A5101625364- Hippo pathway signaling and YAP/TAZ
- Cancer-related Molecular Pathways
- Hedgehog Signaling Pathway Studies
- Wnt/β-catenin signaling in development and cancer
- Iron and Steelmaking Processes
- Renal and related cancers
- Microtubule and mitosis dynamics
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Metallurgical Processes and Thermodynamics
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cardiac Imaging and Diagnostics
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Cancer Genomics and Diagnostics
- Recycling and utilization of industrial and municipal waste in materials production
- Colorectal Cancer Surgical Treatments
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2024-2025
Inner Mongolia University of Science and Technology
2020-2025
Shenzhen University
2022-2024
Northeastern University
2021-2023
Peking Union Medical College Hospital
2019-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Universidad del Noreste
2021-2023
Ministry of Education of the People's Republic of China
2023
Harbin Institute of Technology
2022
Abstract DNA replication is a central procedure of cell proliferation, whereas aberrant indicated to be driving force oncogenesis. Minichromosome maintenance complex component 7 (MCM7) plays an essential role in initiating replication. To investigate the potential oncogenic properties and prognostic value MCM7 hepatocellular carcinoma (HCC), we conducted immunohistochemistry staining 153 HCC samples found that high expression level was associated with worse overall survival (OS) patients....
Significance Breast cancer stem cells (BCSCs) have the property of infinite self-renewal. When these divide, they give rise to one BCSC and transient amplifying cell that can rapidly proliferate but only for a limited number divisions. Only BCSCs secondary (recurrent and/or metastatic) tumors. It is believed breast recurrence due survival small BCSCs. Because represent very minority within primary tumor, their unique characteristics may not be detected by bulk tumor analyses. are often...
Molecular simulations, which can explain macroscopic phenomena from a microscopic molecular perspective, are currently receiving considerable attention. The key to this is how characterize structural parameters and construct realistic numerical models of molecules. In paper, 13C NMR tests were performed on ten coal samples, the macromolecular carbon skeleton structure different samples was calculated analyzed, model constructed modified using Materials Studio (MS). According principles...
Background:The progressive, multifactorial and multistep dynamic process of metastasis is the primary cause breast cancer (BC) lethality.PROX1 (Prospero-related homeobox 1), as a type transcription factor that plays key role in formation lymphatic vessels animal embryonic development, has been proven to promote or suppress variety malignant tumors.However, molecular mechanisms behind PROX1 induced metastases remain elusive.Methods: Changes expression clinical significance BC were evaluated...
SMOC-2 is a novel member of the SPARC family matricellular proteins. The purpose this study was to determine whether can modulate angiogenic growth factor activity and angiogenesis. localized in extracellular periphery cultured human umbilical vein endothelial cells (HUVECs). Ectopically expressed also secreted into tissue culture medium. In microarray profiling experiments, recombinant adenovirus induced expression transcripts required for cell cycle progression HUVECs. Consistent with...
LKB1, also known as STK11, is a master kinase that serves an energy metabolic sensor and involved in cell polarity regulation. Recent studies have indicated LKB1 related to breast tumorigenesis cancer progression. However, little work has been done on the roles of epithelial-mesenchymal transition cancer. In this study, we tried prove loss disrupts epithelial causes tumor metastasis invasion.The relationships expression clinic-pathological parameters markers E-cadherin high-molecular-weight...
Significance Compared with microRNAs (miRNAs) enriched in cardiac and skeletal muscles, little is known about miRNAs expressed early progenitors. Here, we show that mesoderm posterior 1 (Mesp1) transactivates a large number of may promote cardiomyocyte formation. The miR-322/-503 cluster has the highest enrichment Mesp1 lineage progenitor cells, specifically developing heart tube, drives precocious formation by targeting an RNA-binding factor, CUG-binding protein Elav-like family member...
DNA damage induced by the carcinogen benzo[a]pyrene dihydrodiol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint. Here, we have investigated molecular basis of BPDE-induced arrest. inhibition synthesis in BPDE-treated cells occurred without detectable changes Cdc25A levels, Cdk2 activity, or Cdc7/Dbf4 interaction. Overexpression studies showed that Cdc25A, cyclin A/Cdk2, and were not rate-limiting for when checkpoint was active. To investigate other potential targets checkpoint,...
Abstract Drug resistance limits the clinical efficacy of breast cancer therapies, and overexpression or activation Yes‐associated protein (YAP) is common in drug‐resistant cells. Thus, inhibition YAP may reduce to anti‐cancer drugs. Metformin (MET), a first‐line diabetes medication that also has anti‐tumour activities, induces AMP‐activated kinase (AMPK), directly phosphorylates inhibits transcriptional activity. In this study, we determined effect MET on proliferation invasion cells then...
Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency metastasize and resistance chemotherapy. Stem-like tumor cells often confer these aggressive behaviors. We discovered an endoglin (CD105)-expressing subpopulation in human RCC xenografts patient samples with greater capability form spheres vitro tumors mice at low dilutions than parental cells. Knockdown of CD105 by short hairpin RNA CRISPR/cas9 reduced stemness markers sphere-formation ability while accelerating...
The loss of contact inhibition is a hallmark cancer cells. Hippo pathway has recently been shown to be an important regulator inhibition, and the cell apical polarity determinant protein CRB3 suggested involved in signalling. However, whether regulates mammary cells remains unclear, underlying mechanisms have not elucidated. As present study, decreases proliferation, promotes apoptosis, enhances formation tight adherens junctions. Furthermore, we report for first time that acts as upstream...
Pleural effusion (PE), a tumor-proximal body fluid, may be promising source for biomarker discovery in human cancers. Because variety of pathological conditions can lead to PE, characterization the relative PE proteomic profiles from different types PEs would accelerate potential biomarkers specifically used diagnose pulmonary disorders. Using quantitative approaches, we identified 772 nonredundant proteins six exudative PEs, including three malignant (MPE, lung, breast, and gastric...
Renal cell carcinoma (RCC) is one of the common tumors in urinary system without effective therapies. Angiomotin (Amot) can interact with Yes-associated protein (YAP) to either stimulate or inhibit YAP activity, playing a potential role proliferation. However, Amot regulating proliferation renal epithelial and RCC cells unknown. Here, we show that expressed predominantly nucleus tissues, cytoplasm paracancerous tissues. Furthermore, silencing inhibited HK-2 786-O while upregulation promoted...
AbstractDefects in DNA replication are implicated as early and causal events malignancy. However, the immediate effects of impaired licensing on cell cycle progression non-malignant human cells unknown. Therefore, we have investigated acute Mcm7 ablation using synchronized cultures untransformed Human Dermal Fibroblasts (HDF). elicited a G1 delay associated with activation CDK4 CDK2 reduced Rb phosphorylation. The Mcm7-ablated was not damage response. levels cyclin D1 mRNA were specifically...