A5004189047- Dermatology and Skin Diseases
- Genetic and rare skin diseases.
- Allergic Rhinitis and Sensitization
- Skin and Cellular Biology Research
- Dermatological and Skeletal Disorders
- Food Allergy and Anaphylaxis Research
- Hypertrophic osteoarthropathy and related conditions
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Nitric Oxide and Endothelin Effects
- Dermatologic Treatments and Research
- CRISPR and Genetic Engineering
- Asthma and respiratory diseases
- Nail Diseases and Treatments
- Chromosomal and Genetic Variations
- Acne and Rosacea Treatments and Effects
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- melanin and skin pigmentation
- RNA regulation and disease
- DNA Repair Mechanisms
- Congenital heart defects research
- Genomic variations and chromosomal abnormalities
- Animal Genetics and Reproduction
- Dupuytren's Contracture and Treatments
Keio University
2014-2024
Clinical Research Management
2022
Gene Therapy Laboratory
2013
Keio University Hospital
2007-2008
Tokyo Institute of Technology
1998
Showa University
1998
Patients with disseminated superficial actinic porokeratosis (DSAP) and linear (LP) exhibit monoallelic germline mutations in genes encoding mevalonate pathway enzymes, such as MVD or MVK. Here, we showed that each skin lesion of DSAP exhibited an individual second hit genetic change the wild-type allele corresponding gene specifically epidermis, indicating a postnatal triggering biallelic deficiency is required for to develop. Most lesions one two principal hits, either somatic homologous...
Host-microbe interactions orchestrate skin homeostasis, the dysregulation of which has been implicated in chronic inflammatory conditions such as atopic dermatitis and psoriasis. Here, we show that Staphylococcus cohnii is a commensal capable beneficially inhibiting inflammation. We find Tmem79−/− mice spontaneously develop interleukin-17 (IL-17)-producing T-cell-driven Comparative microbiome analysis reveals disease activity index negatively associated with S. cohnii. Inoculation strains...
Abstract Pachydermoperiostosis is a rare hereditary disease, which presents with the cutaneous manifestations of pachydermia and cutis verticis gyrata. Histological findings in frequently include dermal edema, mucin deposition, elastic fiber degeneration, fibrosis adnexal hyperplasia. However, severity these varies between clinical reports, systematic multiple‐case clinicopathological correlative analysis has not been performed to date. In present study, we reviewed skin biopsy specimens...
We examined the effects of various endothelins on mineralization mouse clonal preosteoblastic MC3T3-E1 cells. cells expressed mRNAs for endothelin (ET)-1 and A-type receptor ET (ET A ). pharmacological study also demonstrated predominant expression receptor. Northern blotting analysis revealed that ETs decreased mRNA osteocalcin, which is a marker protein maturation osteoblastic ET-1 in deposition calcium by dose-dependent manner it had an inhibitory effect even at 10 −11 M. The rank order...
Background – Filaggrin (FLG) is a key protein for skin barrier formation and hydration of the stratum corneum. In humans, strong association between FLG gene mutations atopic dermatitis has been reported. Although similar pathogenesis clinical manifestation have argued in canine dermatitis, our understanding limited. Hypothesis/Objectives The aim this study was to determine structure raise anti‐dog antibodies, which will be useful detect dog skin. Methods determined by analysing publicly...
The Medaka is an excellent genetic system for studies of vertebrate development and disease environmental evolutionary biology studies. To facilitate the mapping markers or cloning affected genes in mutants identified by forward-genetic screens, we have established a panel whole-genome radiation hybrids (RHs) RH maps three chromosomes. useful, since to be mapped need not polymorphic one can establish order that are difficult resolve owing low recombination rates. RHs were generated fusing...