A5023487179- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and preeclampsia studies
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Medical Research and Treatments
- Preterm Birth and Chorioamnionitis
- Metabolomics and Mass Spectrometry Studies
- Gynecological conditions and treatments
- Pregnancy-related medical research
- Pregnancy and Medication Impact
- Endometrial and Cervical Cancer Treatments
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Global Cancer Incidence and Screening
- Congenital Diaphragmatic Hernia Studies
- Urological Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- Ovarian function and disorders
- Genital Health and Disease
- Uterine Myomas and Treatments
- Gestational Trophoblastic Disease Studies
- Health Sciences Research and Education
Renji Hospital
2009-2024
Shanghai Jiao Tong University
2007-2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
National Institute of Hospital Administration
2024
Peking University Third Hospital
2023
Peking University
2020-2023
Beijing University of Chinese Medicine
1999-2023
Sun Yat-sen University
2010-2022
Peking University First Hospital
2022
Abstract Preeclampsia (PE) is regarded as a pregnancy-associated hypertension disorder that related to excessive inflammatory responses. Although the gut microbiota (GM) and short-chain fatty acids (SCFAs) have been hypertension, their effects on PE remain unknown. We determined GM abundance faecal SCFA levels by 16S ribosomal RNA (rRNA) sequencing gas chromatography, respectively, using samples from 27 patients with severe 36 healthy, pregnant control subjects. found had significantly...
Abstract Pre‐eclampsia ( PE ) is a life‐threatening multisystem disorder leading to maternal and neonatal mortality morbidity. Emerging evidence showed that activation of the complement system implicated in pathological processes . However, little known about detailed cellular molecular mechanism development In this study, we reported 5a (C5a) plays pivotal role aberrant placentation, which essential for onset We detected an elevated C5a deposition macrophages receptor (C5aR) expression...
Background: Previous studies have described the effects of Escin on improving survival rate endotoxemic animals. The purpose this study was to explore molecular mechanisms potentially beneficial treatment. Methods: First, mice monitored for up 2 weeks after pretreatment, post-treatment, or post-treatment + rHMGB1. release pro-inflammatory cytokines such as TNF-a, IL-1ß, IL-6 and HMGB1 in serum LPS-induced macrophages were evaluated by ELISA. Furthermore, mRNA protein levels measured qRT-PCR...
Abstract Background Progesterone plays an important role in the proliferation and differentiation of human endometrial cells (hECs). Large-dose treatment with progesterone has been used for proliferative disorders. However, mechanisms behind remain unknown. Methods To investigate cyclin B1 hECs menstrual cycle, expression throughout cycle was evaluated hECs. determine effects on proliferation, cell progression apoptosis to test if is involved these effects, and/or Alsterpaullone (Alp, a...
One of the widely accepted conjectures regarding mechanisms aging is probably oxidative stress hypothesis. β-1,3-Glucans, well-known immunostimulants, have been shown to increase nonspecific immunity and resistance against infections or pathogenic bacteria in several fish species, but its antiaging function remains poorly understood. By feeding β-1,3-glucans annual fish, Nothobranchius guentheri, we detected survivorship estimated development age-related biomarkers at different stages. We...
ABSTRACT Endometrial receptivity is crucial for successful embryo implantation. It regulated by multiple factors which include ovarian steroid hormones and the immune microenvironment among others. Nod-Like Receptor Pyrins-3 (NLRP3) a key intracellular pattern-recognition receptor critical component of inflammasome, plays an essential role in development inflammation responses. However, physiological functions NLRP3 endometrium remain largely unclear. This study investigated pathological...
Abstract This study assessed the efficacy of ThinPrep cytologic test and human papillomavirus (HPV) co-test in cervical cancer screening during pregnancy. A cohort 8,712 pregnant women from Ren Ji Hospital participated study. Among them, 601 (6.90%) tested positive for high-risk HPV (HR-HPV) 38 (0.44%) exhibited abnormal cytology results (ASCUS+). Following HR-HPV findings, 423 patients underwent colposcopy, 114 individuals suspected having high-grade squamous intraepithelial lesion (HSIL+)...
Graft-versus-host disease (GVHD) remains a main complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Human leukocyte antigen G (HLA-G) is non-classical class I molecule exerting multiple immunoregulatory functions. The aim this study was to explore the relationship between soluble HLA-G (sHLA-G) and GVHD after allo-HSCT.The sHLA-G levels were examined using enzyme-linked immunosorbent assay in patients with hematological malignancies (n = 106) before...
The aim of this study was to assess knowledge, attitudes and practices amongst public health undergraduates in relation antimicrobial resistance (AMR) China.A cross-sectional survey conducted all final-year from 18 universities across China. A structured questionnaire used collect information on AMR-related practices, whilst multivariable linear logistic regressions were employed detect associations among these three aspects.A total 1115 participants included study. mean ± standard deviation...
The role of vitamin D (VD) in IVF outcome and immune parameters has not been elucidated well.Women undergoing treatment with GnRH agonist (Agonist) progestin-primed ovarian stimulation (PPOS) protocols were divided into VD lower (VDL, 25(OH)VD ≤20 ng/mL) higher (VDH, >20 groups. Follicular fluid (FF) level, outcomes, peripheral blood immunophenotypes by flow cytometry analyzed.FF levels the whole subjects positively correlated level (r = 0.86, P < 0.001). number mature oocytes blastocyst...
We aimed to evaluate the utility of p16/Ki-67 dual-stained cytology for triaging human papillomavirus (HPV)-positive women.HPV-positive women ages ≥ 21 years were recruited in a multicenter prospective observational study between May 2016 and 2017. The clinical performance cytology, with or without HPV16/18 genotyping, was evaluated all HPV-positive detect cervical intraepithelial neoplasia grade 2 worse (CIN2+).846 valid biopsies enrolled this study. For CIN2+ detection, showed...
BMP2 is a critical factor that involved in the processes of embryo implantation and uterine decidualization. The expression cyclooxygenase (COX) subsequent prostaglandin E2 (PGE2) production are for successful pregnancy. However, it not clear whether can regulate PG during endometrial aim this study was to investigate effects on COX-1 PGE2 as well underlying molecular mechanisms human endometrium. Immortalized stromal cells (HESCs) decidual (HDSCs) were used model BMP2-induced cellular...
To study the effect of essential oils Citrus sinensis L., Mentha piperita Syzygium aromaticum and Rosmarinus officinalis L. on physical exhaustion in rats.Forty-eight male Wistar rats were randomly divided into a control group, fatigue an oil mixture (EOM) peppermint (PEO) group. Loaded swimming to was used as rat model. Two groups nebulized with EOM PEO after swimming, others distilled water. After continuous inhalation for 3 days, time, blood glucose, lactic acid (BLA), urea nitrogen...
The purpose of this experiment is to establish a rat model thin endometrium and explore the effect ligustrazine on rats. was made by using infusing absolute ethyl alcohol into uterine cavity. thickness measured. Hematoxylin-Eosin (HE) staining used observe histopathological changes endometrium. mRNA levels VEGF, VEGFR-2, PI3K, AKT were detected RT-PCR. Western blotting detect in endometrial tissue. group significantly thinner than that control group. Compared with group, increased. HE shown...