A5102901052- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Fossil Insects in Amber
- Ovarian cancer diagnosis and treatment
- Amphibian and Reptile Biology
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Tissue Engineering and Regenerative Medicine
- Cancer Diagnosis and Treatment
- Heat shock proteins research
- Uterine Myomas and Treatments
- Healthcare and Venom Research
- Environmental and Agricultural Sciences
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Phagocytosis and Immune Regulation
- Telomeres, Telomerase, and Senescence
- PARP inhibition in cancer therapy
Chinese PLA General Hospital
2006-2024
University Health Network
2021
Princess Margaret Cancer Centre
2021
Tongji University
2014-2020
Tongji Hospital
2014-2020
Fudan University
2001-2020
The 309th Hospital of Chinese People's Liberation Army
2018
Center for Disease Control
2017
Huadong Hospital
2014
People's Liberation Army No. 150 Hospital
2014
468214 Background: KRAS G12C mutation occurs in approximately 4% of non-small cell lung cancers (NSCLC) China. Glecirasib (Jacobio, Beijing, PRC) is a potent and highly selective covalent oral inhibitor G12C. Methods: This phase 2 single-arm study (NCT05009329) glecirasib was conducted China at 43 sites, enrolling participants with locally advanced or metastatic mutated NSCLC. Subjects must have received prior platinum-based therapy an immune checkpoint (ICI) as well appropriate targeted...
RRAD (Ras-related associated with diabetes) is a small Ras-related GTPase that frequently inactivated by DNA methylation of the CpG island in its promoter region cancer tissues. However, role methylation-induced inactivation tumorigenesis remains unclear. In this study, Ras-regulated transcriptome and epigenome were profiled comparing T29H (a RasV12-transformed human ovarian epithelial cell line) T29 (an immortalized but non-transformed through reduced representation bisulfite sequencing...
The existence of only natural brown and green cotton fibers (BCF GCF, respectively), as well poor fiber quality, limits the use naturally colored ( Gossypium hirsutum L.). A better understanding pigment regulation is needed to surmount these obstacles. In this work, transcriptome analysis quantitative reverse transcription PCR revealed that 13 9 phenylpropanoid (metabolic) pathway genes were enriched during synthesis, while differential expression flavonoid metabolic occurred among BCF,...
Disulfide bonds play an important role in protein folding. A precise prediction of disulfide connectivity can strongly reduce the conformational search space and increase accuracy structure prediction. Conventional predictions use sequence information, is limited. Here, by using alternative scheme with global information for prediction, higher performance obtained respect to other approaches.Cysteine separation profiles have been used predict proteins. The separations among oxidized cysteine...
Abstract Background Surgery is the primary treatment that can offer potential cure for gastric cancer, but associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, aim this study was to develop a core outcome set (COS)—a standardized group important key international stakeholders—that reported by future in...
As a transforming growth factor-β (TGF-β)-inducible gene, the expression of Krüppel-like transcription factor 11 (KLF11) is altered in several types cancer. In current study, through using human 9K CpG island array, KLF11 was identified as one hypermethylated genes RAS-transformed ovarian T29H cells. Methylation promoter also observed cancer tissue samples accompanied by significantly reduced gene expression. Interestingly, SMAD2, SMAD3, and SMAD7 tumour, whilst no change found TGF-β Our...
This study is to investigate the methylation status of multiple tumor suppressor 1 (p16), secreted glycoprotein 2 (SLIT2), scavenger receptor class A, member 5 putative (SCARA5), and human runt-related transcription factor 3 (Runx3) genes in peripheral blood hepatocellular carcinoma (HCC).This a case-control study. The samples were collected from 25 HCC patients, patients with high risk (defined as "internal control group"), healthy individuals "external respectively. Then p16, SLIT2,...
The underlying physiological mechanisms associated with aging are still complex and unclear. As a very important tissue of human body, the circulatory system also plays role in process aging. In this study, we use isobaric tags for relative absolute quantification (iTRAQ) method to identify differentially expressed proteins plasma humans monkeys between young aged. Western blotting behavioral experiment mice were performed validate expression candidate protein.Between / old 74 69 found be...
We compared the efficacy, safety, and immunogenicity of MIL60 with reference bevacizumab as first-line treatment in patients advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) this phase 3, randomized, double-blind study.Patients untreated NSCLC were randomized (1:1 ratio) to receive either combination paclitaxel/carboplatin. Patients non-progressive disease continued maintenance single-agent until progression, intolerable toxicity. The primary endpoint was 12-week...
To investigate the expressions of key markers in homologous recombination (HR) pathway and correlation with clinicopathological parameters serous ovarian cancer (SOC). We analyzed protein expression MRE11, MDC1, ATM, ATR BRCA1 by immunohistochemistry (IHC) 97 SOC samples, correlated clinical including age, tumor grades, stage, status menstruation chemotherapy. Low MRE11 MDC1 was detected 14.4 % 3.1 patient negative found 11.3 %, 6.3 29.9 respectively. deficiency significantly associated...
Abstract AXL is over-expressed in various cancers. Its signaling pathway related to tumor progress. We created a novel AXL-ADC (Hu002-MMAE) based on humanized AXL-targeted antibody (Hu002). also developed anti-AXL CAR T cells and AXL-CAR iNKT evaluate anti-tumor effect. Methods: 1) Evaluate the cytotoxicity of Hu002-MMAE 5 AXL-high-expressing cells. 2) vivo efficacy validation into LCLC-103H-bearing Nude mice U87MG-bearing nude mice. 3) CAR-T CAR-iNKT cell lines with different expression...
Background: The research was to compare the efficacy and side effects of cisplatin or lobaplatin in combination with mitomycine (MMC) vincristine treating patients cervical squamous carcinoma. Materials Methods: Cervical carcinoma who were pathologically diagnosed stage Ib-IIb from April 2012 May 2013 general hospital Chinese People's Libration Amy enrolled. All confirmed without prior treatment randomly divided into two groups, Group A B. Efficacy evaluated after one cycle chemotherapy....
Objective This retrospective study investigated the effects of uterine manipulator use during minimally invasive radical hysterectomy on prognosis in patients with cervical cancer. Methods We collected clinical data 762 stage IA2 to IIB cancer who underwent and pelvic lymphadenectomy Chinese PLA General Hospital from 2009 2019. Kaplan–Meier analysis log-rank tests were used compare 5-year overall survival rates between treated without a manipulator. Results Patient demographics did not...
e16180 Background: Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited treatment options. The emerging field of tumor immunotherapy, primarily focusing on CD8 + T cells and the microenvironment (TME), has garnered substantial attention. CD4 cells, other hand, play a crucial role in maintaining immune equilibrium orchestrating responses through interactions various cell types. As participants coordinators innate adaptive responses, development remain further exploration....