A5102853910- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Nuclear Structure and Function
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- RNA regulation and disease
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Medical Imaging and Pathology Studies
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Melanoma and MAPK Pathways
- Glioma Diagnosis and Treatment
Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2016-2025
Memorial Hospital of South Bend
2014-2025
National Cheng Kung University
2009-2024
Weatherford College
2023
Linkou Chang Gung Memorial Hospital
2007-2022
Kaohsiung Chang Gung Memorial Hospital
2007-2021
Leidos Biomedical Research Inc. (United States)
2019
St. Jude Children's Research Hospital
2019
Leidos (United States)
2019
Abstract Tumor immunotherapies targeting PD-(L)1 exhibit anti-tumor efficacy in only 10–30% of patients with various cancers. Literature has demonstrated that a “hot tumor” which contains high T lymphocytes the tumor microenvironment exhibits better response to than “cold tumor.” This study aimed investigate whether tumor-intrinsic IFNα and CXCL10 determine recruitment activation CD8 + cells become In this study, we found overexpressed variety tumors including lung, colon, liver correlation...
The process of nucleocytoplasmic shuttling is mediated by karyopherins. Dysregulated expression karyopherins may trigger oncogenesis through aberrant distribution cargo proteins. Karyopherin subunit alpha-2 (KPNA2) was previously identified as a potential biomarker for nonsmall cell lung cancer integration the secretome and tissue transcriptome data sets. Knockdown KPNA2 suppressed proliferation migration abilities cells. However, precise molecular mechanisms underlying activity in remain to...
Recent evidence from several relatively small nested case‐control studies in prospective cohorts shows an association between longer telomere length measured phenotypically peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere‐length associated genetic variants large study 5,457 never‐smoking female Asian cases 4,493 controls using data previously reported genome‐wide study. Using group...
Lung cancer is the leading cause of cancer-related death worldwide. Both diagnostic and prognostic biomarkers are urgently needed to increase patient survival. In this study, we identified/quantified 1763 proteins from paired adenocarcinoma (ADC) tissues with different extents lymph node (LN) involvement using an iTRAQ-based quantitative proteomic analysis. Based on a bioinformatics analysis literature search, selected six candidates (ERO1L, PABPC4, RCC1, RPS25, NARS, TARS) set 133 that...
Radiotherapy (RT) not only damages tumors but also induces interferon (IFN) expression in tumors. IFNs mediate PD-L1 to exhaust CD8+ T cells, which directly impact tumor cells and potentially activate anti-tumor immune surveillance. Little is known about the contradictory mechanism of regulating T-mediated activity lung cancer. This study found that RT induced CXCL9/10 RT-treated cancer cells. Specifically, RT- IFNγ-pretreated A549 significantly activated resulting significant inhibition...
High disease burden suggests the desirability to identify high-risk Asian never-smoking females (NSF) who may benefit from low-dose CT (LDCT) screening. In North America, one is eligible for LDCT screening if satisfies U.S. Preventive Services Task Force (USPSTF) criteria or has model-estimated 6-year risk greater than 0.0151. According two reports, only 36.6% female patients with lung cancer met USPSTF criteria, while 38% of ever-smokers ages 55 74 years criteria.
Obstructive sleep apnea (OSA) has been associated with increased cancer incidence and mortality. The aim of this study was to investigate cancer-related mortality, overall survival progression free in patients suspected OSA lung cancer.
Nonsmall cell lung cancer (NSCLC) is the most common type of cancer, which one prominent causes cancer-related mortality worldwide. Discovery serum tumor markers could facilitate early NSCLC detection and metastatic prognosis. Here, we simultaneously analyzed secretome proteomic profiles pleural effusion from adenocarcinoma patients for biomarker discovery. Retinoblastoma-associated binding protein 46 (RbAp46), proteins detected both in proteome, was chosen further evaluation. Both RbAp46...
Malignant pleural effusion (MPE) obtained from lung adenocarcinoma may contain potentially useful biomarkers for detection of cancer. In this study, we used a removal system high-abundance proteins followed by one-dimensional SDS-PAGE combined with nano-LC-MS/MS to generate comprehensive MPE proteome data set 482 nonredundant proteins. Next, integrated the and secretome sets three cell lines, view identifying potential PE originating malignant cells. Four candidates, alpha-2-HS-glycoprotein...
Background Treatment for stage III non‐small cell lung cancer (NSCLC) of unresectable disease mainly involves concurrent chemoradiation (CRT). Post‐CRT consolidation treatment with durvalumab is a major therapeutic advance that provides survival benefit in this group patients. However, the performance strategy remains to be studied real‐world setting. Methods A total 31 patients who had control post‐CRT were included early access program (EAP) as an intent‐to‐treat cohort and retrospectively...
Gefitinib, erlotinib and afatinib provide remarkable response rates progression-free survival compared to platinum-based chemotherapy in patients with non-small cell lung cancer harboring epidermal growth factor receptor-activating mutations, are therefore standard first-line treatment these patients. However, no study has drugs regarding survival.We conducted this retrospective at a single medical center Taiwan from February 16, 2011 October 30, 2015. We used the Kaplan-Meier method...
The ability to discriminate lung cancer malignant pleural effusion (LC-MPE) from benign has profound implications for the therapy and prognosis of cancer. Here, we established a pipeline verify potential biomarkers this purpose. In discovery phase, label-free quantification was performed proteome profiling exudative in order select 34 candidate with significantly elevated levels LC-MPE. verification signature peptides candidates were first confirmed by accurate inclusion mass screening...
Abstract Background The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy immune checkpoint inhibitors (ICIs) has not been well established, particularly Asian melanoma. Methods We retrospectively reviewed 49 undergoing ICIs (anti-PD-1 monotherapy), analyzed the correlation irAEs clinical including progression-free (PFS) overall (OS). Results: Overall, who experienced grade 1–2 had longer PFS (median PFS, 4.6...
Neurocognitive functions (NCFs) might change after conventional whole-brain radiotherapy (WBRT). The technique of hippocampus sparing during WBRT (HS-WBRT) may substantially preserve NCFs. Therefore, the aim this study was to examine whether trajectories neuropsychological performances maintained or improved HS-WBRT. A total 125 cancer patients underwent HS-WBRT course. Before HS-WBRT, all participants multidomain neurocognitive assessment, mainly involving executive and hippocampus-related...
The choice of a first-line therapy for lung cancer is crucial decision that can impact the survival as well quality life patient. Inhibitors epidermal growth factor receptor (EGFR) such afatinib, erlotinib, and gefitinib have previously been used to treat non-small cell harboring favorable EGFR mutations. Although afatinib has greater efficacy than other inhibitors, adverse events related its use result in discontinuation therapy. In this study, we compared therapeutic patients regimen 40...
Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy is the primary treatment option for patients with non-small cell lung cancer (NSCLC). However, one of major adverse effects associated this skin toxicity, which impacts patient's quality life. This study aimed to describe severities and locations analyze their association life in advanced NSCLC who received EGFR-TKI as first-line treatment.This cross-sectional correlation was conducted at a tertiary medical center...
Karyopherin alpha 2 (KPNA2) is overexpressed in various human cancers and associated with cancer invasiveness poor prognosis. Herein, to understand the essential role of KPNA2 protein complexes progression, we applied stable isotope labeling amino acids cell culture (SILAC)-based quantitative proteomic strategy combined immunoprecipitation (IP) investigate differential lung adenocarcinoma lines different potentials. We found that 64 KPNA2-interaction proteins displayed a 2-fold difference...
Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and crucial for vesicular trafficking maintaining cell polarity. However, significance of golgin-97 human diseases such as cancer remains unclear. We searched potential role cancers using Kaplan-Meier Plotter ( http://kmplot.com ) Oncomine www.oncomine.org datasets. Specific functions migration invasion were examined golgin-97-knockdown golgin-97-overexpressing cells. cDNA microarray, pathway analysis qPCR used to identify gene...
Background Single agent immune checkpoint inhibitors (ICIs) improve survival outcomes compared to chemotherapy for advanced non‐small cell lung cancer (NSCLC), but treatment efficacy widely varies. The combination of ICIs with has shown promising over alone; however, whether this strategy is superior single the NSCLC remains unknown. Methods records 109 patients who were administered at least one cycle retrospectively reviewed. Patients grouped based on presence or absence a combination....
Introduction Uncommon epidermal growth factor receptor (EGFR) mutations include single and complex mutations. However, the association of smoking status patients with uncommon EGFR remains unclear. Methods This retrospective study evaluates spectrum investigates influence on frequency various using a multi-institutional medical database. Results Between 2010 2019, 5,608 non-small cell lung cancer (NSCLC) were analyzed. detected in 3,155 (56.3%) patients. Among 399 (12.6%) mutations, 198 had...
Abstract Purpose: EGFR tyrosine kinase inhibitors (EGFR-TKI) benefit patients with advanced lung adenocarcinoma (ADC) harboring activating mutations. We aimed to identify biomarkers monitor and predict the progression of receiving EGFR-TKIs via a comprehensive omic analysis. Experimental Design: applied quantitative proteomics generate TKI resistance–associated pleural effusion (PE) proteome from ADC or without EGFR-TKI resistance. Candidates were selected integrated genomic proteomic...
The efficacy of afatinib in combination with bevacizumab untreated advanced epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma is currently unclear. We sought to investigate the this through a multicenter observational analysis. Data for 57 patients EGFR-mutated who received combined as first-line therapy at Chang Gung Memorial Hospitals Linkou and Kaohsiung Taipei Tzu Chi Hospital from May 2015 July 2019 were analyzed. objective response rate disease control 87.7% 100%,...
Abstract Purpose Cutaneous toxicities are common adverse effects following epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) therapy. Zinc deficiency causes diverse diseases, including skin toxicities. Therefore, this study aimed to investigate the role of zinc in patients with EGFR‐TKI‐induced Experimental Design This retrospective enrolled 269 disorders who visited our hospital between January 2016 and December 2017. The toxicity severities plasma levels 101...