A5101486598- Cancer-related molecular mechanisms research
- Myofascial pain diagnosis and treatment
- Legume Nitrogen Fixing Symbiosis
- Bone and Dental Protein Studies
- Microbial infections and disease research
- Acupuncture Treatment Research Studies
- Bone Metabolism and Diseases
- Bacillus and Francisella bacterial research
- Ferroptosis and cancer prognosis
- Carbon and Quantum Dots Applications
- MicroRNA in disease regulation
- Rabies epidemiology and control
- Plant pathogens and resistance mechanisms
- Soybean genetics and cultivation
- Gene expression and cancer classification
- Oral and gingival health research
- Pain Management and Placebo Effect
- Calpain Protease Function and Regulation
- Oral and Maxillofacial Pathology
- Cancer Mechanisms and Therapy
- Wound Healing and Treatments
- Nematode management and characterization studies
- GDF15 and Related Biomarkers
- Urinary Tract Infections Management
- Bone health and treatments
BGI Genomics
2024-2025
BGI Group (China)
2024-2025
Xuzhou Medical College
2022-2024
Second Affiliated Hospital of Harbin Medical University
2020-2024
Harbin Medical University
2020-2024
McGill University
2022
University of British Columbia
2022
China Agricultural University
2021
Northeast Agricultural University
2013-2018
Tianjin Normal University
2007
Article18 December 2007Open Access A map of human cancer signaling Qinghua Cui Computational Chemistry and Biology Group, Biotechnology Research Institute, National Council Canada, Montreal, QC, Canada Search for more papers by this author Yun Ma Department Biology, Tianjin Normal University, Tianjin, China Maria Jaramillo Receptor, Signaling Proteomics Hamza Bari Arif Awan Song Yang School Chemical Engineering, Simo Zhang Lixue Liu Meng Lu Maureen O'Connor-McCourt Enrico O Purisima Center...
Hydrogels are widely used as wound dressings for healing, but when hydrogels absorb exudate, swelling occurs and compresses the surrounding tissue, affecting healing. A chitosan injectable (CS/4-PA/CAT) hydrogel based on catechol 4-glutenoic acid was prepared to avoid promote After cross-linking by UV light, pentenyl groups formed hydrophobic alkyl chains which give a network thus control its swelling. CS/4-PA/CAT retained their non-swelling long time in PBS solution at 37 °C. had good...
Summary The present study screened for polymorphisms in coding and non‐coding regions of the Gm GBP 1 gene 278 soybean accessions with variable maturity growth habit characteristics under natural field conditions three different latitudes China. results showed that promoter region was highly diversified compared sequence . Five four haplotypes were closely related to flowering time through association linkage disequilibrium analyses. Varieties SNP _‐796G, _‐770G, _‐307T, InDel_‐242normal,...
Maxillofacial infection is a common disease in stomatology and difficult to treat owing its high potential spread vital anatomical structures. Excessive levels of reactive oxygen species (ROS) infected tissues lead cellular damage impede tissue regeneration. However, uncontrollable strategies remove ROS have limited therapeutic efficacy. Nanoparticle systems for scavenging remodeling the inflammatory microenvironment offer much promise treatment maxillofacial inflammation.Here, novel...
Rabies is an acute and lethal zoonotic disease caused by the rabies virus (RABV). After onset, there are no effective drugs or treatment methods. A 49-year-old female from Hefei, Anhui Province, China, presented to a local hospital with fever, pruritus, chest distress, shortness of breath. During consultation, patient exhibited agitation was later admitted intensive care unit (ICU) in for endotracheal intubation mechanical ventilation due worsened dyspnea. Cerebrospinal fluid (CSF) blood...
Background Cell survival or death is one of the key scientific issues inflammatory response. To regulate cell during occurrence and development periodontitis, various forms programmed death, such as pyroptosis, ferroptosis, necroptosis, apoptosis, have been proposed. It has found that ferroptosis characterized by iron-dependent lipid peroxidation involved in cancer, degenerative brain diseases diseases. Furthermore, NCOA4 considered ferroptosis-related genes (FRGs) contributing to...
Bisphosphonates (BPs) are some of the most widely used drugs in osteoporosis (OP) treatment, but they can cause severe side effects such as bisphosphonate-related osteonecrosis jaw (BRONJ), causing great pain patients. It is necessary to develop a novel drug for treating OP with fewer effects. In this study, carbon dots, ALEN-CDs, derived from polyethylene glycol (PEG) and alendronate (ALEN) developed. ALEN-CDs have good biocompatibility, photoluminescence (PL) properties, bone-targeting...
Abstract Background: The family with sequence similarity 20-member C (Fam20C) kinase plays important roles in physiopathological process and is responsible for majority of the secreted phosphoproteome, including substrates associated tumor cell migration. However, it remains unclear whether Fam20C a role cancers. Here, we aimed to analyze expression prognostic value pan-cancer gain insights into association between immune infiltration. Methods: We analyzed patterns associations levels...
The interkingdom coevolution innovated the rhizobium-legume symbiosis. application of this nitrogen-fixing system in sustainable agriculture is usually impeded by incompatible interactions between partners. However, progressive evolution compatibility remains elusive. In work, deletions rhcV encoding a structural component type three secretion allow related Sinorhizobium strains to nodulate previously soybean cultivar (Glycine max). These mutants show low medium high symbiotic efficiency on...
Lyophilized platelet-rich fibrin (L-PRF) was shown to further activate resident platelets in causing a higher amount of growth factors release. However, it still required experimental studies resolve the uncontrolled degradation and burst release problem. In this study, nature crosslinker genipin is introduced improve performance L-PRF scaffold. We used series gradient concentration solutions react with L-PRF. The crosslinking degree, micro morphology, mean pore size, water absorption...
Abstract Background The family with sequence similarity 20-member C (FAM20C) kinase, a Golgi casein which is responsible for phosphorylating the majority of extracellular phosphoproteins within S-x-E/pS motifs, and fundamentally associated multiple biological processes to maintain cell proliferation, biomineralization, migration, adhesion, phosphate homeostasis. In dissecting how FAM20C regulates downstream molecules potential mechanisms, however, there are target FAM20C, particularly many...
Chlamydia abortus is a pathogen capable of infecting both humans and animals. In most known cases, this primarily infects pregnant women, leading to miscarriage preterm birth. However, it exceedingly rare for cause pneumonia that progresses severe Acute Respiratory Distress Syndrome (ARDS).
Introduction Aspirin is a common antipyretic, analgesic, and anti-inflammatory drug, which has been reported to extend life in animal models application the treatment of aging-related diseases. However, it remains unclear about effects aspirin on bone marrow-derived mesenchymal stromal cells (BM-MSCs). Here, we aimed analyze influence senescence young BM-MSCs. Methods BM-MSCs were serially passaged construct replicative model. SA-β-gal staining, PCR, western blot, RNA-sequencing performed...
Stem cells from fetal tissue protect against aging and possess greater proliferative capacity than their adult counterparts. These can more readily expand in vitro senesce later culture. However, the underlying molecular mechanisms for these differences are still not fully understood. In this study, we used a robust rank aggregation (RRA) method to discover differentially expressed genes (DEGs) between bone marrow mesenchymal stem (fMSCs) aged (aMSCs). Multiple methods, including gene set...
The plant microbiome is shaped by development and microbial interaction. Fungal pathogens infecting bell pepper plants may fluctuate across the growing seasons. Dynamic fluctuation of fungal in poorly understood, origin causing fruit rot leaf wilt has been barely investigated. In this study, we used amplicon sequencing (i.e., 16S rRNA internal transcribed spacer [ITS] sequencing) to explore compositional variations studied Co-occurrence network analysis was applied track dissemination route...
Abstract Bone damage results from the imbalance of bone homeostasis maintained by osteoblast‐regulated formation and osteoclast‐mediated resorption. Conventional drug therapy gene may not optimally regulate remodeling process due to unitary pharmacological mechanism safety targeting vectors. In present study, multifunctional fluorescent alendronate‐polyethyleneimine carbon dots (Alen‐PEI CDs) are innovatively synthesized, which have excellent biocompatibility, selective targeting, carrying...
Short Root Defects defined by a reduced ratio of root to crown, may culminate in resorption and subsequent tooth loss, spite the absence apparent symptoms. Such defects present considerable impediments orthodontic treatment restoration. Recent identification Fam20a, an emergent pseudokinase, has been associated with enamel development eruption, yet its definitive role formation eruption remains ambiguous. In this research, we initially ascertained that targeted knockout Fam20a within...
Family with sequence similarity 20 member C (FAM20C) is a Golgi casein kinase that phosphorylates extracellularly-secreted regulatory proteins involved in bone development and mineralization, but its specific role still largely unknown. In this study, to examine the mechanisms FAM20C influences development, we cross-bred Osx-Cre
<title>Abstract</title> Background Rabies is an acute and lethal zoonotic disease caused by the rabies virus (RABV). After onset, there are no effective drugs or treatment methods. We reported a fatal case with clear history of animal bites atypical early clinical symptoms. And unexpectedly, we discovered that unique RABV sequences were detected in patient's saliva metagenomic next-generation sequencing (mNGS). The patient was diagnosed based on results mNGS, real-time reverse transcriptase...
To compare the difference in clinical efficacy on piriformis syndrome between trigger-point (TrP) acupuncture and glucocorticoid injection.
The aberrant expression of AEG-1 is significantly correlated with tumorigenesis, development, neurodegeneration and inflammation. However, the relationship between immune infiltration in OSCC, as well other tumor types, has yet to be comprehensively analyzed.
To compare the clinical efficacy between trigger-point (TrP) electroacupuncture and transversus abdominis plane (TAP) block in treatment of chronic abdominal wall pain (CAWP).