unique properties of self-healing materials hold great potential in the field biomedical engineering. Although previous studies have focused on design and synthesis materials, their application vivo settings remains limited. Here, we a series biodegradable biocompatible elastomers (SHEs) with tunable mechanical properties, apply them to various disease models vivo, order test reparative multiple tissues at physiological conditions. We validate effectiveness SHEs as promising therapies...
Three-dimensional (3D) printing thermosets offers great potential to customize sophisticated constructs for a myriad of applications.
Cardiovascular disorders are still the primary cause of mortality worldwide. Although intramyocardial injection can effectively deliver agents to myocardium, this approach is limited because its restriction needle-mediated and minor retention in myocardium. Here, we engineered phase-transition microneedles (MNs) coated with adeno-associated virus (AAV) achieved homogeneous distribution AAV delivery. Bioluminescence imaging revealed successful delivery transfection AAV-luciferase. AAV-green...
A simple strategy tailors perfusable and permeable hierarchical microchannel networks from diverse materials.
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets through-pores. The mesoscale interconnected pore architectures governed the relative alignment layers shown to direct cell and muscle-like fiber orientation in both skeletal cardiac muscle, enabling scale up tissue constructs towards clinically relevant dimensions. As a service our authors readers, this journal provides supporting information...
Myocardial remodeling, including ventricular dilation and wall thinning, is an important pathological process caused by myocardial infarction (MI). To intervene in this process, a new type of cardiac scaffold composed thermoset (poly-[glycerol sebacate], PGS) thermoplastic (poly-[ε-caprolactone], PCL) directly printed employing fused deposition modeling 3D-printing technology. The PGS-PCL possesses stacked construction with regular crisscrossed filaments interconnected micropores exhibits...
Cardiovascular diseases such as myocardial infarction (MI) are among the major causes of death worldwide. Although intramyocardial injection hydrogels can effectively enhance ventricular wall, this approach is limited because its restriction to poor vascularization in infarcted myocardium. Here, we reported a new type hydrogel composed alginate (ALG) and hyaluronic acid (HA) with lyophilized platelet-rich fibrin (Ly-PRF) for releasing abundant growth factors realize their respective...
The sequestration of nanoparticles by mononuclear phagocyte system is a challenge for the use nanotherapy treating cardiovascular diseases due to conventionally perceived loss therapeutic potency. Here, we revitalize unlocking an alternative route in which nanomedicines are redirected spleen, leveraging its potential as highly efficient and targeted site remote conditioning, or tele-conditioning myocardial reperfusion injury. theoretical foundation underpinning splenogenic nature recruited...
BACKGROUND: The optimal antispastic treatment after coronary artery bypass grafting using radial (RA) grafts is controversial. This clinical trial aimed to generate pilot comparative data on the effects of nicorandil, isosorbide mononitrate, or diltiazem RA grafts. METHODS: was a single-center, randomized, open-label, parallel-group trial. Eligible patients who underwent were randomized in 1:1:1 ratio receive oral nicorandil (15 mg daily), mononitrate (50 (180 daily) for 24 weeks...
Implanted medical biomaterials are closely in contact with host biological systems via biomaterial–cell/tissue interactions, and these interactions play pivotal roles regulating cell functions tissue regeneration. However, many degrade over time, degradation products also have been shown to interact cells/tissue. Therefore, it may prove useful specifically design implanted which greatly improve the performance of implant. Herein, we report an injectable, citrate-containing polyester hydrogel...
Abstract Elastomers are essential for stretchable electronics, which have become more and important in bio-integrated devices. To ensure high compliance with the application environment, elastomers expected to resist, even self-repair, mechanical damage, while being friendly human body. Herein, inspired by peptidoglycan, we designed first room-temperature autonomous self-healing biodegradable biocompatible elastomers, poly(sebacoyl 1,6-hexamethylenedicarbamate diglyceride) (PSeHCD)...
Abstract GPRC5A is a G-protein–coupled receptor expressed in lung tissue but repressed most human cancers. Studies Gprc5a−/− mice have established its role as tumor-suppressor function this setting, the basis for has been obscure. Here, we report that functions negative modulator of EGFR signaling. Mouse tracheal epithelial cells (MTEC) from exhibited relative increase and downstream STAT3 signaling, whereas expression inhibited physically interacted with through transmembrane domain, which...
The rapid popularization of advanced metering infrastructure (AMI) smart meters produces customer high-frequency energy consumption data. These data provide diverse options for economics and policy research. In this review, we examine studies applying high frequency meter to explore the overall impact household new technology adoption COVID-19 on patterns. We find that boosts accuracy forecasting models with various data-driven algorithms. addition, there is a lack precise assessment...
The application of polyelectrolyte multilayer films is a new, versatile approach to surface modification decellularized tissue, which has the potential greatly enhance functionality engineered tissue constructs derived from organs. In present study, we test hypothesis that Heparin- vascular endothelial growth factor (VEGF) film can not only act as an antithrombotic coating reagent, but also induce proliferation progenitor cells (EPCs) on aortic heart valve. SEM demonstrated adhesion and...
Fibrotic diseases remain a substantial health burden with few therapeutic approaches. A hallmark of fibrosis is the aberrant activation and accumulation myofibroblasts, which caused by excessive profibrotic cytokines. Conventional anticytokine therapies fail to undergo clinical trials, as simply blocking single or several antifibrotic cytokines cannot abrogate microenvironment. Here, biomimetic nanoparticles based on autologous skin fibroblasts are customized decoys neutralize multiple...