A5100327616- Gastric Cancer Management and Outcomes
- Hip disorders and treatments
- MicroRNA in disease regulation
- Orthopaedic implants and arthroplasty
- Metastasis and carcinoma case studies
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Renal Transplantation Outcomes and Treatments
- Shoulder Injury and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Hip and Femur Fractures
- Renal Diseases and Glomerulopathies
- Inflammatory Biomarkers in Disease Prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA modifications and cancer
- Cardiac Valve Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Liver Disease and Transplantation
Shandong Center for Disease Control and Prevention
2025
Fudan University
2021-2025
Peking University Third Hospital
2021-2025
Shanghai Changzheng Hospital
2013-2025
Sun Yat-sen University
2024-2025
Sun Yat-sen University Cancer Center
2024-2025
Gansu University of Traditional Chinese Medicine
2023-2025
China West Normal University
2025
Huashan Hospital
2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2024
Abstract Hepatocyte nuclear factor 4α (HNF4α) is a transcription that plays key role in hepatocyte differentiation and the maintenance of hepatic function, but its hepatocarcinogenesis has yet to be examined. Here, we report evidence suppressor for HNF4α liver cancer. expression was progressively decreased diethylinitrosamine-induced rat model carcinogenesis. In human tissues, cirrhotic tissue further hepatocarcinoma relative healthy tissue. Notably, an inverse correlation existed with...
OBJECTIVE LY2963016 (LY IGlar) and Lantus (IGlar) are insulin glargine products manufactured by distinct processes but with identical amino acid sequences. Three studies evaluated the pharmacokinetic (PK) pharmacodynamic (PD) similarity of LY IGlar European Union– US-approved versions IGlar. RESEARCH DESIGN AND METHODS These were three single-site, randomized, double-blind, two-treatment, four-period, crossover, euglycemic clamp studies. In each study, fasted healthy subjects received 0.5...
Hepatocyte nuclear factor-4α (HNF4α) is a dominant transcriptional regulator of hepatocyte differentiation and hepatocellular carcinogenesis. There striking suppression carcinoma (HCC) by HNF4α, although the mechanisms which HNF4α reverses HCC malignancy are largely unknown. Herein, we demonstrate that administration to cells resulted in elevated levels 28 mature microRNAs (miRNAs) from miR-379-656 cluster, located delta-like 1 homolog (DLK1) -iodothyronine deiodinase 3 (DIO3) locus on human...
To analyze the compositions of upper urinary tract stones and investigate their distributions in different gender age groups.Patients diagnosed with stone disease between December 2014 March 2018 were retrospectively reviewed. Patient's age, gender, BMI, comorbidities, event characteristics, collected, proportions components groups analyzed.A total 1532 analyses performed (992 from males 540 females). The mean was younger (p<0.001). Males included more cases larger hyperuricemia, obesity,...
Background— The selection of patients with renal artery stenosis (RAS) likely to improve glomerular filtration rate (GFR) after percutaneous transluminal angioplasty is difficult. We examined basal hemodynamic and inflammatory factors linked improved stenotic kidney (STK) function in swine RAS. Methods Results— Fifteen pigs 6 weeks hemodynamically significant RAS were studied before 4 technically successful angioplasty+stenting. STK contralateral hemodynamics evaluated by multidetector...
The forkhead box transcription factor A2 (FOXA2) is a member of the hepatocyte nuclear family and plays an important role in liver development metabolic homeostasis, but its metastasis hepatocellular carcinoma (HCC) has not been evaluated. In this study, we found that expression FOXA2 was decreased 68.1% (49/72) human HCC tissues compared with their paired non-cancerous adjacent tissues. Clinicopathological analysis revealed reduced correlated aggressive characteristics (venous invasion,...
Abstract Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, undergoes active renal tubular secretion. Baricitinib was not predicted to inhibit hepatic uptake efflux drug transporters, based on the ratio of unbound maximum eliminating‐organ inlet concentration in vitro half‐maximal inhibitory concentrations (IC 50 ). In , baricitinib a substrate for organic anion transporter (OAT)3, multidrug toxin extrusion protein (MATE)2‐K, P‐glycoprotein (P‐gp), breast cancer resistance...
Abstract Spontaneous bacterial peritonitis (SBP) is a common complication of liver cirrhosis. This study was performed to compare the microbiological characteristics nosocomial and community-acquired episodes in China. Five hundred seventy-five strains were isolated from ascitic fluid cirrhotic patients Beijing 302 Hospital January 2014 December 2014. The SBP (n = 264) 311) groups exhibited significant differences clinical symptoms (P < 0.01). In both groups, most bacteria Escherichia...
Advanced lung cancer inflammation index (ALI) has been implicated in the prognosis of many types tumors. But few studies elucidate its role gastric (GC).We consecutively recruited 615 GC patients who underwent radical gastrectomy. Patients were grouped according to ALI status. Risk factors for overall survival (OS) and disease-free (DFS) sex-stratified cohorts determined using multivariate cox regression analysis. We also compared differences between two groups after one-to-one propensity...
To evaluate the incidence and risk factors of postoperative pneumonia (POP) in geriatric patients with a hip fracture after surgery, to design predictive nomogram, validate accuracy nomogram.Retrospective study.A tertiary hospital affiliated medical university.We retrospectively studied 1285 surgical-treated from April 2010 2018.Surgical treatment was performed on this study. The procedure methods were classified as: total arthroplasty, hemiarthroplasty, percutaneous fixation, intramedullary...
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). Anxiety and depression are most common psychiatric comorbidities MS, which seriously affect patients' quality life, treatment compliance, prognosis. However, current treatments for anxiety in MS show low therapeutic efficacy significant side effects. In present study, we explored effects a novel low-toxic anti-inflammatory drug, nanoparticulate magnesium hydride (MgH2), on mood disorders MS....
Reduced graft failure rates have been reported after anterior cruciate ligament (ACL) reconstruction combined with anterolateral complex (ALC) augmentation. However, the preoperative diagnosis of concomitant ALC injury remains a clinical challenge.
Abstract The tripartite motif ( TRIM ) family comprises more than 70 members involved in the regulation of many cellular pathways. 32 acts as an E3 ubiquitin ligase and has been reported to participate human cancers. Here, we aimed investigate role gastric cancer GC clinical implications. High expression was observed tissues cell lines, significantly associated with poor prognosis. Knockdown remarkably suppressed proliferation, migration, invasion cells vitro tumour growth vivo, whereas...
The liver-enriched transcription factor Forkhead Box A2 (FOXA2) has been reported to be involved in bile acid homeostasis and duct development. However, the role of FOXA2 liver fibrogenesis remains undefined. In this study, we found that abundance was significantly lower fibrotic livers patients mice treated with CCl4 than controls. Interestingly, expression level decreased hepatocytes, whereas elevated hepatic stellate cells (HSCs) mouse livers. Hepatocyte-specific ablation adult...
Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role IPF, but the studies about serum OPN AE-IPF are unclear. We aimed to investigate whether had potential prognostic value acute IPF.Thirty-two patients with AE-IPF, 39 S-IPF, 20 healthy controls were included. Serum KL-6 levels compared between S-IPF. Logistic regression analysis was applied identify predicted for AE....
Abstract Background Anti-melanoma differentiation-associated protein-5 (anti-MDA5) positive patients are characterized by the high mortality rate caused interstitial lung disease (ILD). We conducted a retrospective study to summarize clinical features and identify initial predictors for death in anti-MDA5 patients. Methods designed cohort of The demographic data recorded on first admission, as well outcomes during six months follow-up, were collected. Predictors rapidly progressive ILD...