A5082211164- Autoimmune Bullous Skin Diseases
- Hypertrophic osteoarthropathy and related conditions
- Dermatological and Skeletal Disorders
- Urticaria and Related Conditions
- Skin and Cellular Biology Research
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Viral-associated cancers and disorders
- Skin Protection and Aging
- Genetic and rare skin diseases.
- Drug-Induced Adverse Reactions
- Mast cells and histamine
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Allergic Rhinitis and Sensitization
- Tuberous Sclerosis Complex Research
- dental development and anomalies
- Hair Growth and Disorders
National Center For Child Health and Development
2013-2025
Nara Medical University
2003-2014
Nara Medical University Hospital
2005
Tokyo Medical Center
1999-2004
Clinical Research Institute
2004
Massachusetts Eye and Ear Infirmary
1997-1999
Smith-Kettlewell Eye Research Institute
1997-1999
Harvard University
1997-1999
Singapore Eye Research Institute
1999
Tokyo National Hospital
1998
BackgroundRecent studies have suggested that epidermal barrier dysfunction contributes to the development of atopic dermatitis (AD) and other allergic diseases.ObjectiveWe performed a prospective, randomized controlled trial investigate whether protecting skin with moisturizer during neonatal period prevents AD sensitization.MethodsAn emulsion-type was applied daily first 32 weeks life 59 118 neonates at high risk for (based on having parent or sibling AD) who were enrolled in this study....
Atopic dermatitis (AD) is characterized by skin barrier dysfunction. Few studies have used noninvasive techniques to measure epidermis function in asymptomatic neonates.Data of 116 infants from our previous randomized controlled study were analyzed. Skin was measured through transepidermal water loss (TEWL), stratum corneum hydration (SCH), and pH. The association between time AD development evaluated. Patients classified with high or low TEWL, SCH pH assessed. survival the hazard ratios...
Since nerve termini on Langerhans cells (LC) contain calcitonin gene-related peptide (CGRP), and since ultraviolet B radiation (UVR) causes CGRP to be released from cutaneous endings, we examined whether participates in the immune aberrations caused skin by UVR. First, intradermally injected CGRP, a dose-dependent manner, reduced LC density impaired CH induction when hapten was painted site. Second, antagonist restored after Third, anti-TNF-alpha Abs before prevented loss of induction....
Pemphigus is a group of autoimmune blistering diseases that affect the skin and mucous membranes. A reliable accurate disease severity tool to assess pemphigus crucial for managing clinical trials. The purpose this study was compare area index activity score (PDAI), Japanese (JPDSS) physician's subjective impression, also find appropriate grading cut-offs PDAI. We evaluated correlation between PDAI JPDSS. Thirty-seven patients 110 assessments were analyzed in study. optimal points were: mild...
<h3>Importance</h3> Most patients with tuberous sclerosis complex (TSC), an autosomal-dominant disorder that is caused by the constitutive activation of mammalian target rapamycin, experience disfigurement skin lesions involving facial angiofibromas. Many have been left untreated because a lack therapeutic options are less invasive than surgery or laser treatment. <h3>Objective</h3> To confirm efficacy and safety sirolimus gel, 0.2%, for treatment angiofibromas and/or lesions. <h3>Design,...
Connexins form the intercellular channels of gap junction and play an integral part in a variety biological functions, such as maintaining tissue homeostasis, cell growth control, development. Previously it was demonstrated that expression connexin 26 (Cx26) can increase metastatic potential mouse melanoma cells. The objective study to investigate role Cx26 plays metastasis human cells, focusing on communication between cells endothelial cells.Immunostaining used examine lesions around...
Abstract Pachydermoperiostosis is a rare hereditary disease, which presents with the cutaneous manifestations of pachydermia and cutis verticis gyrata. Histological findings in frequently include dermal edema, mucin deposition, elastic fiber degeneration, fibrosis adnexal hyperplasia. However, severity these varies between clinical reports, systematic multiple‐case clinicopathological correlative analysis has not been performed to date. In present study, we reviewed skin biopsy specimens...
Abstract Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia. PDP with these three features, along cutis verticis gyrata (CVG), categorized as the “complete form,” whereas cases without CVG are “incomplete form.” The condition linked to elevated levels of systemic prostaglandin E2 (PGE2). About half patients experience arthralgia. standard treatment for selective cyclooxygenase (COX)‐2 inhibitors, but long‐term usage can cause...
Our previous clinical studies have demonstrated the short-term efficacy and safety of sirolimus gel for patients with tuberous sclerosis complex (TSC). However, long-term evidence is lacking. objective was to assess treatment skin lesions TSC patients. We conducted a multicenter, open-label, uncontrolled trial in 94 Japanese TSC. Patients applied 0.2% on their face or head twice daily > 52 weeks (maximum 136 safety). The endpoints were rate adverse event (AE)-caused discontinuation (primary...
Abstract: We performed HLA‐DQA1, ‐DQB1 and ‐DRB1 genotyping using the PCR‐RFLP (polymerase chain reaction‐restriction fragment length polymorphism) method for 32 Japanese pemphigus vulgaris (PV) patients. There was a significant association of either DQB1*0503 or DRB1*1405 with PV, negative DQA1*0103 DQB1*0601 PV found. Since DQB1*0503+ patients had various DR14‐related alleles, we concluded that DQB1 is primary DRB1 simply due to linkage disequilibrium between DQ DR genes. These results may...
Summary Background There have been only limited reports on major histocompatibility complex class I antigens in pemphigus. Objectives To characterize HLA‐A, B and C alleles by genotyping Japanese patients with pemphigus, to analyse the possible association of disease susceptibility within a relatively homogeneous ethnic population. Methods Alleles C, DRB1 DQB1 loci were fully determined 51 Results Asian HLA‐B15 family, including allele B*1507, which was significantly increased comparison...
We present here a 63-year-old man with chronic hepatitis C who developed bullous lesions and anti-intercellular antibodies when he received interferon (IFN) α-2a, 9 MU subcutaneously, 3 times week for months. The direct immunofluorescence was consistent pemphigus features. indirect showed negative before IFN treatment, but it became positive after immunoblot study no specific bands. This is the third report of following therapy.