A5053034325- Infections and bacterial resistance
- MicroRNA in disease regulation
- Bacterial biofilms and quorum sensing
- Virus-based gene therapy research
- RNA Research and Splicing
- Plant Pathogenic Bacteria Studies
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Cancer Treatment and Pharmacology
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Luminescence Properties of Advanced Materials
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Pluripotent Stem Cells Research
First Affiliated Hospital of Bengbu Medical College
2014-2025
Huaqiao University
2013-2025
Nanjing Medical University
2025
Weatherford College
2024
Xuzhou Central Hospital
2024
Bengbu Medical College
2021
Tianjin University
2020
Weifang Medical University
2016-2017
Xinjiang Medical University
2015
Dongguan People’s Hospital
2014
In this paper, near-infrared emitting long-persistence luminescent Zn3Ga2Ge2O10:Cr3+ (ZGG) nanoparticles with diameters of 30-100 nm and bright luminescence were prepared by a sol-gel synthesis method. After the surface amination, further bioconjugated breast cancer-specific monoclonal antibody (anti-EpCAM) to form ZGG-EpCAM nanoprobes which can specifically target cancer cell lines (MCF7) in vitro. The results vitro images show that signals from cells treated are stronger than those...
Kallistatin, which protects organs and cells against inflammation, fibrosis oxidative stress, is mainly synthesized secreted in liver. However, its relationship to human liver disease remains unclear. The purpose of this study was explore the between serum kallistatin clinical evidence both cirrhosis hepatocellular carcinoma (HCC), determine if levels could be used as a diagnostic indicator hepatic health status, especially (LC). Our cohort consisted 115 patients with clinically proven (LF),...
Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS) play a "double-edged sword" role in bone tissue. Therefore, developing responsive biomaterials to maintain redox balance dynamically is crucial enhanced Herein, microenvironment-responsive coordination nanoparticles (C-Ca-SalB NPs) composed of...
While neoadjuvant therapy combined with surgery remains standard for locally advanced esophageal squamous cell carcinoma (ESCC), survival outcomes remain suboptimal. Refining multimodal regimens (including chemoradiotherapy, chemotherapy, and emerging immunotherapy) is critical to improving prognosis. This study sought evaluate the efficacy safety of immuno-chemotherapy in treatment ESCC, examine correlation between tumor regression grade (TRG) imaging evaluation. In total, 106 patients...
Elizabethkingia anophelis, originally discovered from Anopheles mosquito gut, is an emerging pathogen, especially in immunocompromised patients. We isolated two strains of E. anophelis separate patients with multiple organ dysfunction syndrome and lower respiratory tract infection. In this paper, we reviewed the status infection its antibiotics resistance reported cases.
TCF21 is known to function as a tumor suppressor and deregulated in several types of cancers; however, its role breast cancer remains poorly understood. The aim this study was examine the expression messenger RNA (mRNA) evaluate clinical significance biological progression. mRNA analyzed cell lines tissues by qRT-PCR. Overexpression approach used investigate functions line (MDA-MB-231). A notably lower level found tissues. Furthermore, low associated with large size positive lymph node...
Rationale: Comamonas kerstersii mainly causes intra-abdominal infections with favorable outcomes due to high antibiotic susceptibility. We report the first case of pneumonia caused by C Kerstersii , which promoted patient death, and a second urinary tract infection extensive drug resistance. Patient concerns: A 46-year-old male (Case 1) craniocerebral injury underwent emergency decompressive craniectomy, but his condition deteriorated further presented discontinuous fever, small moist rales...
Previous studies have revealed that traditional real-time quantitative PCR (qPCR) underestimates adeno-associated virus (AAV) titer. Because the inverted terminal repeat (ITR) exists in all AAV vectors, only remaining element from wild genome could form special configurations to interfere with qPCR titration. To solve this problem, a modified and universal method was tested established.In work, there great variation titration of ssAAV2-EGFP (Enhanced Green Fluorescence Protein) scAAV2-EGFP...
Objective: Non-small cell lung cancer (NSCLC) is the most common type of human cancer, with highly aggressive, lethal malignancy and microRNAs have already been proven to be associated NSCLC tumorigenesis. In this study, we sought determine expression, clinical value its role in tumor progression. Methods: Clinical tissues lines were collected. Real-time PCR was performed quantify miR-498 expression. addition, association expression clinicalpathological factors prognosis statistically...
Abstract MiR-124 functions as a tumor suppressor and plays an important role in tumorigenesis. A common polymorphism (rs531564, C>G) the pri-miR-124 has been recently studied connection with cancer risk. The aim of present study was to investigate association between rs531564 risk clinicopathological characteristics colorectal (CRC). Two case-control studies involving 900 CRC patients 1110 cancer-free controls showed that significantly associated decreased Xuzhou population [GG vs. CC: OR...
Abstract Elizabethkingia anophelis 12012‐2 PRCM was isolated from a patient with multiple organ dysfunction syndrome and lower respiratory tract infection in China. Minimum inhibitory concentration (MIC) analysis demonstrated that it resistant to 20 antibiotics including trimethoprim/sulfamethoxazole ciprofloxacin, which were effective for the elimination of other infections. To investigate multidrug resistance pathogenicity mechanisms, we analyzed genome features compared them species. The...
Several microRNAs (miRNAs) are known as regulatory molecules involved in gastric tumor metastasis. The expression of miR‑337‑3p was revealed to be downregulated metastatic cells. Overexpression cancer cells resulted the reduction their invasive abilities. To characterize functions miR‑337‑3p, expressed a lymph node‑derived cell line, SGC‑7901. reduced viability but had no effects on cycle. Wound healing and Transwell migration assays that inhibited capacity capable binding 3'‑untranslated...
Abstract Myroides odoratimimus is an important nosocomial pathogen. Management of M. infection difficult owing to the multidrug resistance and unknown pathogenesis mechanisms. Based on our previous genomic sequencing data PR63039 (isolated from a patient with urinary tract infection), in this study, we further performed comparative analysis for 10 selected strains. Our results showed that these genome contexts were very similar phylogenetically related. Various prophages identified four...
Abstract Background: Garsorasib (D-1553), a potent KRAS G12C inhibitor, has previously demonstrated promising anti-tumor activity in G12C-mutated non-small-cell lung cancer (NSCLC) phase 1 study. Here we present the efficacy and safety of garsorasib pivotal 2 Methods: In this open-label, multicenter, single-arm study, patients received 600 mg twice daily 21-day cycles. Eligible criteria included with locally advanced or metastatic NSCLC harboring mutation, who had disease progression after...
Transcription factor 21 (TCF21) functions as a tumor suppressor and is inactivated in several types of cancer. The purpose this study to investigate whether TCF21 genetic polymorphisms(rs2327429 T>C, rs2327430 rs2327433 A>G, rs12190287 C>G, rs7766238 G>A, rs4896011 T>A) are associated with the risk breast cancer Chinese women. Logistic regression analyses showed that polymorphism was significantly reduced Stratified based on pathological type indicated only infiltrative ductal carcinoma....
Background: Bacterial hepatic abscess is a common occurrence in developing countries, which mostly caused by Klebsiella pneumoniae and E. coli. Pannonibacter phragmitetus, Gram-negative alkalitolerant bacillus that exists the natural environment. Human infection this bacterium rare, with only four cases reported. Method: We presented one of these bacterial liver ploymicrobial involving P. phragmitetus Streptococcus oralis, being predominate isolate. Result Discussion: Our strain was...
BACKGROUND:This study aimed to compare the efficacy and safety of vinorelbine plus cisplatin (NP regimen) vs. gemcitabine (GP for treatment metastatic TNBC after failure with anthracyclines taxanes. MATERIAL AND METHODS:A total 48 patients that failed in taxanes were enrolled randomly grouped. Patients NP group (n=22) given 25 mg/m² on days 1 8 2–4 each 21-day cycle, while subjects GP (n=26) administered 1000 cycle. The response adverse events compared between 2 groups every cycles....