A5101738196- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Peripheral Nerve Disorders
- Reconstructive Facial Surgery Techniques
- Nerve Injury and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Cancer, Lipids, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Surgical Sutures and Adhesives
- Immunodeficiency and Autoimmune Disorders
- Breast Implant and Reconstruction
- Gastric Cancer Management and Outcomes
- Knee injuries and reconstruction techniques
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Hedgehog Signaling Pathway Studies
- Plant and Fungal Interactions Research
- Colorectal Cancer Surgical Treatments
- Complement system in diseases
- Plant Disease Resistance and Genetics
Centre Hospitalier Régional Universitaire de Brest
2015-2025
Hôpital Maison Blanche
2004-2025
Renmin Hospital of Wuhan University
2013-2025
Ruijin Hospital
2018-2025
Shanghai Jiao Tong University
2011-2025
Wuhan University
2013-2025
Université de Bretagne Occidentale
2020-2024
Obstetrics and Gynecology Hospital of Fudan University
2013-2023
Changsha University of Science and Technology
2023
Brigham and Women's Hospital
2023
During the previous cloning of fibrillin gene (FBN1), we isolated a partial cDNA coding for fibrillin-like peptide and mapped corresponding (FBN2) to human chromosome 5. (Lee, B., M. Godfrey, E. Vitale, H. Hori, G. Mattei, Sarfarazi, P. Tsipouras, F. Ramirez, D. W. Hollister. 1991. Nature [Lond.]. 352:330-334). The study left, however, unresolved whether or not FBN2 product is an extracellular component structurally related fibrillin. Work presented in this report clarifies important point....
Inflammatory bowel disease (IBD) affects millions of people each year. The overproduction reactive oxygen species (ROS) plays a critical role in the progress IBD and will be potential therapeutic target. Here, we synthesize kind oral zero-valent-molybdenum nanodots (ZVMNs) for treatment by scavenging ROS. These ultrasmall ZVMNs can successfully pass through gastric acid then absorbed intestine. It has been verified that down-regulate quantity ROS reduce colitis mouse model without distinct...
Extracellular microfibrils, alone or in association with elastin, confer critical biomechanical properties on a variety of connective tissues. Little is known about the composition microfibrils factors responsible for their spatial organization into tissue-specific macroaggregates. Recent work has revealed existence two structurally related microfibrillar components, termed fibrillin-1 and fibrillin-2. The functional relationships between these glycoproteins them other components elastic...
Abstract INTRODUCTION: ChatGPT, a language model developed by OpenAI, uses 175 billion parameter Transformer architecture for natural processing tasks. This study aimed to compare the knowledge and interpretation ability of ChatGPT with those medical students in China administering Chinese National Medical Licensing Examination (NMLE) both students. METHODS We evaluated performance two years' worth NMLE, which consists four units. At same time, exam results were compared who had studied five...
Stripe rust (Puccinia striiformis f. sp. tritici; Pst) and powdery mildew (Blumeria graminis Bgt) are important diseases of wheat (Triticum aestivum) worldwide. Increasingly evidences suggest that long intergenic ncRNAs (lincRNAs) developmentally regulated play roles in development stress responses plants. However, identification lincRNAs is still limited comparing with functional gene expression. The transcriptome the hexaploid line N9134 inoculated Chinese Pst race CYR31 Bgt E09 at 1, 2, 3...
Mitophagy is the lysosome-dependent degradation of damaged and dysfunctional mitochondria, which closely associated with H2O2-related redox imbalance pathological processes. However, development fast-responding highly sensitive reversible fluorescent probes for monitoring mitochondrial H2O2 dynamics still lacking. Herein, we report a probe (M-HP) that enables real-time imaging imbalance. In vitro studies demonstrated M-HP had rapid response high sensitivity to H2O2/GSH cycle, detection limit...
Abstract The development of efficient therapeutic agents with low side effects for inflammatory bowel disease management is a longstanding challenge. Recently, hydrogen molecule (H 2 ) identified as an emerging spectrum‐wide, effective, and biosafe anti‐inflammatory agent, but intestine‐targeted H delivery still challenging. Here, controlled hydrogen‐releasing microcapsule (MgH @EC@ES) developed by confining abundant MgH microparticles in the hydrophobic network ethyl cellulose (EC) before...
Background: Composite breast augmentation with fat grafting and an implant has become very popular in the past 5 years. This achieves core volume projection of complemented by natural appearance feel fat. However, no study looked at complications reoperation rates this technique. Methods: A retrospective chart review examined all patients who underwent combined use for primary augmentation. Results: The identified 156 between 2007 2013. mean patient age was 31.7 years average body mass index...
Abstract The development and homeostasis of intestinal epithelium are mediated by actively proliferating Lgr5+ stem cells, which possess a remarkable self-renewal differentiation capacity. Recently, our study demonstrated that m6A methylation was essential for the survival colonic cells. Here, we show METTL3 expression is downregulated in colon mucosa ulcerative colitis (UC) patients strongly associated with maturation goblet cells during inflammation. In mice, depletion Mettl3 significantly...
Phalloplasty is one of the most complex procedures in plastic surgery. The criteria for an ideal neophallus include aesthetic and erogenous phallus that allows sexual intercourse, with a functional neo-urethra enabling standing urination. free forearm flap has become gold standard phallic reconstruction. Various modifications have been made to improve vascularization reduce urinary complications, such as fistulas urethral stenosis. Each design its advantages disadvantages, goal minimizing...
ABSTRACT Identifying factors affecting lifespan, including genes or proteins, enables effective interventions. We prioritized potential drug targets and provided insights into biological pathways for healthy longevity by integrating Mendelian randomization, cohort, experimental studies. identified causal effects of tissue‐specific genetic transcripts serum protein levels on three outcomes: the parental top 1% 10% extreme longevity, utilizing randomization multi‐traits colocalization,...
Pancreatic cancer seriously threatens human health. Bee venom is a mixture of enzymes, peptides, and amines. Due to its biological activity, bee widely used as an anti-inflammatory agent pain reliever. However, little known about the effect on pancreatic cancer.Firstly, Cell Counting Kit-8 (CCK-8) assay was conducted analyze cytotoxicity PANC-1 AsPC-1 cells. Then, we evaluated cell cycle apoptosis by flow cytometry terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL)...
Abstract Aims To investigate the effect of Self‐designed Metabolic Equivalent Exercises (SMEE) on cancer‐related fatigue in patients with gastric cancer. Methods 130 cancer admitted to Department Oncology a tertiary hospital Shanghai were enrolled and assessed for eligibility. After excluding 1 patient who declined participate, 129 eligible randomly assigned into SMEE ( n = 65) control 64) groups. The Revised Piper Fatigue Scale (RPFS) EORTC QLQ‐C30 Quality Life used measure cancer‐caused...