A5006415180- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Cardiac pacing and defibrillation studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- ECG Monitoring and Analysis
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cardiac Valve Diseases and Treatments
- Structural Integrity and Reliability Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Bioinformatics and Genomic Networks
- Cardiovascular Function and Risk Factors
- Psoriasis: Treatment and Pathogenesis
- Receptor Mechanisms and Signaling
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Alcohol Consumption and Health Effects
- Cancer, Lipids, and Metabolism
Shanghai Institute of Optics and Fine Mechanics
2025
Shanghai Xuhui Central Hospital
2018-2024
Fudan University
2021-2023
Affiliated Zhongshan Hospital of Dalian University
2019-2023
Henan University of Technology
2023
Western University
2019-2021
Zhongda Hospital Southeast University
2014-2018
National University of Defense Technology
2017
First Affiliated Hospital of Dalian Medical University
2006-2016
Dalian Medical University
2006-2016
The impact of crystal birefringence on the performance diamond Raman lasers has been studied previously at power levels slightly above threshold. However, operating far threshold usually exhibit different properties. Using Metripol polarimetry, we obtained intensity and fast-axis distribution a home-made single-crystal diamond. effects Stokes laser were then investigated in an external nanosecond-laser pumped cavity with low Q-factor. When pump exceeds 1.5 times threshold, output is...
Introduction: Pulmonary vein (PV) isolation has proven to be an effective therapy for atrial fibrillation (AF). However, clinical evidence suggests that suppression of AF after PV could not fully attributed the interruption electrical conduction in and out PVs. Furthermore, little is known regarding effects ablation around PVs on electrophysiological properties. We aimed study changes response vagal stimulation (VS) (PVA). Methods: studied 11 adult mongrel dogs under general anesthesia....
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Up to date, HCC pathogenesis has not been fully understood. The aim the present study was identify crucial genes and pathways associated with by bioinformatics methods. differentially expressed (DEGs) between 14 tissues corresponding non-cancerous were identified using limma package. Gene Ontology (GO) KEGG pathway enrichment analysis DEGs performed clusterProfiler protein-protein interaction (PPI) network...
Objective Damage to intestinal epithelial tight junctions plays an important role in sepsis. Recently we found that Carbon Monoxide-Releasing Molecule-2 (CORM-2) is able protect LPS-induced junction damage and this study will investigate if CORM-2 could the rat cecal ligation puncture (CLP) model. Materials Methods The CLP model was generated using male Sprague-Dawley (SD) rats according standard procedure treated with or inactive (iCORM-2), 8 mg/kg, i.v. immediately after induction...
Background: Left bundle branch area pacing (LBBAP) is a recently proposed method for conduction system pacing. We performed meta-analysis of controlled studies to compare the clinical outcome in patients who received LBBAP vs. biventricular (BVP) cardiac resynchronization therapy (CRT). Methods: PubMed, Embase, and Cochrane's Library databases were searched relevant studies. A random-effect model incorporating potential heterogeneity was used synthesize results. Results: Four non-randomized...
Right atrial reentrant tachycardia resulting from lower loop reentry (LLR) around the inferior vena cava (IVC) has been described recently. However, all reported cases of LLR in literature have negative flutter waves on surface ECG leads similar to that counterclockwise typical tricuspid annulus (TA). with positive assumed rotate as a single activation wave front TA, and role those patients is not known.Twelve consecutive morphology consistent clockwise were studied. The endocardial pattern...
Background Left ventricular remodeling ( LV r) is common after ST ‐segment elevation myocardial infarction STEMI ). The aim of this study was to evaluate the prognostic value speckle tracking echocardiography STE ) for predicting r 6–9 months late percutaneous coronary intervention PCI in patients with . Methods Patients first who accepted were enrolled. Echocardiography performed within 48 hours admission. Six nine MI , an examination repeated. defined as >15% increase end‐systolic...
Abstract MiR-124 functions as a tumor suppressor and plays an important role in tumorigenesis. A common polymorphism (rs531564, C>G) the pri-miR-124 has been recently studied connection with cancer risk. The aim of present study was to investigate association between rs531564 risk clinicopathological characteristics colorectal (CRC). Two case-control studies involving 900 CRC patients 1110 cancer-free controls showed that significantly associated decreased Xuzhou population [GG vs. CC: OR...
Atrial electrical remodeling (AER) is the underlying mechanism of atrial fibrillation (AF). The present study investigated impact epicardial fat pad (FP) ablation on acute AER (AAER) and inducibility AF.AAER was performed in 28 mongrel dogs through 4-h rapid pacing (RAP). Before RAP, 14 (ablation group) underwent FP ablation, other (control a sham procedure. effective refractory period (ERP) vulnerability window (VW) AF were measured with without bilateral cervical vagosympathetic nerve...
Background A prolonged PR interval is a sign of increased risk cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with interval, QRS duration, QT and common arrhythmia disorders such as atrial fibrillation (AF) advanced atrioventricular block. However, other independent replication are required to validate result. This study assessed associations between ECG parameters, AF,...
MicroRNAs-associated single nucleotide polymorphisms are thought to play an important role in cancer development. We investigated the association of miR-146a rs2910164 polymorphism with risk colorectal (CRC) Chinese population.In this hospital-based case-control study 560 cases and 780 age- gender-matched healthy controls, was genotyped by polymerase chain reaction-restriction fragment length polymorphism.We found that not associated CRC risk. However, subgroup analysis gender showed...
Abstract The molecular mechanism of the occurrence and development papillary thyroid carcinoma (PTC) has been widely explored, but not completely elucidated. present study aimed to identify analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from Gene Expression Omnibus (GEO) database. differentially expressed (DEGs) between tissues matched non-cancerous identified using GEO2R tool. common DEGs in two screened out VennDiagram package,...
Anaplastic thyroid carcinoma (ATC) is a very rare malignancy; the pathogenesis of which still not fully understood. The aim present study was to identify hub genes and pathways in ATC by microarray expression profiling. Two independent datasets (GSE27155 GSE53072) were downloaded from GEO database. differentially expressed (DEGs) between tissues normal screened out limma package then enriched gene ontology (GO) KEGG pathway analysis. selected protein-protein interaction (PPI) A total 141...
Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, findings are inconsistent. The aim this study was to analyze between and through a case-control meta-analysis. In 430 colorectal (CRC) cases 445 healthy controls, genotyped by direct sequencing. STATA software used calculate pooled odds ratio 95% confidence interval in meta-analysis including 4,649 5,590 controls. Both showed that associated increased CRC. Individuals carrying AA or...
LncRNA prostate cancer-associated transcript 1 (PCAT1) is a well-known oncogene, but the mechanisms of exosomes PCAT1 in colorectal cancer (CRC) remain largely unknown. Thus, lncRNA were investigated. The expressions tissues from stage 0-I and II-III CRC patients, intestinal epithelial cell line FHC two lines, HT29 HCT8 measured by real-time quantitative PCR. effects on adhesion invasion lines investigated cell-matrix transwell assays. In addition, target (ZNF217) was validated using an RNA...
Although obesity is a well-known risk factor for hyperuricemia, it remains unclear whether obese subjects with metabolically healthy status have decreased the of hyperuricemia and sex modifies association (MHO) risk. We aimed to investigate sex-specific between MHO other phenotypes use Bayesian networks determine visualize interactions among its related factors. This study was conducted using data from China Health Nutrition Survey 2009. Hyperuricemia defined as serum uric acid ≥ 420 μmol/L...
The coronary slow flow phenomenon (CSFP) is common in angiography, however its impact on left atrial (LA) function still controversial. This study aims to evaluate the LA structure and of patients with CSFP using two-dimensional speckle tracking echocardiography (2D-STE). Consecutive scheduled for angiography from January 2016 September 2017 were enrolled this study. Patients' demographic data, clinical histories, laboratory angiographic findings collected recorded. Diagnostic criteria based...
Interleukin-27 (IL-27) is a new member of the IL-12 family which plays key role in antitumor immunity. The aim present study was to investigate association between potentially functional polymorphism (rs153109, -964A>G) at promoter IL-27 and risk breast cancer Chinese population. We determined genotypes 326 cases 460 healthy controls by using polymerase chain reaction-restriction fragment length analysis. Logistic regression used analyze -964A>G susceptibility. There no significant cancer....
Abstract Background Besides environment and living habits, such as a sedentary lifestyle, smoking drinking, genetic variation also plays an important role in the development of colorectal cancer (CRC). This study was aimed to investigate miR‑27a rs895819 polymorphism on CRC risk Chinese population. Methods In case‐control including 208 312 age‐ gender‐matched healthy control subjects, genotyped using TaqMan allelic discrimination assay. Furthermore, pooled analysis based eligible studies...