A5101769157- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Polysaccharides and Plant Cell Walls
- Natural Antidiabetic Agents Studies
- Nanoplatforms for cancer theranostics
- Ideological and Political Education
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Appendicitis Diagnosis and Management
- Advanced Glycation End Products research
- Herpesvirus Infections and Treatments
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Innovations in Medical Education
- Curcumin's Biomedical Applications
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
Second Military Medical University
2008-2020
Shanghai Changzheng Hospital
2008
In this study, we aimed to investigate the effects of curcumin on cell activities gastric cancer (GC), and connection between P53, as well as, PI3K signaling. This study was conducted with two lines SGC-7901 BGC-823, both were exposed at concentrations 0, 10, 20, 40 μm. MTT assay, flow cytometry (FCM) transmission electron microscopy (TEM) used underlying mechanisms in respective proliferation, apoptosis, autophagy. Western blot assay also employed detect impacts tophosphatidylinositol-3...
Abstract The tripartite motif ( TRIM ) family comprises more than 70 members involved in the regulation of many cellular pathways. 32 acts as an E3 ubiquitin ligase and has been reported to participate human cancers. Here, we aimed investigate role gastric cancer GC clinical implications. High expression was observed tissues cell lines, significantly associated with poor prognosis. Knockdown remarkably suppressed proliferation, migration, invasion cells vitro tumour growth vivo, whereas...
Background: Previous studies have described the effects of Escin on improving survival rate endotoxemic animals. The purpose this study was to explore molecular mechanisms potentially beneficial treatment. Methods: First, mice monitored for up 2 weeks after pretreatment, post-treatment, or post-treatment + rHMGB1. release pro-inflammatory cytokines such as TNF-a, IL-1ß, IL-6 and HMGB1 in serum LPS-induced macrophages were evaluated by ELISA. Furthermore, mRNA protein levels measured qRT-PCR...
The prognosis for patients with gastric cancer (GC) is usually poor, as the majority of have reached advanced stages disease at point diagnosis. Therefore, revealing mechanisms GC necessary identification key biomarkers and development effective targeted therapies. present study aimed to identify long non-coding RNAs (lncRNAs) prominently expressed in GC. dataset (including 384 samples) was downloaded from Cancer Genome Atlas database training set. A number other datasets were obtained Gene...
Aberrant expression of choline kinase alpha (CHKA) has been reported in a variety human malignancies including colorectal carcinoma (CRC). However, the role CHKA progression and prognosis CRC remains unknown. In this study, we found that was frequently upregulated clinical samples CRC-derived cell lines significantly correlated with lymph node metastasis (p = 0.028), TNM stage 0.009), disease recurrence 0.004) death < 0.001). Survival analyses indicated patients higher had shorter...
Objective To investigate the influence of in vitro artificial CO2 cavity on matrix metalloproteinase 2(MMP-2), adhesion molecule vascular cell 1(VCAM-1), and intercellular 1(ICAM-1)expression MDA-MB-231 cell. Methods An model was established. cells were exposed to under pressure 7 mmHg for 1, 2 4 hours, respectively. MMP-2 concentration measured by enzyme linked immunosorbent assay(ELISA). VCAM-1 ICAM-1 expression flow cytometry 0, 24, 48 72 hours after CO2-insufflation. Hypoxia group...
The aim of this paper is to discuss the method that may cultivate medical stuedents,scientific diathesis during clinical teaching. We organized 48 students experience 6 steps scientific ability cultivation 2 years. have grasped fundamental methods and also some initial trials. They accomplished about 20 thesis. systemic can promote students' consciously study, expand new knowledge, improve professional skills. Key words: Scientific research edncation; Clinical teaching; Method
Objective To explore the value of practicing PBL which was guided by MDT in teach-ing diagnoses and treatments war wound trauma caused compound agents. Methods An emula-tional case factors designed a multi-disciplinary team been orga-nized, then totally 45 interns who would graduate 2017 were divide into two groups randomly, experimental group had 23 cases received model combined with followed six step procedure in-cluded preparation teachers, independent analysis discussion interns,...