The direct cross-coupling of quinoline-N-oxides with olefin derivatives has been realized using palladium acetate as the catalyst in absence external ligand and oxidant to give corresponding 2-alkenylated quinolines 1-alkenylated isoquinolines chemo- regioselectively 27−95% yield. catalytic process is proposed proceed via C−H bond activation quinoline-N-oxide Pd(OAc)2 followed by Heck coupling olefin. resultant N-oxide alkenylated quinoline can oxidize reduced Pd(0) regenerate Pd(II) active...

An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C-H bond activation has been developed. Commercially available less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl quinolines obtained in up 91% yields chemo- regioselective manners.

A direct C–H bond phosphonation of quinoxalin-2(1<italic>H</italic>)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed.

A novel strategy of dehydrogenative Heck reaction controlled by redox process ferrocene has been developed. Commercially available chiral amino acid as ligand realized asymmetric reaction, leading to planar-chiral derivatives with excellent enantioselectivity and in good yields (up 99% ee 98% yield).

A highly efficient and concise one-pot strategy for the direct amination of quinoline N-oxides via copper-catalyzed dehydrogenative C–N coupling has been developed. The desired products were obtained in good to excellent yields 22 examples starting from parent aliphatic amines. This methodology provides a practical pathway 2-aminoquinolines features simple system, high efficiency, environmental friendliness, low reaction temperature, ligand, additives, base, external oxidant free conditions.

About specifics: A method for the regiospecific synthesis of title compounds through an unprecedented Michael addition/deacylative diazo transfer/cyclization sequence has been established. The simple and practical can be used modification primary amines including chiral α-amines. process involves formation three covalent bonds cleavage two (see scheme, Ts=4-toluenesulfonyl). As a service to our authors readers, this journal provides supporting information supplied by authors. Such materials...

Abstract An efficient and concise one‐pot strategy for the direct alkylation of quinoline N‐ oxides via palladium‐catalyzed dual CH bonds activation has been developed. This methodology provides quinoline‐containing heterocyclic molecules in moderate to excellent yields. magnified image

The first catalytic and enantioselective C-H direct acylation of ferrocene derivatives has been developed. A series 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient concise one-pot conditions up to 85% yield 98% ee. products obtained could be easily converted various chiral ligands via diverse transformations.

A novel, efficient and practical method for copper-catalysed oxidative C-3 amination of quinoxalin-2(1<italic>H</italic>)-ones with primary or secondary amines as the nitrogen sources has been developed.

N-Pyridylation of various N-heteroarenes, including N-heteroarene-containing peptides, was achieved using N-propargyl enaminones (isolated or generated in situ from propargyl amine and propynones) as masked polysubstituted pyridine cores. This metal-free procedure proceeds under mild reaction conditions generates 1 equiv H2O the sole byproduct.

The use of an 'internal' oxidant contained within a directing group has emerged as practical strategy in metal-catalyzed direct C–H activations recent years, owing to its being highly sustainable. This review presents the rapid advances this novel through analyzing and comparing different types internal transition-metal-catalyzed activation reactions. 1 Introduction 2 N–O Bond Internal Oxidant 2.1 O-Linked Moiety Leaving Group 2.1.1 <i>N</i>-Oxide 2.1.2 <i>N</i>-Acyloxy 2.1.3 Oxime 2.1.4 <i>...

Picolinamide has first been employed as a traceless directing group for the cobalt-catalyzed oxidative annulation of benzylamides with alkynes to synthesize isoquinolines through C–H/N–H bonds activation. Oxygen is used terminal oxidant. This protocol exhibits good functional tolerance and excellent regioselectivity. Both internal can be efficiently applied this catalytic system substrates.

A novel strategy to 4(3<italic>H</italic>)-quinazolinones from ketoalkynes and <italic>o</italic>-aminobenzamides through C–C triple bond fragmentation two C–N formations under external oxidant metal free conditions.

An efficient protocol for copper-catalyzed direct cross-coupling of aryl sulfonyl chlorides with <italic>H</italic>-phosphonates has been developed. The various <italic>S</italic>-aryl phosphorothioates were afforded in up to 86% yield 20 examples.

Pd(II)-catalyzed C-H sulfonylation of azobenzenes with arylsulfonyl chlorides has been developed. The sulfonylazobenzenes were obtained in moderate to excellent yields for 28 examples. This protocol features high efficiency, wide functional group tolerance, and atom economy.

Introducing aryl moieties into heterocyclic scaffolds is a key step in the syntheses of natural products, drugs, and functional materials.

This review summarizes the recent advances in synthetic application of iodonium ylides covering 2017 to 2022.

An efficient and direct 2-acetoxylation of quinoline N-oxides via copper(I) catalyzed C–H bond activation has been developed. This transformation was achieved using TBHP as an oxidant in the cross-dehydrogenative coupling (CDC) reaction with aldehydes, provided a practical pathway to 2-acyloxyl quinolines.

A redox-economic strategy has been developed, involved in an efficient Rh(III)-catalyzed oxidative C–H activation and alkyne annulation with perester as the oxidizing directing group. In this process, cleavage of O–O bond internal oxidant is described for first time. This reaction could be carried out under mild conditions exhibits excellent regioselectivity wide functional groups tolerance.

A direct C–H/P–H functionalization of heteroaryl <italic>N</italic>-oxides with H-phosphonates under metal and oxidant free conditions was developed. Various phosphonate derivatives were obtained in up to 92% yield a chemo- regioselective manner.

A highly efficient and practical procedure to acylazobenzene via Pd-catalyzed oxidative C–H bond activation from toluene has been developed. Various mono- diacylazobenzene were afforded simultaneously in moderate excellent yields for 33 examples. Toluene its derivatives served as potential ideal acylation reagents. The diacylated products could be controlled by the oxidant loading.

An efficient and regioselective alkenylation of azaheterocycle N-oxides with alkenes catalyzed by iodine under metal- external oxidant-free reaction conditions has been developed. A variety (E)-2-styrylazaheterocycles have produced in moderate to excellent yields. The mechanistic exploration indicated that the N-oxide group played dual roles as both directing an internal oxidant this catalytic cycle.