A5071918408- Cancer, Lipids, and Metabolism
- Freshwater macroinvertebrate diversity and ecology
- Cancer, Hypoxia, and Metabolism
- Fish Ecology and Management Studies
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
- Carbon Nanotubes in Composites
- Nanopore and Nanochannel Transport Studies
- Aquatic Invertebrate Ecology and Behavior
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Polymer crystallization and properties
- Cancer-related Molecular Pathways
- Block Copolymer Self-Assembly
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Developmental Biology and Gene Regulation
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Diatoms and Algae Research
- Graphene research and applications
- Mitochondrial Function and Pathology
- biodegradable polymer synthesis and properties
- Boron and Carbon Nanomaterials Research
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Ningbo University
2021-2024
Xi'an Jiaotong University
2021
The University of Texas Health Science Center at Houston
2021
Tamkang University
2017
Chunghwa Telecom (Taiwan)
2014-2015
National Yang Ming Chiao Tung University
2015
General Hospital of Guangzhou Military Command
2012-2014
Air Force Medical University
2006-2013
National Sun Yat-sen University
2007-2013
Macrophages are important tumor-infiltrating cells and play pivotal roles in tumor growth metastasis. participate immune responses to tumors a polarized manner: classic M1 macrophages produce interleukin (IL) 12 promote tumoricidal responses, whereas M2 IL10 help progression. The mechanisms governing macrophage polarization unclear. Here, we show that the M2-like tumor-associated (TAM) have lower level of Notch pathway activation mouse models. Forced signaling increased which IL12, no matter...
// Jichang Wang 2, 3, * , Guangyue Li 7, Yaochun 1 Shouching Tang 5, 6 Xin Sun 4 Xuefei Feng Yan 3 Gang Bao 2 Pingping Xiaona Mao Maode Peijun Liu Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, P.R.China Department Neurosurgery, Vascular Surgery, Thoracic Surgery and Oncology, China 5 Breast Cancer Program Interdisciplinary Research Team, Georgia Regents University Center, Augusta, Georgia, 30912, United States...
Abstract A sound understanding of the community changes over time and its driving forces is at centre biodiversity conservation ecology research. In this study, we examined: (i) relative roles turnover nestedness components to trait‐ taxonomy‐based temporal beta diversity riverine diatoms; (ii) whether trait‐based provides complementary information diversity; (iii) hydrology (e.g. discharge, antecedent precipitation index), metal ions Mg 2+ , Si ) nutrients nitrogen, orthophosphate) both...
In conventional software-defined networking (SDN), a controller classifies the traffic redirected from switch to determine path network function virtualization (NFV) modules. The redirection generates large volume of control-plane traffic. We propose an extended SDN architecture reduce overhead for providing NFV. extension includes two-layer classification in data plane, OpenFlow protocol messages and service chaining mechanisms. Network events are analyzed plane instead control plane....
Triple Negative Breast cancer (TNBC) is incurable with higher rates of relapse and shorter overall survival compared other subtypes breast cancer. Cellular retinoic acid binding protein 2 (CRABP2) belongs to fatty (FABP) family which binds all-trans (RA). Previous studies from the database have reported patients high expression CRABP2 showed different prognosis in ER+ ER− However, its biological role exact mechanism remain unknown. This aim this study was explore how regulated invasion...
Eosinophils are a myeloid cell subpopulation that mediates type 2 T helper immune responses. Unexpectedly, we identified rapid accumulation of eosinophils in 22 human liver grafts after hepatic transplantation. In contrast, no were detectable healthy tissues before Studies with two genetic mouse models eosinophil deficiency and model antibody-mediated depletion revealed exacerbated injury ischemia reperfusion. Adoptive transfer bone marrow-derived normalized eosinophil-deficient mice reduced...
Cuproptosis is a newly discovered programmed cell death dependent on overload copper-induced mitochondrial respiration dysregulation. The positive response to immunotherapy, one of the most important treatments for invasive breast cancer, depends dynamic balance between tumor cells and infiltrating lymphocytes in microenvironment (TME). However, cuproptosis-related genes (CRGs) clinical prognosis, immune infiltration, immunotherapy remain unclear cancer progression.The expression mutation...
Abstract Discs Large Homolog 5 (DLG5) plays an important role in the maintenance of epithelial cell polarity. Recent research showed that DLG5 is decreased Yes-associated protein (YAP)-overexpressing cells. However, exact relationship between and YAP not clear. In this study, we loss promoted breast cancer proliferation by inhibiting Hippo signaling pathway increasing nuclear expression. Furthermore, depletion induced epithelial-mesenchymal transition (EMT) disrupted polarity, which was...
Abstract Acquired tamoxifen resistance (TamR) remains a major challenge in breast cancer endocrine therapy. The mechanism of acquiring elusive, and no effective drugs are available. In this investigation, we determined that the expression DNA damage marker γH2AX is upregulated under minichromosome maintenance protein 7 (MCM7) knockdown phospho Ser807/811-retinoblastoma (p-Rb) defect cells. addition, p-Rb was lower TamR cells than parental cells, significantly when MCM7 knocked down...
The metacommunity concept has been widely used to explain the biodiversity patterns at various scales. It considers influences of both local (e.g., environmental filtering and biotic interactions) regional processes dispersal limitation) in shaping community structures. Compared spatial processes, influence interactions on streams received limited attention. We investigated relative importance three ecological namely (including geo-climatic factors), (represented by macroinvertebrates...
Dendritic cells (DCs) are professional antigen presenting to initiate immune response against pathogens, but mechanisms controlling the maturation of DCs unclear. Here we report that, in absence recombination signal binding protein-Jkappa (RBP-J, transcription factor mediating Notch signaling), lipopolysaccharide-stimulated monocyte-derived arrested at a developmental stage with few dendrites, low major histocompatibility complex II (MHC II) expression, and reduced motility presentation...
The effect of uni-axial strain on the electronic properties (8,0) zigzag and (5,5) armchair boron nitride nanotubes (BNNT) is addressed by density functional theory calculation. stress-strain profiles indicate that these two BNNTS differing types display very similar mechanical properties, but there are variations in HOMO-LUMO gaps at different strains, indicating BNNTs not only depend strain, BNNT type. nanotube geometries, partial states B N atoms, charges also discussed for strains.
Deformation behaviors of an (8,8) boron-nitride nanotube (BNNT) under axial tensile strains were investigated via molecular dynamics (MD) simulations. The Tersoff potential was employed in the simulations with parameters determined by fitting MD results to those obtained from density functional theory calculations for BNNTs aid force-matching method. Variations stress, bond lengths, angles, radial buckling, and slip vectors strain all examined. axial, radial, tangential components vector...
The loss of contact inhibition is a hallmark cancer cells. Hippo pathway has recently been shown to be an important regulator inhibition, and the cell apical polarity determinant protein CRB3 suggested involved in signalling. However, whether regulates mammary cells remains unclear, underlying mechanisms have not elucidated. As present study, decreases proliferation, promotes apoptosis, enhances formation tight adherens junctions. Furthermore, we report for first time that acts as upstream...
Incorporating functional metrics into the development of a diatom-based index biotic integrity (D-IBI) is conducive to more comprehensive assessment water quality and degree external impact on ecosystem function. A D-IBI was developed by incorporating candidate metrics. Four were selected divided five levels evaluate 147 sampling sites. By comparing scores in Thousand Islands Lake (TIL) catchment, we found that total score ranged from 20 100 (median 45). Compared with reference sites,...
It has been reported that blocking Notch signaling in tumor-bearing mice results abortive angiogenesis and tumor regression. However, given influences numerous cellular processes vivo, a comprehensive evaluation of the effect inactivation on growth would be favorable. In this study, we inoculated four cancer cell lines with conditional recombination signal-binding protein-Jκ (RBP-J), which mediates from all mammalian receptors. We found whereas three tumors including hepatocarcinoma, lung...
The objective of this study was to investigate the main risk factors for poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), allow improvement outcomes through preventive measures.Clinical data 124 patients who received allo-HSCT were analyzed retrospectively.There 83 males (66.9%) and 41 females (33.1%) with a median age 28 years (4-60 years).The follow-up time 7 months (1-116 months).Factors included age, gender, disease diagnosis, source cells,...
Loss or dysfunction of tumor suppressor retinoblastoma (RB) is a common feature in various tumors, and contributes to cancer cell stemness drug resistance therapy. However, the strategy suppress eliminate Rb-deficient cells remains unclear. In present study, we accidentally found that reduction DNA replication licensing factor MCM7 induced more apoptosis RB-deficient than control cells. Moreover, after screening further studies, demonstrated statin Simvastatin Atorvastatin were able inhibit...