A5088716178- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Cutaneous Melanoma Detection and Management
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Treatments and Studies
- Vascular Tumors and Angiosarcomas
- Gastrointestinal Tumor Research and Treatment
- melanin and skin pigmentation
- Sarcoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Vascular Malformations and Hemangiomas
- Genomics and Chromatin Dynamics
- Immunotherapy and Immune Responses
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Urological Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Histiocytic Disorders and Treatments
- Nonmelanoma Skin Cancer Studies
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Ear and Head Tumors
Kobe University
2012-2024
Kobe University Hospital
2023
Abstract Vitiligo is an acquired skin depigmentation disorder resulting from the selective loss of epidermal melanocytes, and previous studies have suggested that a T lymphocyte‐mediated mechanism has role in melanocyte loss. Although Fas‐Fas ligand (FasL) interactions are important for lymphocytes to mediate cytotoxicity, there only few reports examining involvement Fas‐FasL pathway vitiligo using vivo mouse models. In addition, been no concerning Fas‐mediated apoptosis human melanocytes...
Solar urticaria (SU) is a photodermatosis that thought to be caused through the effects of mast cell mediators released because an altered chromophore, possibly photoallergen recognized by IgE. Phototherapy for SU induce tolerant state appears most effective, but often time consuming and provides only short-lived remission. Ultraviolet (UV) A rush hardening has been successful less in serum factor-negative patients with SU. However, mechanism action long-lasting UVA therapy remain unclear.We...
Angiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, taxane (genotoxic drug), although it has limited effect owing to chemoresistance prolonged treatment. In study, we examine alternative angiosarcoma treatment approach that combines chemotherapeutic and senolytic agents. We find the drugs cisplatin paclitaxel efficiently induce senescence in cells. Subsequent agent ABT-263 eliminates senescent cells by activating...
DNA methylation is considered the primary epigenetic mechanism underlying development of malignant melanoma. Since can be influenced by environmental factors, it preferable to compare cancer and normal cells from same patient. In order status in melanoma tissues melanocytes individuals, we employed a novel epidermal sheet cultivation technique isolate unaffected sites patients. We also analyzed metastatic samples, three commercially available melanocytes, four cell lines. Cluster analysis...
The upregulation of the adaptor protein NUMB triggers melanocytic differentiation from multipotent skin stem cells, which share many properties with aggressive melanoma cells. Although acts as a tumor suppressor in various human cancer types, little is known about its role melanoma. In this study, we investigated progression and regulatory mechanism. Analysis Cancer Genome Atlas datasets revealed that high expression tissues correlates improved patient survival. Moreover, downregulated...
Regorafenib is an oral multikinase inhibitor targeting several tyrosine kinase receptors including BRAF and epidermal growth factor receptor (EGFR) approved as a third-line treatment for metastatic gastrointestinal stromal tumor (GIST). While acneiform eruptions have been observed in patients receiving other EGFR inhibitors, the commonly reported adverse reactions to regorafenib are fatigue palmar-plantar erythrodysesthesia. Herein, we report, best of our knowledge, first case who presented...
Abstract Angiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, one of the taxanes (genotoxic drugs), although it has limited effect due to chemoresistance prolonged treatment. Here we examine new angiosarcoma treatment approach that combines chemotherapeutic and senolytic agents. We first find drugs, cisplatin efficiently induce cellular senescence cells. Subsequent agent, ABT-263, eliminates senescent cells...
Intravenous immunoglobulins (IVIg) are increasingly being used to treat a wide spectrum of dermatological and neurological autoimmune diseases. Although the administration IVIg does not usually result in severe adverse reactions, side effects reportedly occur 6-13% patients. Most reported cases were severe, is considered relatively safe drug. Some reports described vesicular eczematous eruption caused by that was cured applying topical steroid ointments or systemic steroids. Herein, we...
Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that classically occurs in the genitals as well-circumscribed, ivory or white, shiny, scar-like plaques middle-aged and elderly women [1, 2]. LS can also appear extragenital regions with variety of clinical presentations. Telangiectatic one such morphological variant [3], but number reported cases this very low. To best our knowledge, only three telangiectatic [...]
Introduction: The healing of recurrent and refractory skin ulcers requires a long time, during which there is risk infection, hospital admission occasionally required for surgical or daily conservative treatment. Therefore, the development promising treatments that promote faster, uneventful must. Composed cryoprecipitate thrombin, fibrin glue has history use preventing bleeding spinal fluid leakage. Moreover, in-house cryoprecipitates contain higher concentrations coagulation factors...
50歳，女性。3年前より右後頭部に自発痛・脱毛斑を伴う小結節が出現し，増大した。病理組織学的にアポクリンへの分化を有する腺癌を認め，免疫染色ではCK7陽性かつCK20陰性，ER，PR，ARはすべて陽性，GCDFP－15陽性，p63陰性，D2－40陰性を示した。PETを含む全身検索では乳癌を含む他臓器癌を認めず，皮膚に原発したアポクリン腺癌と診断した。後頭部病変を拡大切除し1年経過したが，再発や転移は認めていない。皮膚原発アポクリン腺癌は乳癌の皮膚転移と病理組織学上鑑別困難であるため，最終的に臨床経過で診断するに至った。
Regorafenib is an oral multikinase inhibitor targeting several tyrosine kinase receptors including BRAF and epidermal growth factor receptor (EGFR), approved as a third-line treatment for metastatic gastrointestinal stromal tumor (GIST). While acneiform eruptions have been observed in patients receiving other EGFR inhibitors, the commonly reported adverse reactions to regorafenib are fatigue palmar-plantar erythrodysesthesia. Herein, we report, best of our knowledge, first case who presented...