A5005794570- Hypertrophic osteoarthropathy and related conditions
- Dermatological and Skeletal Disorders
- Autoimmune Bullous Skin Diseases
- Spectroscopy and Chemometric Analyses
- Histiocytic Disorders and Treatments
- Dermatology and Skin Diseases
- Eosinophilic Disorders and Syndromes
- Vascular Malformations and Hemangiomas
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cutaneous lymphoproliferative disorders research
- Hair Growth and Disorders
- Contact Dermatitis and Allergies
- Genetic and rare skin diseases.
- Advanced X-ray Imaging Techniques
- Tuberous Sclerosis Complex Research
- Optical Systems and Laser Technology
- Whipple's Disease and Interleukins
- Allergic Rhinitis and Sensitization
- Ultrasound Imaging and Elastography
- Asymmetric Hydrogenation and Catalysis
- Heterotopic Ossification and Related Conditions
- Fungal Infections and Studies
- Nanomaterials for catalytic reactions
- Cancer and Skin Lesions
- Eosinophilic Esophagitis
Kyoto University
2020-2025
Kitano Hospital
2021
Tohoku University
1996-2015
Keio University Hospital
2012
Saiseikai Central Hospital
2008-2009
Keio University
2008
Osaka Prefectural Government
2001
Toshiba (Japan)
1993
Children's National
1990
University North
1987
Abstract Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia. PDP with these three features, along cutis verticis gyrata (CVG), categorized as the “complete form,” whereas cases without CVG are “incomplete form.” The condition linked to elevated levels of systemic prostaglandin E2 (PGE2). About half patients experience arthralgia. standard treatment for selective cyclooxygenase (COX)‐2 inhibitors, but long‐term usage can cause...
Indeterminate cell histiocytosis (ICH) is a rare disorder, characterized by infiltration of the skin neoplastic cells that are characteristically positive for S-100 and CD1a, but lack Birbeck's granules. A 75-year-old man presented with 4-year history multiple papules on trunk, limbs, face neck. Skin biopsy revealed dense histiocytic were CD1a+/S100+, lacked No other abnormality was seen during general examination including computed tomography scan body, gallium scintigraphy, an abdominal...
Eosinophilia is recognized as a poor prognostic factor in patients with cutaneous T-cell lymphoma (CTCL). We report case of folliculotropic mycosis fungoides (FMF) presenting multiple ulcerative nodular lesions and persistent eosinophilia. Severe facial resulted leonine appearance. On histopathological examination, infiltration large CD30+ cells was seen. When the previous biopsy specimens were reviewed, marked folliculotropism atypical lymphocytes identified 20 years before blastic...
The ultrastructural characteristics and immunolocalization of in vivo bound immunoglobulin G (IgG) skin affected by anti-p200 pemphigoid have not been elucidated. To give insight into the mechanism blister formation we report a new case pemphigoid, studied with stage-oriented morphological analysis immunoelectron microscopy. Skin biopsy specimens were evaluated ultrastructurally histologically immunohistochemistry. By observing nonblister site, edge centre blister, determined that neutrophil...
A two-dimensional infrared (2D IR) spectrometer has been modified by the following methods to solve several problems on 2D IR spectroscopy of electric-field-induced reorientation dynamics a mixed nematic liquid crystal: (1) The response crystal (LC) an electric field was stabilized amplitude-modulated ac field. (2) Formulation anti-reflection coating (ARC) proposed suppress interference caused multiple reflections between cell windows. (3) Fourier transform procedure correct phase dynamic...
Fig. 1. (A) A black, erosive, dome-shaped nodule 20 mm in diameter on the right forearm.(B) pruritic erythematous swelling around injection site for interferon-β forearm.
Abstract Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia caused mutated HPGD or SLCO2A1 . Plasma prostaglandin (PG)E 2 levels are increased in these patients. However, other eicosanoids have not been quantitated. We aimed to quantitate plasma eicosanoid four patients carrying mutations high‐performance liquid chromatography–tandem mass spectrometry. PGE level was elevated all patients; PGD 11β‐PGF α were also some patients,...
Nonlinear wave propagation in a system consisting of liquid specimen held between two SiO2 buffer rods is studied as new method determining the acoustic nonlinearity parameter liquids at very high frequencies. Since sign opposite that for liquids, can be viewed transmission line containing regions both positive and negative nonlinearity. The nonlinear characterization curve employed which second harmonic component output receiving transducer plotted function distance rods. determined by...
Immune-related adverse events (irAEs) are commonly observed in patients treated with immune checkpoint inhibitors (ICI), and prompt diagnosis treatment of irAEs is utmost importance. Gastrointestinal (GI) among the most frequent hallmark symptom diarrhea. Intestinal hypomotility as exceedingly rare, needs wider recognition given that presentation insidious.Here, we report a case 79-year-old woman metastatic melanoma under nivolumab ipilimumab combination therapy. She developed ileus symptom,...
Dupilumab is a monoclonal antibody against the alpha subunit of interleukin (IL)-4 receptor that inhibits IL-4 and IL-13 signaling, which plays central role in Th2 inflammation AD.Here, we report first Asian case psoriasis unexpectedly induced by dupilumab therapy for AD. Compared with European American AD phenotype, phenotype characterized changes psoriasiform associating higher Th17 activation. The blockade IL-4/IL-13 signaling may induce eruption corresponding to shift from Th2- Th17-...
A bioultrasonic spectroscopy system and method for studies of ultrasonic tissue characterization in the VHF UHF ranges were recently developed. Bulk linear acoustic properties velocity, attenuation coefficient, impedance, density can be determined an transmission line which specimen is sandwiched between two SiO2-buffer rods, having ZnO-film transducers on their outer ends, with distilled water employed as reference medium. An extensive study nonlinear propagation behavior liquids/tissues at...