A5044621476- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Inflammatory mediators and NSAID effects
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Neuropeptides and Animal Physiology
- Inflammatory Biomarkers in Disease Prognosis
- Asphalt Pavement Performance Evaluation
- Hormonal Regulation and Hypertension
- Aortic aneurysm repair treatments
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Parathyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Chemokine receptors and signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Osteoarthritis Treatment and Mechanisms
- Sepsis Diagnosis and Treatment
- Robotics and Automated Systems
- Tryptophan and brain disorders
- Advanced Surface Polishing Techniques
- Cardiac Fibrosis and Remodeling
- NF-κB Signaling Pathways
Soochow University
2020-2024
Sun Yat-sen University
2023
Shanghai Jiao Tong University
2020-2022
Peking University
2013-2022
XinHua Hospital
2007-2022
Central South University
2009-2022
University of Kentucky
2017-2021
Yueyang Hospital
2021
Shanghai University of Traditional Chinese Medicine
2021
Tongji Hospital
1998-2020
Abstract Background Since December 2019, the outbreak of COVID-19 caused a large number hospital admissions in China. Many patients with have symptoms acute respiratory distress syndrome, even are danger death. This is first study to evaluate dynamic changes D-Dimer and Neutrophil-Lymphocyte Count Ratio (NLR) as prognostic utility for clinical use. Methods In retrospective study, we collected data from 349 hospitalized who diagnosed infection Wuhan Pulmonary Hospital. We used ROC curves Cox...
Although VEGF-B was discovered as a VEGF-A homolog long time ago, the angiogenic effect of remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit together other VEGF family members are being used to treat patients various neovascular diseases. It is therefore critical have better understanding underlying mechanisms. Using comprehensive in vitro vivo methods models, we reveal here for first an unexpected surprising function...
ORIGINAL RESEARCH article Front. Pharmacol., 28 September 2017Sec. Experimental Pharmacology and Drug Discovery Volume 8 - 2017 | https://doi.org/10.3389/fphar.2017.00675
Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibitinhibits phosphorylation RIPK1. RIPK1 regulates inflammation and cell death by interacting with serine/threonine kinases 3(RIPK3). We hypothesised Nec-1 may have anti-inflammatory efficacy in patients osteoarthritis (OA), as the pathophysiology OA involves activation inflammation-related signalling pathways apoptosis. In this study, we explored effects on...
Oxidative stress plays a critical role in the development of abdominal aortic aneurysm (AAA). Intermedin (IMD) is regulator oxidative stress. Here, we investigated whether IMD reduces AAA by inhibiting stress.In angiotensin II-induced ApoE-/- mouse and CaCl2-induced C57BL/6J model AAA, IMD1-53 significantly reduced incidence maximal diameter. Ultrasonography, hematoxylin, eosin staining Verhoeff-van Gieson showed that decreased enlarged aortas elastic lamina degradation induced II or CaCl2....
We evaluated the role of CXCL12/CXCR4 (C-X-C motif chemokine ligand 12/C-X-C receptor type 4) axis in aggrecanase-mediated cartilage degradation, and explored underlying mechanism a post-traumatic osteoarthritis rat model. Expression ADAMTS-5 was analyzed knees osteoarthritic non-arthritic rats using Western blot, ELISA, immunohistochemistry immunofluorescence. Rodent studies were performed Sprague-Dawley rats, with animals divided into three groups: Destabilization medial...
The Wnt/β-catenin signaling is an ancient and evolutionarily conserved pathway that regulates essential aspects of cell differentiation, proliferation, migration polarity. Canonical has also been implicated in the pathogenesis atherosclerosis. Macrophage one major types involved initiation progression atherosclerosis, but role macrophage β-catenin atherosclerosis remains elusive. This study aims to investigate impact expression on functions development.To canonical atherogenesis, we...
Background: COVID-19 has been quickly spreading, making it a serious public health threat. It is important to identify phenotypes predict the severity of disease and design an individualized treatment. Methods: We collected data from 213 patients in Wuhan Pulmonary Hospital January 1 March 30, 2020. Principal component analysis (PCA) cluster were used classify patients. Results: identified three distinct subgroups COVID-19. Cluster was largest group (52.6%) characterized by oldest age,...
This study aims to evaluate the treatment effects of physical exercise on menopausal symptoms in middle-aged female medical staff experiencing perimenopausal syndrome.A total 157 aged 40 55 years and with a Kupperman index score 15 points or higher were randomized 1:1 into an intervention group (n = 78) control 79). Women asked perform aerobic (walking strides) three times week more, whereas those continued as normal. Measurements taken at baseline weeks 4, 8, 12, score, scores individual...
Abstract Atherosclerotic plaque vulnerability and rupture increase the risk of acute coronary syndromes. Advanced lesion macrophage apoptosis plays important role in atherosclerotic plaque, endoplasmic reticulum stress (ERS) has been proved to be a key mechanism apoptosis. Intermedin (IMD) is regulator ERS. Here, we investigated whether IMD enhances stability by inhibiting ERS-CHOP-mediated subsequent inflammasome macrophages. We studied effects on features hyperlipemia apolipoprotein...
Endoplasmic reticulum stress (ERS) and inflammation participate in cardiac fibrosis. Importantly, a novel paracrine/autocrine peptide intermedin1-53 (IMD1-53) the heart inhibits myocardial fibrosis rats. However, mechanisms are yet to be fully elucidated.Myocardial apolipoprotein E-deficient (ApoE -/-) mice neonatal rat fibroblasts (CFs) were induced using homocysteine (Hcy).IMD1-53 inhibited vivo vitro. Picrosirius red staining showed that IMD1-53 reduced interstitial collagen deposition...
Abstract Background Since December 2019, the outbreak of COVID-19 caused a large number hospital admissions in China. Many patients with have symptoms acute respiratory distress syndrome, even are danger death. This is first study to evaluate dynamic changes D-Dimer and Neutrophil-Lymphocyte Count Ratio (NLR) as prognostic utility for clinical use. Methods In retrospective study, we collected data from 349 hospitalized who diagnosed infection Wuhan Pulmonary Hospital. We used ROC curves Cox...
Objective: Intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide family, is involved in maintaining circulatory homeostasis and protective factor heart vessel. Here, we investigated effects IMD on cardiac hypertrophy vivo vitro explored mechanisms involved. Methods results: IMD1–53 (100 ng/kg/h) was systemically administered to rats with induced by abdominal aortic constriction (AAC) mini-osmotic pump next day after surgery continuously for 4 weeks. The...
The pregnane X receptor (PXR) is a nuclear that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as sensor to coordinately regulate host responses xenobiotics transcriptionally regulating many genes involved in metabolism. We have previously reported has pro-atherogenic effects animal models, but how contributes atherosclerosis development different tissues or cell types remains elusive. In this study, we generated an LDL receptor-deficient mouse model with...
The Notch1-mediated inflammatory response participates in the development of abdominal aortic aneurysm (AAA). vascular endogenous bioactive peptide intermedin (IMD) plays an important role maintaining homeostasis. However, whether IMD inhibits AAA by inhibiting inflammation is unclear. In this study, we found Notch intracellular domain (NICD) and hes1 expression were higher patients' aortas than healthy controls. angiotensin II (AngII)-induced mouse model, treatment significantly reduced...