A5078020893- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Drug-Induced Adverse Reactions
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Platelet Disorders and Treatments
- Fungal Infections and Studies
- Cutaneous Melanoma Detection and Management
- Dermatology and Skin Diseases
- Infectious Diseases and Mycology
- Antifungal resistance and susceptibility
- Immunodeficiency and Autoimmune Disorders
- IgG4-Related and Inflammatory Diseases
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Contact Dermatitis and Allergies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders
- Cancer and Skin Lesions
- Mast cells and histamine
- Histiocytic Disorders and Treatments
Keio University
2016-2025
Tokushima Municipal Hospital
2024
Guangdong Academy of Medical Sciences
2023
Southern Medical University
2023
Guangdong Provincial People's Hospital
2023
Fujita Health University Hospital
2021
University of Fukui
2017-2018
Keio University Hospital
2001-2016
St Thomas' Hospital
2013
Gunma University
2011
Objective To assess the efficacy and tolerability of hydroxychloroquine (HCQ) in patients with cutaneous lupus erythematosus (CLE), a phase III clinical trial conducted Japan. Methods We double‐blind, randomized, parallel‐group trial. This was baseline‐controlled study, group differences were evaluated an exploratory analysis. A total 103 active CLE (according to Cutaneous Lupus Erythematosus Disease Area Severity Index [CLASI] activity score ≥4) included. Patients randomized 3:1 receive HCQ...
Summary Background Pemphigus is an antidesmoglein (Dsg) autoimmune disease that divided into two major subtypes: pemphigus foliaceus (PF) and vulgaris (PV). We previously developed enzyme‐linked immunosorbent assays (ELISAs) using recombinant Dsg1 Dsg3 to detect IgG autoantibodies in patients with pemphigus. The protocol for the ELISAs was optimized serological diagnosis, but under conditions used, these were not particularly useful monitoring activity certain patients. That is, sera from...
Abstract The pemphigoid group is a category of autoimmune subepidermal blistering diseases in which autoantibodies deposit linearly at the epidermal basement membrane zone ( BMZ ). main subtypes mediated by immunoglobulin G are bullous BP ), mucous MMP ) and epidermolysis bullosa acquisita EBA To establish first guidelines approved Japanese Dermatological Association for management diseases, Committee Guidelines Management Pemphigoid Diseases (Including was founded as part Study Group Rare...
The aims of this study were to provide a quantitative assessment the tumour area extracted by dermatologists and evaluate computer-based methods from dermoscopy images for refining melanoma diagnostic system. Dermoscopic 188 Clark naevi, 56 Reed naevi 75 melanomas examined. Five manually drew border each lesion with tablet computer. inter-observer variability was evaluated standard (STA) image defined. Manual extractions 10 non-medical individuals two STA-based criteria: precision recall....
Reliable and validated measures of skin disease severity are needed for cutaneous dermatomyositis (DM). Cutaneous Dermatomyositis Disease Area Severity Index (CDASI), Skin (DSSI) Assessment Tool (CAT) indices have been developed as outcome instruments.We sought to demonstrate reliability validity the CDASI, compare CDASI with other potential tools use in measuring dermatomyositis.CDASI has four activity two damage measures, scores from 0 148. DSSI assesses based on body surface area a scale...
Pemphigus is a group of autoimmune blistering diseases that affect the skin and mucous membranes. A reliable accurate disease severity tool to assess pemphigus crucial for managing clinical trials. The purpose this study was compare area index activity score (PDAI), Japanese (JPDSS) physician's subjective impression, also find appropriate grading cut-offs PDAI. We evaluated correlation between PDAI JPDSS. Thirty-seven patients 110 assessments were analyzed in study. optimal points were: mild...
Background Hydroxychloroquine (HCQ) is not available in Japan. To design a clinical trial of HCQ, we evaluated the response to HCQ Japanese patients with lupus-related skin disease using cutaneous lupus erythematosus area and severity index (CLASI). Methods Twenty-seven who started at four hospitals were included. Patients categorized into responders by CLASI criteria. The points rate improvement activity score after 16 weeks treatment analyzed, focusing on six parameters: systemic (SLE),...
Hydroxychloroquine (HCQ) is not available in Japan. To design a clinical trial of HCQ, we evaluated the response to HCQ Japanese patients with lupus-related skin disease using cutaneous lupus erythematosus area and severity index (CLASI).Twenty-seven who started at four hospitals were included. Patients categorized into responders by CLASI criteria. The points rate improvement activity score after 16 weeks treatment analyzed, focusing on six parameters: systemic (SLE), manifestations,...
In this study, we aimed to evaluate the feasibility and efficacy of peptide-pulsed dendritic cell (DC) vaccine in combination with carboplatin paclitaxel chemotherapy (DCCP) for patients stage IV melanoma previously treated dacarbazine-containing regimen. Six HLA-A24 + 3 HLA-A02 were (area under curve 5) (175 mg/m 2 ) on day 1 DCs (2×10 7 cells) pulsed Wilms tumor gene (WT1), gp100, tyrosinase, either MAGE-A3 (for or MAGE-A2 peptides days 8 22 28-day cycle up three cycles. DCCP was well...
We describe a 27-year-old Japanese female with recurrent nodule on the left big toe and local bone invasion. Histopathologically, tumor consisted of nests atypical cells few mitotic cells, which partly formed gland-like structures. Areas myxoid degeneration, positive for Alcian blue staining that did not stain after they were digested hyaluronidase, prominent in matrix among cells. Positive was noted cytokeratin (AE1+AE3), S-100 protein, neuron specific enolase (NSE), glial fibrillary acidic...
Indeterminate cell histiocytosis (ICH) is a rare disorder, characterized by infiltration of the skin neoplastic cells that are characteristically positive for S-100 and CD1a, but lack Birbeck's granules. A 75-year-old man presented with 4-year history multiple papules on trunk, limbs, face neck. Skin biopsy revealed dense histiocytic were CD1a+/S100+, lacked No other abnormality was seen during general examination including computed tomography scan body, gallium scintigraphy, an abdominal...
This was a multicenter study of rituximab, chimeric monoclonal immunoglobulin G antibody directed against CD20, for the treatment refractory autoimmune bullous diseases (pemphigus and pemphigoid). Ten patients (three with pemphigus vulgaris, six foliaceus one pemphigoid) were treated single cycle rituximab (four weekly infusions at dose 375 mg/m2 body surface area). The primary end-points number serious adverse events rate complete remission 40 weeks. Five (50%) achieved minimal therapy...
Abstract Background The Japanese guidelines for the management of pemphigus ( JG ) were published in 2010. However, further progress treatment requires their validation. Objectives To examine efficacy and safety treatments based on . Methods A retrospective study 84 patients with moderate to severe pemphigus, who initially treated accordance then followed up >2 years, was performed a single centre. Treatment typically consisted 0.5–1 mg prednisone PSL )/kg/day accompanied by 100...