A5028021513- Genetic diversity and population structure
- CRISPR and Genetic Engineering
- Fish Biology and Ecology Studies
- Genetics, Aging, and Longevity in Model Organisms
- Animal Behavior and Reproduction
- BRCA gene mutations in cancer
- Primate Behavior and Ecology
- Fish Ecology and Management Studies
- Mechanisms of cancer metastasis
- Reproductive Biology and Fertility
- Evolutionary Game Theory and Cooperation
- Gene expression and cancer classification
- Reproductive biology and impacts on aquatic species
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Aquatic Ecosystems and Biodiversity
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Genetics, Bioinformatics, and Biomedical Research
Clovis Community College
2022
Stanford University
2006-2016
Johns Hopkins University
2005-2008
Carnegie Institution for Science
2006-2008
Department of Embryology
2006
Carnegie Observatories
2006
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand molecular mechanisms underlying cichlid phenotypic diversity, we sequenced genomes transcriptomes five lineages African cichlids: Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; four members lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent Malawi), Pundamilia nyererei (very recent...
Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, response results a hypomorphic phenotype where recede F1 generation. F2 and subsequent revert to original phenotype. Specific examples transgenerational which generation beyond have been described. this study, we describe systematic pedigree-based analysis heritable processes resulting from initiation...
We describe a surprising long-range periodicity that underlies substantial fraction of C. elegans genomic sequence. Extended segments (up to several hundred nucleotides) the genome show strong bias toward occurrence AA/TT dinucleotides along one face helix while little or no such constraint is evident on opposite helical face. Segments with this characteristic are highly overrepresented in intron sequences and associated large genes known germline expression elegans. In addition altering...
Summary Life experiences can alter cognitive abilities and influence social rank. Here we asked whether differences in experience could affect status. In hierarchical animal societies, high ranking males that typically win aggressive encounters gain territories hence access to mates. To understand the relative contributions of physical environment on status, used a highly territorial African cichlid fish species, Astatotilapia burtoni, lives dynamic lek-like hierarchy. A. burtoni are either...
ABSTRACT Male African cichlid fish, Astatotilapia burtoni, have been classified as dominant or subordinate, each with unique behavioral and endocrine profiles. Here we characterize two distinct subclasses of males based on types aggressive behavior: (1) that display escalating levels aggression court females while they establish a territory, (2) stable level delay courting until established territory. To profile differences in their approach to challenge, used an intruder assay. In every...
The prune gene of Drosophila melanogaster is predicted to encode a phosphodiesterase. Null alleles are viable but cause an eye-color phenotype. abnormal wing discs encodes nucleoside diphosphate kinase. Killer missense mutation in the gene. Although it has no phenotype by itself even when homozygous, heterozygous causes lethality absence function. A screen for suppressors transgenic led recovery three mutations, all which same As heterozygotes these mutations dominant prune-Killer lethal...
Over the last 20 years, there has been an explosion of genomic data collected for disease association, functional analyses, and other large-scale discoveries. At same time, have revolutions in cloud computing that enable computational science research, while making accessible to anyone with a web browser internet connection. However, students at institutions limited resources received relatively little exposure curricula or professional development opportunities lead careers science. To...